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In a broad sense Design Science is the grammar of a language of images rather than of words. Modern communication techniques enable us to transmit and reconstitute images without the need of knowing a specific verbal sequential language such as the Morse code or Hungarian. International traffic signs use international image symbols which are not specific to any particular verbal language. An image language differs from a verbal one in that the latter uses a linear string of symbols, whereas the former is multidimensional. Architectural renderings commonly show projections onto three mutually perpendicular planes, or consist of cross sections at differ ent altitudes representing a stack of floor plans. Such renderings make it difficult to imagine buildings containing ramps and other features which disguise the separation between floors; consequently, they limit the creativity of the architect. Analogously, we tend to analyze natural structures as if nature had used similar stacked renderings, rather than, for instance, a system of packed spheres, with the result that we fail to perceive the system of organization determining the form of such structures.
A study that goes beyond the debate over functional specialization to describe the ways that emotion and cognition interact and are integrated in the brain. The idea that a specific brain circuit constitutes the emotional brain (and its corollary, that cognition resides elsewhere) shaped thinking about emotion and the brain for many years. Recent behavioral, neuropsychological, neuroanatomy, and neuroimaging research, however, suggests that emotion interacts with cognition in the brain. In this book, Luiz Pessoa moves beyond the debate over functional specialization, describing the many ways that emotion and cognition interact and are integrated in the brain. The amygdala is often viewed as ...
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Carbonic anhydrases (CAs; EC 4.2.1.1) are metalloenzymes present in all kingdoms of life, as they equilibrate the reaction between three simple but essential chemical species: CO2, bicarbonate, and protons. Discovered more than 80 years ago, in 1933, these enzymes have been extensively investigated due to the biomedical application of their inhibitors, but also because they are an extraordinary example of convergent evolution, with seven genetically distinct CA families that evolved independently in Bacteria, Archaea, and Eukarya. CAs are also among the most efficient enzymes known in nature, due to the fact that the uncatalyzed hydration of CO2 is a very slow process and the physiological d...
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