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Free Radicals in Brain Pathophysiology
This volume provides an authoritative, comprehensive view of the most current issues in brain pathophysiology and offers a critical evaluation of antioxidant-based therapeutic approaches to neurodegeneration, providing an up-to-date account of the role of antioxidants in the prevention and moderation of clinical symptoms. Examines free radicals in spinal cord damage, subarachnoid hemorrhage, reperfusion damage, and cytotoxicity! With over 2400 references, tables, drawings, photographs, and micrographs, Free Radicals in Brain Pathophysiology focuses on important biological signaling molecules such as superoxide anion and nitric oxide evaluates the action of low levels of oxygen- and nitrogen-...
International Perspectives on Self-Regulation and Health
An attractive feature of self-regulation therapies is that, instead of doing something to the patients, they teach them to do something for them selves. Furthermore, the fact that the patient is able to do something to cope with his or her health problem can produce a significant reduction in the stress that may have contributed to that problem and in the additional stress that it produces. While the idea that the mind can playa role in the health of the body and some therapeutic techniques based on this idea are not new, remarkable scientific advances have been made recently in the area of self-regulation and health. There has been an exciting and rapidly accel erating increase in our basic science knowledge of homeostasis, or, in other words, how the body regulates itself in order to maintain health. Technical and conceptual advances are increasing our knowledge of the details of such regulation at all levels-cells, tissues, organs, organ sys tems, and the body as a whole. We are learning how the competing demands of different elements at each of these levels are adjusted by the brain, which, with its neural and humoral mechanisms, is the supreme organ of integration of the body.
Hydrogen Peroxide Metabolism in Health and Disease
Much of the biology of oxidative stress and oxidative signalling centres on the generation and handling of hydrogen peroxide. The overall aim for this book would be to provide an insightful and useful forum to assist with the understanding of the relevance of hydrogen peroxide generation and how this is managed in human biology. The target audience would be those who currently have an interest in the generation of ROS, but who do not have expertise in chemistry, as well as those experts in the chemistry of oxidative stress, but without detailed understanding of the biologically relevant setting. We would aim to bridge the gap in understanding between chemistry and biology.
Nutrition and Epigenetics
Nutrition and Epigenetics presents new information on the action of diet and nutritional determinants in regulating the epigenetic control of gene expression in health and disease. Each chapter gives a unique perspective on a different nutritional or dietary component or group of components, and reveals novel mechanisms by which dietary factors mod
Metallothionein IV
The Proceedings of the Fourth International Metallothionein Meeting (MT-97) feature the latest research on metallothionein. The book covers a broad range of topics which provide important information for both basic and clinical investigators. The selected 94 articles in this book are written by the leading scientists in the field around the world. This is an increasingly important, multi-disciplinary area of study that has benefitted from recent advances in concepts and methodologies from other fields.
Dietary Modulation of Cell Signaling Pathways
A consequence of rapid progress in the science of nutrigenomics and nutrigenetics is the substantial accumulation of data covering nutrienal modulation of gene expression at the cellular and subcellular levels. Current research is increasingly focused on the role of nutrition and diet in modifying oxidative damage in the progression of disease. Die
Oxidative Stress and Age-Related Neurodegeneration
Oxidative Stress and Age-Related Neurodegeneration brings together researchers from a variety of fields to compare normal aging and disease-related neurodegeneration in terms of susceptibility to and effects of oxidative stress. They address how these effects can be attenuated, and examine whether antioxidants and natural micronutrients, such as those found in Gingko biloba, green tea, blueberries, and grape seed extract, can play a role. The book includes various ways research is getting to the core of neurodegenerative disease, including the use of proteomics, comparisons to related diseases, and examinations at the cellular and molecular levels.
Glutathione
This is the first serious attempt to synthesize all that became known of glutathione over the last three decades. The book contains an update of glutathione biosynthesis with special emphasis on its regulation in adaptive stress responses. Other chapters review glutathione transport systems and glutathione peroxidases and their differences in substrate specificities and localization. Further contributions center on the diversified roles of different glutathione-S-transferases and the roles of nitrosoglutathione and glutaredoxins - a subfamily of redoxins. The book closes with discussions of the analogous or homologous thiol metabolism in pathogens and the potential suitability of involved en...
