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Male Germline Stem Cells: Developmental and Regenerative Potential
Scientists investigating germ cells have, over the past 15 years, originated discoveries and innovations that give us valuable insights into the mechanisms that regulate not just stem cell function, but human development in its widest sense. With contributions from some of the leading researchers in the field, Male Germline Stem Cells: Developmental and Regenerative Potential assesses the implications of these discoveries for understanding the fundamental biology of germline stem cells as well as their potential for human stem cell-based therapies. This monograph covers many of the fundamental issues now being explored by today’s generation of stem cell researchers, including the field’s potential for regenerative medicine. Ranging from an assessment of the pluripotency of primordial germ cells and their possible applications in treating testicular cancer, to the recovery of once-mordant fertilization-competent sperm, this volume has it all. It is a reference point for any scientist involved in related research as well as being a timely summation of what could prove to be a hugely exciting and very fruitful area of inquiry.
Guide to Techniques in Mouse Development, Part B
This volume comprehensively covers new technologies and methodologies that have appeared for the study of mouse development - Update of volume 225, Guide to Techniques in Mouse Development, edited by P.M. Wassarman and M.L. DePamphilis and published in 1993 - Comprehensively covers: - new techniques for the cryopreservation of gametes and embryos - production of transgenic and null (knockout) animals (use of ES cells) - generation of conditional/inducible mutant animals, use of gene-trap mutagenesis - analysis of allele-specific expression, use of new reporter constructs - humanizing of transgenic animals - transcript profiling of mouse development - imaging of mouse development - rederivation of animals and use of mouse genomics
Advances in Lithium-Ion Batteries
In the decade since the introduction of the first commercial lithium-ion battery research and development on virtually every aspect of the chemistry and engineering of these systems has proceeded at unprecedented levels. This book is a snapshot of the state-of-the-art and where the work is going in the near future. The book is intended not only for researchers, but also for engineers and users of lithium-ion batteries which are found in virtually every type of portable electronic product.
Spermatogonial Stem Cells
This volume explores the latest techniques used in the field of mammalian germ cell biology to study key experimental approaches and perspectives for critical analysis of spermatogonial subsets including the rare spermatogonial stem cells (SSCs) pool. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding common pitfalls. Cutting-edge and comprehensive, Spermatogonial Stem Cells: Methods and Protocols is a valuable resource for both new and experiences investigators looking to expand their knowledge in this developing field.
Neurosteroids
Thirty years ago, the group of Baulieu and colleagues discovered that certain steroid hormones were present in higher amounts in the brain than in the plasma, and also found that suppression of circulating steroids by adrenalectomy and castration did not affect the concentration of pregnenolone, dehydroepiandrosterone and their sulfate esters in the rat brain. These seminal observations led to the concept that the brain, in very much the same way as the adrenal cortex, testis, ovary and placenta, was capable of synthesizing steroids. These brain born steroids, called neurosteroids, have been found to exert a vast array of biological activities. A number of steroidogenic enzymes have now been identified in the central nervous system by immunohistochemistry and in situ hybridization, and the neuronal and hormonal mechanisms regulating the biosynthesis of neurosteroids have been partially elucidated. The aim of this Research Topic is to celebrate three decades of research on neurosteroids by gathering a bouquet of review papers and original articles from leading scientists in the flourishing field of neurosteroids.
Mathematical Foundation of Fuzzy Sets
Introduce yourself to the foundations of fuzzy logic with this easy-to-use guide Many fields studied are defined by imprecise information or high degrees of uncertainty. When this uncertainty derives from randomness, traditional probabilistic statistical methods are adequate to address it; more everyday forms of vagueness and imprecision, however, require the toolkit associated with 'fuzzy sets’ and ‘fuzzy logic’. Engineering and mathematical fields related to artificial intelligence, operations research and decision theory are now strongly driven by fuzzy set theory. Mathematical Foundation of Fuzzy Sets introduces readers to the theoretical background and practical techniques require...
Textbook of Polytrauma Management
This textbook is a fully updated and revised third edition of a highly successful practical guide to the care of the polytrauma patient. Broadening its readership to students, this new edition comprehensively describes the clinical course of multiple and severe injuries, from the accident scene to rehabilitation. It provides essential practical information on the care of patients both with blunt and penetrating trauma to multiple body regions, and discusses the management of truncal injuries (head, chest, abdomen) as well as fractures of the extremities, pelvis and spine. Further, the book highlights associated injuries that may alter decisions concerning patients with polytrauma. This new, revised edition takes full account of recent developments, including the increasing economic pressure on health care systems, prehospital treatment, changes in trauma systems and related education, and the improved survival of polytrauma patients. Also covering improved monitoring options along with issues in late patient outcomes and rehabilitation this work will greatly assist students, emergency personnel, trauma surgeons, orthopaedic traumatologists, and anesthesiologists.
