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Microglia in Health and Disease: A Unique Immune Cell Population
Microglia are essential for the development and function of the adult brain. Their ontogeny, together with the absence of turnover from the periphery and the singular environment of the central nervous system (CNS), make microglia a unique cell population compared to other tissue-macrophages. The unique properties and functions of microglial cells, such as their role in synaptic pruning or the exceptional capacity to scan the brain parenchyma and rapidly react to its perturbations, have emerged in recent years. In the coming years, understanding how microglia acquire and maintain their unique profiles in order to fulfil distinct tasks in the healthy CNS and how these are altered in disease, ...
Non-neuronal cell heterogeneity in the nervous system during health and disease
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Transdisciplinarity and Translationality in High Dilution Research
While evidence for the biological effects of high dilutions (above Avogadro’s number) has been extensively documented since the 1980s, it seems to remain invisible to part of the global scientific community. This book provides investigators and other interested readers with direct access to the latest research, conducted between 2009 and 2019, by members of the Groupe International de Recherche sur l’Infinitésimal, the first international scientific society devoted to scientific studies of high dilutions. As shown here, the state of the art in high dilution research allows answering with a sound, evidence-based “no” to the question “Is homeopathy really that implausible?” Therefore this book is an essential contribution to the ongoing debate on complementary and alternative medicine, much-needed by practitioners, patients, and governments in the formulation of healthcare policies.
Multidisciplinary Approach to Neurofibromatosis Type 1
This volume offers an update of the clinical signs, diagnostic criteria (including molecular diagnosis) and targeted therapies for a particular type of genodermatosis, providing a handy and unique tool for early diagnosis. In recent years, our understanding of genodermatosis and neurocutaneous syndromes has increased, but although Type 1 Neurofibromatosis (NF1) is the most common neuroectodermal disorder and involves a large number of patients and medical disciplines, this syndrome remains underestimated, often misdiagnosed thus leading to inaccurate treatment. The literature on the molecular and pathogenetic aspects is ample, but current clinical approaches, classification, diagnostic crite...
The Immunological Synapse - Part B
The Immunological Synapse - Part B, Volume 178 in the Methods in Cell Biology series provides state-of-the-art methods for the study of the immunological synapse. This first volume covers various aspects on T cell and natural killer (NK) cell synapses, including imaging polarized granule release using TIRF microscopy, analysis of actin reorganization and centrosome polarization, redirected degranulation, live cell-imaging to quantify cytotoxic and chemotactic dynamics, quantification of interactions between APCs and T cells, assessment of membrane lipid state at the immunological synapse, proteomic analysis and imaging of NK-tumor cell interaction, evaluating natural killer cell effector fun...
A year in review: Discussions in cancer immunity and immunotherapy
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Reproducibility and Replicability in Parkinson's Disease and Age-Related Movement Disorders
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Consequences of the COVID-19 Pandemic on Care for Neurological Conditions
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Imaging of the Spine
Imaging of the Spine-an exhaustive, full-color reference-combines the ease of use of an atlas with the comprehensive coverage of a definitive reference work, in print and online. Renowned experts Drs. Thomas P. Naidich, Mauricio Castillo, Charles Raybaud, James G. Smirniotopoulos, Soonmee Cha, and Spyros Kollias cover every aspect of spine imaging, including the latest diagnostic modalities, interventional techniques, and image-guided procedures through over 1300 digital quality illustrations. Access the fully searchable text online at expertconsult.com, with downloadable images. View 1300 digital quality images of both radiographic images and cutting edge modalities-MR, multislice CT, ultrasonography, and nuclear medicine. Consult the expertise of a diverse group of experts from around the globe on the imaging of the spine. Tap into comprehensive coverage that includes diagnostic and therapeutic options, with an emphasis on cost-effective imaging. Find information quickly and easily thanks to consistent and tightly focused chapters, a full color design, and key points boxes.
