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Metabolic Bone Disease, Volume I covers the approach to a variety of disorders of mineral metabolism. The book discusses bone metabolism and calcium regulation; kidney function in calcium and phosphate metabolism; as well as the role of alkaline phosphatase in metabolic bone disorders. The text also describes the diagnostic value of bone biopsies; the etiology, clinical aspects, therapy, and the main syndromes of vitamin D deficiency, rickets, and osteomalacia; and the pathogenesis and therapy of osteoporosis. The pathogenesis and treatment of nephrolothiasis are also encompassed. Orthopedic doctors, physicians, endocrinologists, and people involved in the research of metabolic bone diseases will find the book invaluable.
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The early endeavors of the Harris Orthopaedic Lab contributed significantly to widely diverse aspects such as the first human limb replantation, osteoporosis, the cause of osteoarthritis of the hip, and the environment of human articular cartilage. Subsequent years were focused on improving total hip replacement surgery, reducing its most common and devastating problems. These ranged from fatal pulmonary emboli thru poor implant design to solutions for arthritis from total developmental dislocation, and finally to unraveling the mysteries of and ultimately to the elimination of a strange and dreaded, world wide disease which destroyed the bone around total hip replacements in a million patients. Results: His works have contributed to extensive improvement in musculoskeletal disease including to the the reduction in nearly every major complication of total hip surgery by an order of magnitude.