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COP: “Buddy, I think this is a whorehouse.” BUDDY CIANCI: “Now I know why they made you a detective.” Welcome to Providence, Rhode Island, where corruption is entertainment and Mayor Buddy Cianci presided over the longest-running lounge act in American politics. In The Prince of Providence, Pulitzer Prize–winning journalist Mike Stanton tells a classic story of wiseguys, feds, and politicians on a carousel of crime and redemption. Buddy Cianci was part urban visionary, part Tony Soprano—a flawed political genius in the mold of Huey Long and James Michael Curley. His lust for power cost him his marriage, his family, and close friendships. Yet he also revitalized the city of Provid...
Brain Repair, addresses all relevant issues underlying the mechanisms of brain damage, brain plasticity and post-traumatic reorganisation after CNS lesions. This book is divided the three major sections that follow; cellular and molecular basis of brain repair, plasticity and reorganisation of neural networks, and experimental therapy strategies. Brain Repair is written by high profile, international experts who describe in detail the newest results from basic research and highlight new model systems, techniques and therapy approaches. Based on a careful analysis of the cellular and molecular reaction patterns of the CNS to lesions, the contributions cover possibilities for endogenous reorganisation and repair as well as exciting new therapies emerging from basic research, some of which have already been introduced into the clinics. Thus, this book is unique in bridging the gap between basic and clinical research. It will be a valuable tool for all students, researchers and clinicians interested in understanding the brain's capacity to cope with lesions and interested in learning about emerging new therapy concepts.
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The adult brain is not as hard-wired as traditionally thought. By modifying their small- or large-scale morphology, neurons can make new synaptic connections or break existing ones (structural plasticity). Structural changes accompany memory formation and learning, and are induced by neurogenesis, neurodegeneration and brain injury such as stroke. Exploring the role of structural plasticity in the brain can be greatly assisted by mathematical and computational models, as they enable us to bridge the gap between system-level dynamics and lower level cellular and molecular processes. However, most traditional neural network models have fixed neuronal morphologies and a static connectivity patt...
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