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Cancer Biology
A thorough yet concise account of cancer biology, this book emphasizes the cellular and molecular mechanisms involved in the transformation of normal into malignant cells, the invasiveness of cancer cells into host tissues, and the metastatic spread of cancer cells in the host organism. It also defines the fundamental pathophysiological changes that occur in tumor tissue and in the host animal or patient. The approach throughout the book is to discuss the historical development of a field, citing the key experimental advances to the present day, and to evaluate the current evidence that best supports or rules out concepts of the molecular and cellular mechanisms regulating cancer cell behavi...
The Anticancer Drugs
This text offers an up-to-date review of the field of cancer chemotherapy, including some of the new approaches to biological treatments of cancer and potential targets for new drug design. A detailed description of the pharmacology, mechanisms of action, toxicity, resistance mechanisms, and clinical usefulness of each class of drugs is given. The authors emphasize concepts involved in determining the mechanism of action and development of resistance, the determinants of drug responsiveness to chemotherapeutic agents, and a rationale for their clinical use in various types of cancer. The text is organized in a way that makes it easy for the reader to conceptualize how drugs work and categorize them by their mechanism of action. It facilitates an understanding of the rationale for chemotherapy with respect to the biology of the cancer cell and to tumor growth kinetics. Drawing on the fields of authors draw on the fields of medicinal chemistry, pharmacology, biochemistry, cell biology, molecular biology, and clinical medicine, this timely book is extensively referenced and provides a historical background for the development of each class of drugs.
Biomedical Index to PHS-supported Research: Project number listing, investigator listing
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The Pharmacological Basis of Therapeutics
Drugs acting on the central nervous system; Local anesthetics; Drugs acting at synaptic and neuroeffector junctional sites; Autacoids; Cardiovascular drugs; Water, salts, and ions; Drugs affecting renal function and electrolyte metabolism; Drugs affecting uterine motility; Gases and vapors; Heavy metals and heavy-metal antagonists; Locally acting drugs; Chemotherapy of parasitic diseases; Chemotherapy of microbial diseases; Chemotherapy of neoplastic diseases; Drugs acting on the blood and the blood-forming organs; Hormones and hormone antagonists; The vitamins.
