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Knowledge Management in the Pharmaceutical Industry
The Pharmaceutical Industry has been undergoing a major transformation since the heady days of 'big pharma' in the 1970s and 80s. Patent expiry, the rise of generics, and the decline of the blockbuster drug have all changed the landscape over the last 10-15 years. It's an environment where products can take 10 years or more to come to market, billions are spent on research and development, jobs are being shed in the western pharma homelands and regulators and the public are more demanding than ever. So what part is Knowledge Management playing and going to play in this vital international industry? Knowledge Management (KM) has many facets from providing comprehensive knowledge bases for wor...
Tongue of Fire
Finalist for the 2016 Foreword INDIES Book of the Year Award in the Women's Studies category Winner of the 2017 Everett Lee Hunt Award presented by the Eastern Communication Association“br/> Silver Medalist, 2017 Independent Publisher Book Awards in the Women's Issues Category In this book, Donna M. Kowal examines the speeches and writings of the "Most Dangerous Woman in the World" within the context of shifting gender roles in early twentieth-century America. As the notorious leader of the American anarchist movement, Emma Goldman captured newspaper headlines across the country as she urged audiences to reject authority and aspire for individual autonomy. A public woman in a time when to be public and a woman was a paradox, Goldman spoke and wrote openly about distinctly private matters, including sexuality, free love, and birth control. Recognizing women's bodies as a site of struggle for autonomy, she created a discursive space for women to engage in the public sphere and act as sexual agents. In turn, her ideas contributed to the rise of a feminist consciousness that recognized the personal as political and rejected dualistic notions of gender and sex.
The Nile
This book provides an avenue for students to explore the Nile—the world's longest river—and better understand its larger role in society in the past, present, and future. The Nile River has been the most important natural resource for Egyptians and other Africans who live along its shores for thousands of years, bringing life to an otherwise arid and bleak desert region. Without the Nile, civilizations in Egypt could not have achieved such success. The physical, cultural, religious, and political impacts of this mighty riverway are enormous. This one-volume encyclopedia explores a breadth of topics related to the Nile River, from ancient irrigation techniques to 19th-century exploration ...
Late Graft Loss
In all varieties of organ transplants, early results have dramatically improved over the past two decades and failures due to acute rejection are becoming rarer. Efficient immunosuppressive regimens have been developed with the objective of very good results at 1, 3 and 5 years. Successful transplants, however, are significantly less frequent at 10 and 20 years, and many patients require retransplantation. Many factors are involved in late graft loss and it is now well recognized that, in addition to chronic rejection, a number of non-immunologic factors play a prominent role. In the case of renal transplantation, a reduced mass loss (transplantation of a single kidney, sometimes from an aged donor, ischemic injury and alteration of some nephrons in the case of early acute rejection) will result in slowly progressing chronic renal failure, even in the absence of any supplementary attack of an immunological nature. The new treatments must be analyzed in the light of their capacity to reduce these late failures. Several preventive measures can also limit both immunologic and non-immunologic factors of late transplant deterioration.
Practical Considerations for Adaptive Trial Design and Implementation
This edited volume is a definitive text on adaptive clinical trial designs from creation and customization to utilization. As this book covers the full spectrum of topics involved in the adaptive designs arena, it will serve as a valuable reference for researchers working in industry, government and academia. The target audience is anyone involved in the planning and execution of clinical trials, in particular, statisticians, clinicians, pharmacometricians, clinical operation specialists, drug supply managers, and infrastructure providers. In spite of the increased efficiency of adaptive trials in saving costs and time, ultimately getting drugs to patients sooner, their adoption in clinical ...
Autoimmune Disease Models
Because autoimmune disorders can wreak havoc in both humans and animals, these disorders are now the objects of intense and focused research. This book details specific animal models for a variety of autoimmune disorders. The contributors are recognized authorities who deal with the panoply of experimentally induced autoimmune disorders, including encephalomyelitis, allergic neuritis, uveoretinitis, myocarditis, and hepatitis. Also included are discussions of spontaneously appearing diseases such as autoimmune thyroiditis and systemic lupus erythematosus. Many other disorders are also covered in this comprehensive guide. Certain to be an aid in the planning of individual experiments and broader research programs, this book will be a valuable addition to the library of all practicing immunologists interested in immune system function and dysfunction.
Functional Neural Transplantation IV
Functional Neural Transplantation IV: Translation to Clinical Application, Volume 230 provides the current status of cell transplantation in the nervous system, with a focus on the conditions for achieving structural repair and functional recovery after brain damage or in neurodegenerative disease. New to this release are chapters that delve into the Mechanisms and Use of Neural Transplants for Brain Repair, Reprogramming of Somatic Cells: iPS and iN Cells, Brain Repair from Intrinsic Cell Sources: Turning Reactive Glia into Neurons, and Ex Vivo Gene Therapy for the Treatment of Neurological Disorders, Preparation, Characterization and Banking of Clinical-grade Cells for Neural Transplantati...
Cytokines and Cytokine Receptors
The field of cytokine research is expanding at a rapid pace Contributions from the major leading groups in the world on the structure and biological properties of cytokine and cytokine receptors, as well as integrated reviews on cytokines in various physiological and pathological conditions were presented in three issues of International Reviews of Immunology This collection of articles provided a unique source of information However, important discoveries are emerging very rapidly and some of the reviews written in 1997 are already outdated In this book, the editors assemble reviews that have been updated by their authors to include all the recent publications and unpublished data from the authors' laboratories This volume should serve as an excellent reference source for all those concerned by the multiple faces of cytokines in basic research and in the clinic
Novel Vaccination Strategies
The protection mode of most available vaccines is based on antibody responses. Since efficient immune responses to many pathogens rely on activating all arms of the immune system, traditional vaccine development does not provide efficient protection against many diseases. Novel vaccination strategies need to allow presentation of antigens that activate the full array of the immune response in the right composition and should prevent pathogen entry by mobilizing the mucosal immune response. New technological advances optimize the immunogenicity of 'live' and sub-unit vaccines. This book offers an interdisciplinary overview on research and future strategies for rational vaccine design based on recent developments in molecular biology and immunology. It covers new aspects of the immunological interplay between prokaryotic and eukaryotic systems as well as achievements in the development of novel vaccine candidates. Chapters on edible vaccines, on vaccines against bioterror agents and on economical and safety aspects of novel vaccine development round off this title.
Editors' Showcase: Obstetrics and Gynecology
We are pleased to present the first collection dedicated to highlighting the research of our Editorial Board, entitled Editors’ Showcase: Obstetrics and Gynecology. This exclusive collection is open to Editorial Board members only, and will feature high-quality contributions from our Associate and Review Editors. Specialty Chief Editor Professor Simcha Yagel leads this initiative, supported by Assistant Specialty Chief Editor Sarah Cohen, which will focus on new insights, novel developments, current challenges, latest discoveries, recent advances, and future perspectives in the field of Obstetrics and Gynecology. The work presented here celebrates the broad diversity of research performed across the section and aims to put a spotlight on all areas of interest to our Editors.
