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Head and Neck Cancer
This second edition provides a comprehensive view of consolidated and innovative concepts, in terms of both diagnosis and treatment. Written by leading international physicians and investigators, this book emphasizes the necessity of combining local and systemic treatments to achieve the objective of yielding higher cure rates and lower toxicities. Heavily updated from the previous edition, it highlights new surgery and radiotherapy techniques, disease awareness, patient quality of life, and comprehensive management. Head-and-neck cancers are a complex clinical entity and their response to treatment is also known to vary markedly in function of host-related factors. Notwithstanding the...
Cancer Immunotherapy Principles and Practice
“Drs. Butterfield, Kaufman and Marincola on behalf of the SITC have created a comprehensive must-have resource covering the basic and translational science behind approved and investigational immune therapies, and disease-by-disease clinical application of the therapies, written by leaders in the field. The textbook will be highly valuable reading for those just entering the field and for experienced scientists and clinicians looking to expand their knowledge base.” —Mario Sznol, MD, Professor of Medicine (Medical Oncology), Yale School of Medicine, New Haven, Connecticut “Given the important and exciting advances in cancer immunotherapy, it is not surprising that there is no dearth ...
Links Between Recombination and Replication
There has been a sea change in how we view genetic recombination. When germ cells are produced in higher organisms, genetic recombination assures the proper segregation of like chromosomes. In the course of that process, called meiosis, recombination not only assures segregation of one chromosome of each type to progeny germ cells, but also further shuffles the genetic deck, contributing to the unique inheritance of individuals. In a nutshell, that is the classical view of recombination. We have also known for many years that in bacteria recombination plays a role in horizontal gene transfer and in replication itself, the latter by establishing some of the replication forks that are the stru...
SITC’s Guide to Managing Immunotherapy Toxicity
The Society for Immunotherapy of Cancer's handbook,SITC’s Guide to Managing Immunotherapy Toxicity, is a practical reference to managing side effects associated with FDA-approved cancer immunotherapy drugs. Separated into two parts, Part I contains chapter-based overviews of immune checkpoint inhibitors in the clinic, starting with anti-CTLA4 agents, anti-PD1/PD-L1 agents, and approved immunotherapeutic combinations. These chapters cover relevant mechanisms of action, indications, and toxicities seen while combating early, advanced, and metastatic stages in cancer patients. Part II is structured by common and uncommon toxicities that affect major organ sites throughout the body. It begins ...
Melanoma
Melanoma is one of the most types of cancer. When melanoma is detected at an early stage, treatment is highly successful, but outcomes can be poor when the disease is advanced. There has been significant progress in our understanding of the molecular biology, genetics, and immunology of melanoma over the past decade. This has been accompanied by rapid advances in therapeutic strategies for patients with melanoma. This book provides the clinician and the researcher with a broad understanding of the molecular and cellular pathogenesis of melanoma, explores the clinical characteristics and criteria for clinical and pathological staging of the disease, and provides an overview of current and evolving treatment strategies in the adjuvant, metastatic, and preventive settings. The treatment of special populations and rare variants of melanoma that often present particular clinical challenges is also covered. Authored by international experts in melanoma biology and clinical management, this volume concisely explains how to diagnose, treat, and prevent melanoma while reviewing advances in basic science and providing an overview of innovative approaches still under development.
Advances in Molecular and Pharmacological Mechanisms of Novel Targeted Therapies for Melanoma
Malignant melanoma is the most aggressive type of skin cancer with invasive growth patterns. Recent advances in melanoma management have focused on cell growth, proliferation, migration, and survival biomarkers. Numerous FDA-approved molecular-targeted therapies, such as tyrosine kinase inhibitors (TKIs), have been developed targeting genetic biomarkers that play a critical role in tumorigenesis when overexpressed. The use of targeted therapies as an alternative or adjuvant to immunotherapy has revolutionized the management of metastatic melanoma. Although this treatment strategy is more efficacious and less toxic than traditional therapies, targeted therapies are less effective after prolonged treatment due to acquired resistance given the mutations and activation of resistant mechanisms in melanoma tumors. In this sense, identifying novel target therapies and repositioned drugs that could modulate the disease progression, the potential molecular and pharmacological mechanisms of therapies are of utmost interest.
Pocket Oncology
Pocket-sized and easy to use, Pocket Oncology, 3rd Edition, provides up-to-date information essential to caring for patients with cancer, from cancer biology, prevention, screening, treatment, and supportive care to new advances in all areas of the field for both adult and pediatric patients. Written and edited by leading cancer experts at Memorial Sloan Kettering Cancer Center, this unique, loose-leaf resource is designed for portability and quick reference, with information presented in a bulleted, outline format throughout.
Battling Melanoma
In June 2013, Gordon Cornwall’s melanoma went metastatic and spread to his brain. He and his wife, Claudia, thought it was “game-over.” But his oncologist encouraged them to look for a clinical trial that might work for his form of melanoma. After embarking on a continent-wide search, they found a study in Texas with spots for just two more patients. They scrambled to get Gordon enrolled, and in August 2013, three days after he had his first infusion, he was astonished to see a lump on his shoulder softening and shrinking. Three months later, in November, a CT-scan revealed that all his tumors had disappeared. This story of one couple’s battle to beat melanoma illustrates how a new t...
On The Other Side of TERMINAL
The doctor’s message was clear: “Your cancer is now terminal.” Echoing an enduring message of rare vulnerability and uplifting positivity, On the Other Side of TERMINAL is a powerful book that shares author Allen Chankowsky’s inspiring and deeply authentic account of his 30-year relationship with cancer. Shattering all expectations, Allen bravely exposes the depths in which he struggled to overcome his rare form of stage-4 cancer. With a palpable sense of unmistakeable urgency, his unique style skilfully illuminates the emotional strength it takes to manage the realities of living with a world-crushing diagnosis. First appearing as an interview in the best-selling book, I Survived Ca...
