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Biology of T Cells - Part B
Biology of T Cells - Part B, Volume 342, the latest release in the International Review of Cell and Molecular Biology series, offers an overview of the major molecular and cellular aspects of T-cell biology and their links to human pathophysiology. Chapters in this release include Metabolism of T lymphocytes in health and disease, T lymphocytes and autoimmunity, Cancer immunosurveillance by T cells, T lymphocytes as targets in viral disorders, Molecular mechanisms underlying pharmacological immunosuppression, T lymphocyte-based immunotherapeutics, In silico methods to analyze T cell biology, and Engineering Platforms for T Cell Modulation. - Contains individual chapters that focus on one specific facet of the development, phenotype, function, study or pathophysiological relevance of T lymphocytes - Presents the latest release in the International Review of Cell and Molecular Biology series
Molecular Nutrition: Carbohydrates
Molecular Nutrition: Carbohydrates presents the nutritional and molecular aspects of carbohydrates. As part of the Molecular Nutrition includes sections covering carbohydrate metabolism, carbohydrates in the diet, insulin resistance, dietary sugars, cardiometabolic risk, lipoproteins, low-carbohydrate diets, antioxidants, refined dietary sugars, fats, glucose transporters, glucose sensing, the role of phosphorylation, carbohydrate responsive binding protein, cyclic AMP, peroxisome proliferator-activated receptors, SIRT1, insulinotropic polypeptide (GIP) and GIP receptor (GIPR) genes rRNA and transcription, and more. In addition, the book addresses emerging fields of molecular biology and presents important discoveries relating to diet and nutritional health. - Summarizes molecular nutrition in health as related to carbohydrates - Addresses emerging fields of molecular biology and presents important discoveries relating to diet and nutritional health - Includes key facts, a mini dictionary of terms and summary points
Activity-Based Protein Profiling
This volume provides a collection of contemporary perspectives on using activity-based protein profiling (ABPP) for biological discoveries in protein science, microbiology, and immunology. A common theme throughout is the special utility of ABPP to interrogate protein function and small-molecule interactions on a global scale in native biological systems. Each chapter showcases distinct advantages of ABPP applied to diverse protein classes and biological systems. As such, the book offers readers valuable insights into the basic principles of ABPP technology and how to apply this approach to biological questions ranging from the study of post-translational modifications to targeting bacterial effectors in host-pathogen interactions.
Immune Metabolism in Health and Tumor
This book offers a broad overview of the concepts and research findings in immunometabolism. The immune system is made up of numerous different cell types, pathways, and components that must be able to respond rapidly to a pathogen or cancer, but must also remain quiescent in the absence of challenges. Immune cells rely on metabolic pathways to adapt to changing environments and stimuli. Additionally, these cells can be modified in function or fate by fluctuations in available nutrients. The chapters in this book describe ways in which immune cells utilize and are regulated by metabolic pathways. Topics include how immune-cell metabolism shapes immune homeostasis, and how dysregulation of th...
God Is a Heartless Recluse
The story of an atheists search for universal ethics, God Is a Heartless Recluse demonstrates that theists claim of God as their Heavenly Father is delusional. A god who allows terminal childhood diseases, mass murderers, cannibals, and genocides is at best a heartless recluse. In reality, God is a figment of megalomaniacal minds that dont have the courage to accept the facts: Humans evolved from earlier primates. God is a human invention: animism, panpsychism, pantheism, polytheism, monotheism. The universe is indifferent to humanity. Paradise is a fictional luxury resort. Humanity is an adolescent civilization with the potential to mature, spread across the Milky Way, then to other galaxies and other universesto live forever in this eternal multiverse.
Drug Design of Zinc-Enzyme Inhibitors
Brings together functional and structural informationrelevant to the design of drugs targeting zinc enzymes The second most abundant transition element in living organisms, zinc spans all areas of metabolism, with zinc-containing proteins offering both established and potential drug targets. Drug Design of Zinc-Enzyme Inhibitors brings together functional and structural information relevant to these zinc-containing targets. With up-to-date overviews of the latest developments field, this unique and comprehensive text enables readers to understand zinc enzymes and evaluate them in a drug design context. With contributions from the leaders of today's research, Drug Design of Zinc-Enzyme Inhibi...
Italy
Definitive cultural guide to monuments, museums and architectural and archological sites. Each book in the Heritage Guide series provides: dozens of full-color maps; color photographs and line drawings accompanying detailed and up-to-date text; travelers' information with selected addresses of museums, galleries, theaters, cultural institutions, stores for fine shopping, cafes and pastry shops; listings of accomodations and restaurants with quality ratings, price range, addresses and telephone and fax numbers. Special features in The Heritage Guide to Italy: detachable fold-out map of the entire country; 120 maps and plans of cities and historical sites; 80 driving tours with detailed maps; nearly 1000 desciptions of cities, towns, villages and landmarks.
