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Haploidentical Transplantation
In this book, world-renowned experts in the field express well-reasoned opinions on a range of issues and controversies relating to haploidentical transplantation with the aim of providing practicing hematologists with clinically relevant and readily applicable information. Among the areas covered are graft manipulation and methods to control T-cell alloreactivity, the nature of the ideal graft and donor, haploidentical transplantation in pediatric and adult patients with malignant and nonmalignant diseases, immunologic reconstitution following transplantation, complications, and the prevention and treatment of relapse post transplantation. Attention is drawn to the implications of high-impact clinical trials whenever such trials are available. The readily intelligible text is complemented by numerous helpful tables, algorithms, and figures. The book will provide practical support for hematologists and transplant physicians as they attempt to provide optimal care in this exciting but increasingly complex medical specialty.
Progress and Challenges in Transfusion Medicine, Hemostasis, and Hemotherapy
Modern transfusion medicine is sophisticated hemotherapy. Cellular and humoral blood components can be relevant in virtually every disease, either as a primary determinant in pathophysiology or as a victim of collateral damage, e.g. during treatment with cytostatic drugs, or as crucial substrates in replacement and hemostasis-navigated hemotherapy. With its interdisciplinary approach modern hemotherapy is a paragon of translational research bridging the bench-to-bedside gap in biomedicine. The state-of-the-art contributions collected here aim to stimulate lively discussions ' not only among blood center professionals but also with blood and vascular biologists, hematologists, immunologists, anesthesiologists, intensive care specialists, surgeons, cardiologists, nephrologists, rheumatologists, and pulmonary and infectious disease specialists.
Bone Marrow Transplantation Across Major Genetic Barriers
The importance of bone marrow transplantation for patients who do not have a matched sibling donor cannot be overestimated. This subject has always been in the public domain, accentuated by dramatic appeals, from time to time, to search for matched volunteer donors in the public at large. Unfortunately, the availability of such donors is limited, due to the remarkable genetic diversity of humans. Thus, although registries of such volunteers now include more than eight million individuals, we still face the problem of finding a matched donor for about 30% of patients in need. To address this burning issue, extensive clinical and basic research is performed in leading institutes around the world.This book presents updated accounts of the different aspects of this research. The scope of the book is very wide, including strategies to overcome graft vs. host (GVH) disease and graft rejection, cell therapy to prevent leukemia relapse, and a range of modalities to improve immune reconstitution after transplantation. In addition, new approaches to induce immune tolerance towards organ transplants by means of hematopoietic stem cell transplantation are extensively reviewed.
George Yeo: Musings - Series Two
George Yeo: Musings Series One and Series Two available as a set hereGeorge Yeo: Musings (In 3 Volumes) available as a set hereOver sessions which lasted two to three hours each time, every week for half a year, George Yeo met and mused over a wide range of topics with writer Woon Tai Ho and research assistant Keith Yap. Speaking from notes, he began with himself and his hope for Singapore, and then spanned over a wide range of subjects — from the importance of human diversity and Singapore's reflection within itself of the world, to history, politics, economics, philosophy, taijigong and religion. He gives his views on India, China, ASEAN, Europe, the US and other parts of the world, and how Singapore's history and destiny are connected to all of them. The style is conversational and anecdotal.George Yeo: Musings is exactly that — musings. Some themes recur throughout the book which reflect his view of life. But there is no grand theory. He does not expect all of his reflections to be of interest to everyone, but he hopes that everyone will find something of interest.This is the second of a three-part series.
Tumor Metabolome Targeting and Drug Development
In this volume, the major metabolic alterations identified in cancer and tumor-associated cells are explored, including discussions of former and emerging approaches to drug development in targeting cancer cell metabolism. The metabolic network in cells promotes the generation of both energy and biomass needed for them to grow, divide and differentiate. However, the metabolism of malignant cells generally varies from that of normal cells. These differences provide a platform for the discovery of new approaches to targeting potential vulnerabilities in cancer cells for therapeutic options Some of the significant changes that occur involve ATP production and consumption that modulates the ATP to ADP ratio, hypoxia and the effects of reactive oxygen species on glycolysis, regulation of mitochondrial respiration, induction and suppression of autophagy, and the Warburg effect and “reverse” Warburg effect--these topics and more are discussed in this volume.
