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Cystic Fibrosis
Cystic fibrosis, a genetic disorder in children and young adults, is a multisystemic disease that mainly affects the lungs. Advances and improvements in the diagnosis and management of this condition have led to increased overall and symptom-free survival in cystic fibrosis patients. This book examines recent advances in the field and presents an evidence-based approach to the management of cystic fibrosis.
List of Regular and Reserve Commissioned and Warrant Officers on Active Duty in Order of Precedence and Temporary Members of the Reserve
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Metric Spaces of Non-Positive Curvature
A description of the global properties of simply-connected spaces that are non-positively curved in the sense of A. D. Alexandrov, and the structure of groups which act on such spaces by isometries. The theory of these objects is developed in a manner accessible to anyone familiar with the rudiments of topology and group theory: non-trivial theorems are proved by concatenating elementary geometric arguments, and many examples are given. Part I provides an introduction to the geometry of geodesic spaces, while Part II develops the basic theory of spaces with upper curvature bounds. More specialized topics, such as complexes of groups, are covered in Part III.
Thoracic Surgery in Children and Adolescents
The diagnosis and treatment of both congenital and acquired thoracic pathologies in children and adolescents require a high degree of specialization. This book provides practical guidelines for thoracic surgeons who operate on patients from neonatal age to adolescence and for pediatric surgeons who are challenged to treat disorders such as cystic malformations of the lung, mediastinal tumors, or chest wall deformities. The chapters, written by internationally acclaimed authors, include expert commentaries with tips and tricks for the clinical practice. Plus: QR codes for access to videos of surgical procedures.
Advances and Technical Standards in Neurosurgery
This volume reviews standard treatments for spinal dural arteriovenous fistulas, examining the anatomy of arteries and veins of the sylvian fissure, as well as microsurgical advances and the development of modern therapeutic strategies in intracranial meningiomas. The advances section presents a strategy for minimizing hearing loss after stereotactic radiosurgery for vestibular schwannomas, as well as a description of the mode of action and biology of ALA, including its interaction with tumor cells and the limits of this method. A dedicated chapter addresses the essential question of the limits (and merits) of various tractography techniques and of their importance for non-specialists, who may be tempted to use them uncritically. A further chapter examines molecular markers, which have become standard in neuropathological reports on intracranial tumors, reviewing the prognostic and predictive value of these modern molecular markers in gliomas. Additional chapters round out the coverage, offering a comprehensive overview of standard and advanced techniques.
Tumor Microenvironment
This book addresses the biological processes relevant to the immune phenotypes of cancer and their significance for immune responsiveness, based on the premise that malignant cells manipulate their surroundings through an evolutionary process that is controlled by interactions with innate immune sensors as well as the adaptive recognition of self/non-self. Checkpoint inhibitor therapy is now an accepted new form of cancer treatment. Other immuno-oncology approaches, such as adoptive cell therapy and metabolic inhibitors, have also shown promising results for specific indications. Immune resistance is common, however, limiting the efficacy of immunotherapy in many common cancer types. The rea...
Breast Cancer Treatment
There are different types of treatment for breast cancer, including surgery, chemotherapy, radiotherapy, hormone therapy, immunotherapy, and targeted therapy. Deciding on the types of treatment depends on several factors, such as the stage and grade of cancer, biomarkers, and general health of patients. The seventh volume of the "Interdisciplinary Cancer Research" series, entitled "Breast Cancer Treatment: An Interdisciplinary Approach" publishes comprehensive reviews on different treatment opportunities on breast cancer. An update on treatment of triple-negative breast cancer and ductal carcinoma in situ is provided. Ablative breast cancer surgery, radiotherapy, and percutaneous breast canc...
Metal-Ligand Interactions
In September 2002, a NATO-ASI was held in Cetraro (CS), Italy on the theme of "Metal-Ligand Interactions in Molecular-, Nano-, Micro-, and Macro-systems in Complex Environments". This event has followed the previous ones held in the same place in 1991, 1994 and 1998. In the present and the previous schools a broad interdisciplinary cross-section of experimental and theoretical researchers, interested in a better understanding of metal-ligand interactions from different viewpoints, was linked together to exchange experience, to review the state-of-the-art, to indicate new techniques and methods, to explore new fields and perspectives. Particular emphasis was given to the problems related with...
New Insights into Glioblastoma
New Insights into Glioblastoma: Diagnosis, Therapeutics and Theranostics provides a compendium of recent diagnostic and therapeutic advances in GBM, encompassing a pipeline of compounds and (bio) nanotechnology strategies that have stood out with potential increased antitumoral activity and capability to cross the blood-brain barrier. Issues and challenges related to their translation into the clinical practice and their contribution to the increase in survival rates and well-being of patients are addressed. This is a valuable resource for graduate students, oncologists, cancer researchers and members of the biomedical field who need to learn more on recent developments on the management of ...
