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Mitochondrial Signaling in Health and Disease
Mitochondria have traditionally been associated with metabolic functions; however recent research has uncovered a central role for these organelles in cell signaling, cell survival, and cell death. Mitochondrial dysfunction is a factor in a myriad of pathophysiological conditions, including age-related neurodegenerative disorders, cancer, metabolic
Biological Reactive Intermediates IV
The finding that chemicals can be metabolically activated to yield reactive chemical species capable of covalently binding to cellular macromolecules and the concept that these reactions could initiate toxicological and carcinogenic events stimulated a meeting by a small group of toxicologists at the University of Turku, in Finland, in 1975 (Jollow et al. , 1977). The growing interest in this field of research led to subsequent symposia at the University of Surrey, in England in 1980 (Snyder et al. , 1982), and the University of Maryland in the U. S. A. in 1985 (Kocsis et al. , 1986). The Fourth International Symposium on Biological Reactive Intermediates was hosted by the Center for Toxicol...
Biological Reactive Intermediates Vi
This volume presents a discussion of the biological effects produced following the metabolism of xenobiotic chemicals to chemically reactive metabolites, i.e., toxic and carcinogenic effects, which have been the basis of all five earlier volumes in this series. In particular, this volume devotes sections to structure-activity relationships, recent advances in the understanding of the chemistry of reactive metabolites, and the generation and activity of reactive oxygen species with special emphasis on nitric oxide. There are also segments on DNA damage by reactive metabolites and DNA repair, tissue specific responses to BRIs, and human health effects of BRIs. The papers that comprise this volume were submitted by world class scientists who were in attendance at The Symposium on Biological Reactive Intermediates VI at the Université René Descartes, July 16-20, 2000.
Free Radicals in Biology and Medicine
Free Radicals in Biology and Medicine has become a classic text in the field of free radical and antioxidant research. Now in its fifth edition, the book has been comprehensively rewritten and updated whilst maintaining the clarity of its predecessors. Two new chapters discuss 'in vivo' and 'dietary' antioxidants, the first emphasising the role of peroxiredoxins and integrated defence mechanisms which allow useful roles for ROS, and the second containing new information on the role of fruits, vegetables, and vitamins in health and disease. This new edition also contains expanded coverage of the mechanisms of oxidative damage to lipids, DNA, and proteins (and the repair of such damage), and t...
Stories of Success
This book is the latest volume in the highly successful series Comprehensive Biochemistry. It provides a historical and autobiographical perspective of the developments in the field through the contributions of leading individuals who reflect on their careers and their impact on biochemistry. Volume 45 is essential reading for everyone from graduate student to professor, placing in context major advances not only in biochemical terms but in relation to historical and social developments. Readers will be delighted by the lively style and the insight into the lives and careers of leading scientists of their time.* Contributors are distinguished scientists in the field * Unique series of personal recollections * Presents scientific research in a historical perspective
Cell/Tissue Injury and Cytoprotection/Organoprotection in the Gastrointestinal Tract
Up-to-date reviews on the mechanisms of gastrointestinal injury and protection In recent years, there have been significant advances both in understanding the mechanisms involved in gastrointestinal mucosal injury and protection, as well as in the development of successful strategies for prevention and treatment of gastrointestinal injury. Nevertheless, many people worldwide still suffer from gastrointestinal damage. This book contains contributions by an international panel of researchers in the form of up-to-date reviews on the mechanisms of gastrointestinal injury and protection. These are complemented by papers discussing how these new findings about cell/tissue injury and cytoprotection/organoprotection can be applied to the prevention and treatment of tissue damage in the gastrointestinal tract. Moreover, the publication includes a special chapter on Andre Robert, who has discovered the phenomenon of gastric cytoprotection. This publication will be of great interest for both basic and clinical researchers in gastroenterology and pharmacology, reviewing the advances made so far and pointing towards future developments.
Calcium and Cell Function
Molecular Biology: Calcium and Cell Function, Volume VI deals with several topics relating to calcium and cell function. This book consists of nine chapters. Chapter 1 describes the various peptides that recognize calmodulin in a calcium-dependent fashion. Chapter 2 updates the molecular and regulatory properties of calmodulin-dependent phosphodiesterase, while Chapter 3 reviews a calmodulin-dependent protein phosphatase. The studies on the biophysical characterization of calmodulin are summarized in Chapter 4. In Chapter 5, the studies on a calcium-dependent protease from human erythrocytes are presented. The problem of an uncontrolled level of calcium that often precipitates toxic conseque...
Recent Advances in the Biology of Alcoholism
This valuable book, written by eminent researchers, focuses on the exciting developments in the field of alcohol metabolism and alcohol-endocrine interactions. They contribute significantly to our understanding of the metabolism of ethanol and its effects on the body with comprehensive chapters on the heterogeneity of aldehyde dehydrogenase, alcohol-drug interactions, the pathogenesis of alcoholic liver disease, and more.
Lipid Peroxides in Biology and Medicine
Lipid Peroxides in Biology and Medicine emphasizes the importance of the control of lipid peroxides in the body for the prevention and treatment of degenerative diseases. This book discusses the production of free radicals in vivo from the action of xenobiotics, and comparative aspects of several model lipid peroxidation systems. The lipid peroxidation and membrane alterations in erythrocyte survival, and lipid peroxidations of cholesterol are also deliberated. This text likewise covers the mechanism of protection against membrane peroxidation, lipid peroxides as a cause of vascular diseases, and peroxide-mediated metabolic activation of carcinogens. Other topics include lipid peroxide in aging process and production of ethane and pentane during lipid peroxidation. This publication is valuable to biologists, medical practitioners, and clinicians researching on lipid peroxides.
