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Monoclonal Antibody Therapy of Human Cancer
  • Language: en
  • Pages: 171

Monoclonal Antibody Therapy of Human Cancer

KENNETH A. FOON and ALTON C. MORGAN, JR. Passive immunotherapy using heteroantisera for the treatment of cancer in animals and humans has been studied for over 50 years. Attempts have been made to treat animal tumors with sera from immunized syngeneic, allogeneic, or xenogeneic animals. A number of studies of passive immunotherapy using heterologous antisera in humans have also been performed. These studies have generally been attempted in patients with large tumor burdens, and as would be expected, results have been transient at best. A wide variety of solid tumors as well as leukemias and lym phomas have been treated with antisera raised in sheep, horses, rabbits, and goats. Problems such ...

Biochemistry and Molecular Genetics of Cancer Metastasis
  • Language: en
  • Pages: 339

Biochemistry and Molecular Genetics of Cancer Metastasis

The success rate for treatment of primary neoplasms has improved sig nificantly due to improved surgical, radiotherapy, and chemotherapy methods, and by supportive patient care. In contrast, the treatment of cancer metastases, the cause of most cancer deaths, has not been very successful. Approximately 50% or more of patients with primary malignant neoplasms already have established metastases. Consequently, the most important problem in cancer treatment is the destruction or prevention of metastases. Metastases research has obvious clinical importance. Yet it has only been recently that investigators have attempted to study the mechanisms in volved in this process. This is in part due to th...

Mechanisms of Cancer Metastasis
  • Language: en
  • Pages: 430

Mechanisms of Cancer Metastasis

The past twenty years have witnessed significant advances in the treatment of cancer by surgery and radiation therapy. Gains with cytotoxic chemotherapy have been much more modest. Of the approximately 900,000 newly diagnosed cases of cancer each year, 50010 result in death of the patient. The primary cause of these deaths is metastasis. Although the term metastasis was first coined by Recamier in 1829, only in the past ten years have there been intensive scientific investigations into the mechanisms by which tumor cells metastasize. What has emerged is a complex process of host-tumor cell interactions which has been termed the metastatic cascade. Due to the complexity of the metastatic proc...

Cancer Chemotherapy and Selective Drug Development
  • Language: en
  • Pages: 536

Cancer Chemotherapy and Selective Drug Development

Over the past 30 years many significant advances have been made in the management of a number of disseminated malignant diseases. The prognosis for diseases such as childhood leukaemia, choriocarcinoma and Hodgkin's disease has gradually been transformed as better anti tumour agents have become available and their clinical use has been refined. During the past 10 years the advent of new agents, particularly cisplatin, bleomycin and the podophyllotoxins, has allowed the cure of disseminated testicular tumours. This degree of success has not, however, been achieved in the case of a number of other common cancers. Ovarian carcinoma is tantalisingly chemo-sensitive and although there are long te...

Oral Oncology
  • Language: en
  • Pages: 299

Oral Oncology

A multidisciplinary approach to the problems related to the diagnosis, treat ment, and rehabilitation of patients with oral cancer and precancer is reflected in the various specialties of the authors who contributed to this book. Today, patients with tumors of the oral cavity are dealt with preferably by a team of specialists who have been properly trained in the field of oncology, who have learned to appreciate each other's knowledge and experience, and who are able to operate as an integrated team. This book is intended for use by every physician and dentist involved in the diagnosis and management of oral cancer. It is 'presented in such a way as to be useful for both the physician in tra...

Platinum and Other Metal Coordination Compounds in Cancer Chemotherapy
  • Language: en
  • Pages: 813

Platinum and Other Metal Coordination Compounds in Cancer Chemotherapy

Proceedings of the Fifth International Symposium, held in Abano Terme (Padova), italy, June 29-July 2, 1987

Cumulated Index Medicus
  • Language: en
  • Pages: 1556

Cumulated Index Medicus

  • Type: Book
  • -
  • Published: 1995
  • -
  • Publisher: Unknown

description not available right now.

Intra-Arterial and Intracavitary Cancer Chemotherapy
  • Language: en
  • Pages: 286

Intra-Arterial and Intracavitary Cancer Chemotherapy

Proceedings of the Conference on Intra-arterial and Intracavitary Chemotherapy, San Diego, California, February 24-25, 1984

Blue Carbon Mangrove Ecosystems
  • Language: en
  • Pages: 219

Blue Carbon Mangrove Ecosystems

description not available right now.

Jahrbuch Öffentliche Sicherheit - 2014/2015
  • Language: de
  • Pages: 762

Jahrbuch Öffentliche Sicherheit - 2014/2015

Sicherheit" hat Konjunktur und lässt sich inzwischen kaum noch überblicken. Dabei tritt zugleich ihre Komplexität immer deutlicher hervor: die klassischen Bereiche der inneren und äußeren Sicherheit gehen mit vielfältigen Wechselwirkungen ineinander über, neue Faktoren erodieren das tradierte Verständnis und Instrumentarium — und das nicht erst seit dem 11. September. Das JBÖS versucht, dieser "neuen Unübersichtlichkeit" einer "erweiterten Sicherheit" Herr zu werden: durch die Beschreibung der aktuellen sicherheitsrelevanten Entwicklungen, deren begrifflich-theoretische Durchdringung und kritische Reflexion sowie durch den interdisziplinären Blickwinkel von Politik- und Rechtswissenschaften, Soziologie, Geschichte und Philosophie.