Clinical Bone Marrow and Blood Stem Cell Transplantation
Drs Richard Champlin, Jerome Ritz, Willem Fibbe, Per Ljungman, and Malcom K. Brenner join Kerry Atkinson as editors of this definitive reference on the clinical practice and underlying science of hematopoietic stem cell transplantation. This third edition text is significantly revised and updated with 124 chapters balancing scientific explanations with practical information on patient care for all aspects of autologous, syngeneic, and allogeneic transplantation. This edition includes 18 new chapters on significant topics such as plasticity of stem cells, embryonic stem cells, and nonmyeloablative conditioning regimens. Thoroughly referenced through 2003, the chapters are divided into 15 sections, including biological background and practical procedures, clinical results, transplant-related and organ-specific complications, laboratory aspects, and developing areas, with a final 'breaking news' chapter from this rapidly evolving field. Over 170 internationally-recognized experts contributed to this authoritative and practical text that is an essential resource for hematologists, oncologists, and transplant specialists.
George Yeo On Bonsai, Banyan And The Tao
Since his undergraduate days in Cambridge, George Yeo has spoken and written much in and out of government. Many remember the things which he said or wrote years ago. This book is a compilation of some of his best speeches and writings which were selected by Asad Latif and Lee Huay Leng in consultation with him.The book has a rather unusual title because there are many aspects to George Yeo which makes him difficult to classify. As a student leader, he was radical but conciliatory. In the Singapore Armed Forces, he was atypical, moving from the Army to the Air Force before becoming Director of Joint Operations and Planning. In politics, he is fondly remembered by artists, journalists, doctor...
CRISPR-/Cas9 Based Genome Editing for Treating Genetic Disorders and Diseases
The CRISPR-Cas9 genome-editing system is creating a revolution in the science world. In the laboratory, CRISPR-Cas9 can efficiently be used to target specific genes, correct mutations and regulate gene expression of a wide array of cells and organisms, including human cells. CRISPR-/Cas9 Based Genome Editing for Treating Genetic Disorders and Diseases is a unique reading material for college students, academicians, and other health professionals interested in learning about the broad range of applications of CRISPR/Cas9 genetic scissors. Some topics included in this book are: the role of the CRISPR/Cas9 system in neuroscience, gene therapy, epigenome editing, genome mapping, cancer, virus infection control strategies, regulatory challenges and bioethical considerations.
George Yeo: Selected Musings
Over sessions which lasted two to three hours each time, every week for half a year, George Yeo met and mused over a wide range of topics with writer Woon Tai Ho and research assistant Keith Yap. Speaking from notes, he began with himself and his hope for Singapore, and then spanned over a wide range of subjects — from the importance of human diversity and Singapore's reflection within itself of the world, to history, politics, economics, philosophy, taijigong and religion. He gives his views on India, China, ASEAN, Europe, the US and other parts of the world, and how Singapore's history and destiny are connected to all of them. The style is conversational and anecdotal.George Yeo: Musings is exactly that — musings. Some themes recur throughout the book which reflect his view of life. But there is no grand theory. He does not expect all of his reflections to be of interest to everyone, but he hopes that everyone will find something of interest.This special edition offers a selection of Musings from the three series.
Current Perspectives in Bioscience Research
Current Perspectives in Bioscience Research is more inclined towards interdisciplinary studies. Recent developments in the technologies have led to a better understanding of living systems and this has removed the demarcations between various disciplines of life sciences. A new trend in life science incorporates biological research involving a merger of diverse disciplines such as (Zoology: Entomology & Fisheries, comparative anatomy of vertebrates and toxicology), Botany etc. The book encompasses topics on A Review on the potential of marine microbes in bio-plastics production, Phytochemical analysis and antibacterial activity of Nyctanthes arbor-tristis Linn against UTI causing pathogenic ...
