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Taxing Profit in a Global Economy
The international tax system is in dire need of reform. It allows multinational companies to shift profits to low tax jurisdictions and thus reduce their global effective tax rates. A major international project, launched in 2013, aimed to fix the system, but failed to seriously analyse the fundamental aims and rationales for the taxation of multinationals' profit, and in particular where profit should be taxed. As this project nears its completion, it is becomingincreasingly clear that the fundamental structural weaknesses in the system will remain. This book, produced by a group of economists and lawyers, adopts a different approach and starts from first principles in order to generate an ...
Immunology of Psoriatic Disease
Psoriasis is a chronically relapsing inflammatory skin disorder affecting about 2% of the worldwide population. The disease is associated with important systemic manifestations, including cardiovascular comorbidities and metabolic syndrome. In addition, about 30% of patients develop joint inflammation known as psoriatic arthritis (PsA). Our knowledge on the pathogenesis of psoriasis has dramatically expanded in the last decade, suggesting the existence (or co-existence) of both auto-immune and auto-inflammatory components. Skin lesions develop from a complex interplay between keratinocytes, vascular endothelium, dendritic cells, and T cells, generating a self-sustaining inflammatory cycle. W...
Lymphocyte Homing to the Skin
Over the last decade, enormous progress in the understanding of T-cell homing has made it possible to identify the multitude of molecules involved, such as cytokines, chemokines, and adhesion molecules, and to unravel their complex interactions resulting in controlled, non-random T-cell recirculation. These insights are now being explored therapeut
Moderate to Severe Psoriasis
Written by experts in the dermatology field, this new fourth edition of Moderate-to-Severe Psoriasis discusses the current use of biologics and other pharmacologic and phototherapy treatments for moderate-to-severe psoriasis. Illustrated with high quality color figures, this standalone text emphasizes safe and effective treatments for the psoriasis
Subversive Influences in Riots, Looting, and Burning: October 25,26, 31 and November 28, 1967 (including index)
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