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The Collected Sicilian Folk and Fairy Tales of Giuseppe Pitré
This is volume 2 of a two-volume set that collects 300 of the most entertaining and important folk and fairy tales of Giuseppe Pitré, a nineteenth century Sicilian folklorist whose significance ranks alongside the Brothers Grimm. In stark contrast to the more literary ambitions of the Grimms' tales, Pitré’s possess a charming, earthy quality that reflect the customs, beliefs, and superstitions of the common people more clearly than any other European folklore collection of the 19th century. Edited, translated, and with a critical introduction by world-renowned folk and fairy tale experts Jack Zipes and Joseph Russo, this is the first collection of Pitré’s tales available in English. Carmelo Letterer's illustrations throughout the volume are as lively and vivid as the stories themselves, illuminating the remarkable imagination captured in the tales.
Academy; a Weekly Review of Literature, Learning, Science and Art
The Poetical gazette; the official organ of the Poetry society and a review of poetical affairs, nos. 4-7 issued as supplements to the Academy, v. 79, Oct. 15, Nov. 5, Dec. 3 and 31, 1910
The Emerging Discipline of Quantitative Systems Pharmacology
In 2011, the National Institutes of Health (NIH), in collaboration with leaders from the pharmaceutical industry and the academic community, published a white paper describing the emerging discipline of Quantitative Systems Pharmacology (QSP), and recommended the establishment of NIH-supported interdisciplinary research and training programs for QSP. QSP is still in its infancy, but has tremendous potential to change the way we approach biomedical research. QSP is really the integration of two disciplines that have been increasingly useful in biomedical research; “Systems Biology” and “Quantitative Pharmacology”. Systems Biology is the field of biomedical research that seeks to under...
Model-informed decision making in the preclinical stages of pharmaceutical research and development
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Hungering for America
Millions of immigrants were drawn to American shores, not by the mythic streets paved with gold, but rather by its tables heaped with food. How they experienced the realities of America’s abundant food—its meat and white bread, its butter and cheese, fruits and vegetables, coffee and beer—reflected their earlier deprivations and shaped their ethnic practices in the new land. Hungering for America tells the stories of three distinctive groups and their unique culinary dramas. Italian immigrants transformed the food of their upper classes and of sacred days into a generic “Italian” food that inspired community pride and cohesion. Irish immigrants, in contrast, loath to mimic the food...
The Changing Faces of Glutathione, a Cellular Protagonist
Glutathione (GSH) has been described for a long time just as a defensive reagent against the action of toxic xenobiotics (drugs, pollutants, carcinogens), both directly and as a cofactor for GSH transferases. As a prototype antioxidant, it has been involved in cell protection from the noxious effect of excess oxidant stress, both directly and as a cofactor of glutathione peroxidases. In addition, it has long been known that GSH is capable of forming disulfide bonds with cysteine residues of proteins, and the relevance of this mechanism ("S-glutathionylation") in regulation of protein function has been well documented in a number of research fields. Rather paradoxically, it has also been high...
