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Durable left ventricular assist device (LVAD) technology is advancing at a rapid pace with increasing reliability of mechanical circulatory support for progressively longer periods. With more patients living longer on their LVAD as destination therapy or until eventual heart transplantation, concomitant valvular disease will have a greater impact on outcomes and patient quality of life. While some valvular lesions exist prior to LVAD implantation, others develop de novo from continuous flow mechanical support physiology. The presence of valvular disease in the setting of LVAD support is known to reduce effective cardiac output, increase left ventricular and atrial pressure, and increase right ventricular afterload. These hemodynamic changes can in turn contribute to right heart failure and negatively impact patient outcomes.
This is the most authoritative textbook ever dedicated to the art and science of surgical coronary revascularization, with 71 chapters, organized in 9 sections, and written by over 100 recognized world experts. It covers every aspect of the surgical management of coronary artery pathology and ischaemic heart disease.
Cardiologie et maladies vasculaires - OFFRE PREMIUM
Development and Implications of Antimicrobial Resistance One of the most ominous trends in the field of antimicrobial chemotherapy over the past decade has been the increasing pace of development of antimicrobial resistance among microbial pathogens. The hypothesis that man can discover a magic bullet to always cure a particular infection has proved false. Physicians are now seeing and treating patients for which there are few therapeutic alternatives, and in some cases, none at all. Until recently there was little concern that physicians might be losing the war in our ability to compete with the evolving resistance patterns of microbial pathogens. Now the general public is very aware of the...
In the seventeenth century, a vision arose which was to captivate the Western imagination for the next three hundred years: the vision of Cosmopolis, a society as rationally ordered as the Newtonian view of nature. While fueling extraordinary advances in all fields of human endeavor, this vision perpetuated a hidden yet persistent agenda: the delusion that human nature and society could be fitted into precise and manageable rational categories. Stephen Toulmin confronts that agenda—its illusions and its consequences for our present and future world. "By showing how different the last three centuries would have been if Montaigne, rather than Descartes, had been taken as a starting point, To...
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This text covers the basic principles of mitochondrial dynamics in cardiovascular medicine, with particular emphasis on their functional roles in physiology and disease. The book will include articles pertaining to mitochondrial fitness on a global basis, providing therefore an update on the progress made in several aspects in the field. Thus, it will assist scientists and clinicians alike in furthering basic and translational research. Organized in sections focusing on: basic science, mitochondrial dysfunction in cardiac disorders, in vascular disorders, in metabolic disorders, in kidney disease, therapeutic challenges and options, this essential volume fills imperative gaps in understanding and potentially treating several cardiovascular disorders.