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Signal Transduction: Pathways, Mechanisms and Diseases
Providing an overview of recent developments in the field of signal transduction, this volume emphasizes direct clinical significance. As such, topics like nuclear receptors, apoptosis, growth factors, cell cycles and cancer are examined.
Cell Cycle Control and Dysregulation Protocols
Cell Cycle Control and Dysregulation Protocols focuses on emerging methodologies for studying the cell cycle, kinases, and kinase inhibitors. It addresses the issue of gene expression in vivo and in vitro, the analysis of cyclin-dependent kinase inhibitors, protein degradation mediated by the proteosome, the analysis of the transformed cell phenotype, and innovative techniques to detect apoptosis. Because there are already many manuals and protocols available, along with commercial kits and reagents, a variety of the more common techniques have not been included in our book. The protocols described, based on rather sophisticated techniques for in vivo and in vitro studies, consist of molecular biology, biochemistry, and various types of immunoassays. Indeed, the authors have successfully accomplished an arduous task by presenting several topics in the simplest possible manner. We are confident that Cell Cycle Control and Dysregulation Protocols will facilitate and optimize the work of practical scientists involved in researching the cell cycle. We greatly acknowledge the extraordinary contribution of the authors in writing this book.
Lung Cancer
The Methods in Molecular Medicine series is intended as a resource for both novice and experienced investigators attempting to diversify their tech- logical base in research. Lung Cancer: Volume 1: Molecular Pathology Me- ods and Reviews presents an overview of the current status of assays employed to detect and characterize the multitude of pathologies that contribute to the development of this deadly disease. As with all volumes in the Methods in Molecular Medicine series, the reader should find that each methods-based chapter provides clear instructions for the performance of various protocols, supplemented by additional technical notes that provide valuable insight. These notes are desig...
Cancer Epigenetics
Cancer Epigenetics: Biomolecular Therapeutics in Human Cancer is the only resource to focus on biomolecular approaches to cancer therapy. Its presentation of the latest research in cancer biology reflects the interdisciplinary nature of the field and aims to facilitate collaboration between the basic, translational, and clinical sciences.
Molecular Pathology of Gynecologic Cancer
This book focuses on putting successful molecular strategies into practice for the treatment of gynecologic cancer. It approaches research into the pathology and treatment of gynecologic oncology from both clinical and experimental perspectives. New insights made possible by the introduction of advanced technologies into the field are presented. This new volume will be necessary reading for clinicians and experimental researchers alike.
The Culture and Politics of Regime Change in Italy, c.1494-c.1559
This volume offers the first comprehensive survey of regime change in Italy in the period c.1494–c.1559. Far from being a purely modern phenomenon, regime change was a common feature of life in Renaissance Italy – no more so than during the Italian Wars (1494–1559). During those turbulent years, governments rose and fell with dizzying regularity. Some changes of regime were peaceful; others were more violent. But whenever a new reggimento took power, old social tensions were laid bare and new challenges emerged – any of which could easily threaten its survival. This provoked a variety of responses, both from newly established regimes and from their opponents. Constitutional reforms w...
Saliva and Oral Microbiota: From Physiology to Diagnostic and Therapeutic Implications
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Cancer Immunotherapies: From Efficacy to Resistance Mechanisms
Dr. Koguchi receives funding from Tesaro, a GSK company, Bristol-Myers Squibb, and Shimadzu Corporation.. Dr. Vujanovic is a co-inventor of a methodology licensed to INmune Bio, Inc. where a selective inhibitor of soluble TNF can be used to prevent or treat malignancies. Dr. Hansen is the recipient of a private grant from Eurostars Eureka. The other Topic Editors declare no competing interests.
The Patron Saint of Ugly
Catholic lore, American tales, and Sicilian superstition blend in this “clever, funny, heartbreaking, and heartwarming” novel (Publishers Weekly). Born with unruly red hair, a sharp tongue, and wine-colored marks all over her body—marks that oddly mimick a map of the world and make her subject to endless ridicule—Garnet Ferrari would hardly consider herself blessed. So when an emissary from the Vatican shows up at her door, convinced that her seeming ability to cure the skin ailments of others qualifies her for sainthood, she’s not quite convinced—or pleased. Garnet sets off on a quest to better understand who she is and where she and her unusual gifts came from. Tracing a twisted path that leads from Sicily to West Virginia, poverty to riches, romance to loss, reality to mythology, Garnet uncovers a truth far more powerful than any dermatological miracle: that the things of which we are most ashamed often become our greatest strengths. “A cleareyed, touching fable of a girl learning the hard truths about herself and others.” —Kirkus Reviews
Encyclopedia of Cancer
This comprehensive encyclopedic reference provides rapid access to focused information on topics of cancer research for clinicians, research scientists and advanced students. Given the overwhelming success of the first edition, which appeared in 2001, and fast development in the different fields of cancer research, it has been decided to publish a second fully revised and expanded edition. With an A-Z format of over 7,000 entries, more than 1,000 contributing authors provide a complete reference to cancer. The merging of different basic and clinical scientific disciplines towards the common goal of fighting cancer makes such a comprehensive reference source all the more timely.
