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Protein Degradation with New Chemical Modalities
Targeting protein degradation using small molecules is one of the most exciting small-molecule therapeutic strategies in decades and a rapidly growing area of research. In particular, the development of proteolysis targeting chimera (PROTACs) as potential drugs capable of recruiting target proteins to the cellular quality control machinery for elimination has opened new avenues to address traditionally ‘difficult to target’ proteins. This book provides a comprehensive overview from the leading academic and industrial experts on recent developments, scope and limitations in this dynamically growing research area; an ideal reference work for researchers in drug discovery and chemical biology as well as advanced students.
Scientific Integrity and Ethics in the Geosciences
Science is built on trust. The assumption is that scientists will conduct their work with integrity, honesty, and a strict adherence to scientific protocols. Written by geoscientists for geoscientists, Scientific Integrity and Ethics in the Geosciences acquaints readers with the fundamental principles of scientific ethics and shows how they apply to everyday work in the classroom, laboratory, and field. Resources are provided throughout to help discuss and implement principles of scientific integrity and ethics. Volume highlights include: Examples of international and national codes and policies Exploration of the role of professional societies in scientific integrity and ethics References t...
Extending the Charismatic, Ideological, and Pragmatic Approach to Leadership
The past 15 years of leadership research have taught us a valuable lesson: There is more than one way to be a successful leader. The Charismatic, Ideological, and Pragmatic (CIP) approach to leadership showcases three unique yet equally viable pathways to leading and influencing others. This book reviews the history of the CIP model of leadership and summarizes the empirical findings supporting the framework. Emerging areas of leadership research on the CIP model are explored, including: followership, shared leadership, measurement, and gender. Contributions from a range of international academics provide readers with insight into the foundation of the CIP theory of leadership and into where...
The Routledge Handbook of Events and Sustainability
This book provides a comprehensive overview and systematic guide to the current state of knowledge on events and sustainability. Offering multidisciplinary insights from leading scholars, the book explores contemporary issues, challenges and trends. The book starts with an introduction by the editors, defining key concepts and issues, as well as a discussion of the sustainable event debates. Specifically commissioned and carefully selected individual contributions are divided into eight main sections which critically explore the key areas of events and sustainability, providing expert-led insights into timely and relevant topics such as social and cultural responsibility, economic sustainability, environmental sustainability, sustainable events and education, inclusivity, supply side and technology and sustainability. The book concludes with a discussion by the editors of the debates in event sustainability, with a view to identify emerging issues and future research agendas. This handbook will be of pivotal interest to scholars, students and policy-makers working in events, tourism and hospitality management.
