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Signal Processing and Machine Learning for Biomedical Big Data
Within the healthcare domain, big data is defined as any ``high volume, high diversity biological, clinical, environmental, and lifestyle information collected from single individuals to large cohorts, in relation to their health and wellness status, at one or several time points.'' Such data is crucial because within it lies vast amounts of invaluable information that could potentially change a patient's life, opening doors to alternate therapies, drugs, and diagnostic tools. Signal Processing and Machine Learning for Biomedical Big Data thus discusses modalities; the numerous ways in which this data is captured via sensors; and various sample rates and dimensionalities. Capturing, analyzin...
Intracranial Pressure and Brain Monitoring XIV
Nearly 80 short papers originating from the 14th International Symposium on Intracranial Pressure and Brain Monitoring held in Tuebingen, Germany, in September 2010 present experimental as well as clinical research data related to the naming topics of the conference. The papers have undergone a peer-reviewing and are organized in the following sections: methods of brain monitoring and data analysis, methods of invasive and non-invasive ICP assessment, the role of autoregulation, the role of tissue oxygenation and near-infrared spectroscopy, hydrocephalus/IIH imaging and diagnosis, management and therapy of hydrocephalus, management and therapy of traumatic brain injury, management and therapy of subarachnoid and intracranial hemorrhage, experimental approaches to acute brain disease. The book gives a good overview on the latest research developments in the field of ICP and related brain monitoring and on management and therapy of relevant acute brain diseases.
Healthcare Finance
Why healthcare finance? -- From the laboratory to the patient -- Present value relations -- Evaluating business opportunities -- Valuing bonds -- Valuing stocks -- Portfolio management and the cost of capital -- Therapeutic development and clinical trials -- Decision trees and real options -- Monte Carlo simulation -- Healthcare analytics -- Biotech venture capital -- Securitizing biomedical assets -- Pricing, value, and ethics -- Epilogue : a case study pf royalty pharma.
A Parametric Framework for Modelling of Bioelectrical Signals
This book examines non-invasive, electrical-based methods for disease diagnosis and assessment of heart function. In particular, a formalized signal model is proposed since this offers several advantages over methods that rely on measured data alone. By using a formalized representation, the parameters of the signal model can be easily manipulated and/or modified, thus providing mechanisms that allow researchers to reproduce and control such signals. In addition, having such a formalized signal model makes it possible to develop computer tools that can be used for manipulating and understanding how signal changes result from various heart conditions, as well as for generating input signals f...
Mathematical Modeling and Validation in Physiology
This volume synthesizes theoretical and practical aspects of both the mathematical and life science viewpoints needed for modeling of the cardiovascular-respiratory system specifically and physiological systems generally. Theoretical points include model design, model complexity and validation in the light of available data, as well as control theory approaches to feedback delay and Kalman filter applications to parameter identification. State of the art approaches using parameter sensitivity are discussed for enhancing model identifiability through joint analysis of model structure and data. Practical examples illustrate model development at various levels of complexity based on given physiological information. The sensitivity-based approaches for examining model identifiability are illustrated by means of specific modeling examples. The themes presented address the current problem of patient-specific model adaptation in the clinical setting, where data is typically limited.
A History of Clinical Psychology
A second edition of this book which details significant further developments in clinical psychology in the intervening twenty years. Some of these are personality functioning, diagnostic techniques and formulation and professional development.
The Century of the Child
In this book, Richardson crosses disciplinary boundaries to examine mental hygiene issues of contemporary concern in both the United States and Canada. The work juxtaposes a social history of the child in the twentieth century to shifts in private and public power as influenced by the mental hygiene movements in both countries. The author shows how the historical record sheds light on current policy concerned with mentally, emotionally, and educationally handicapped children. As a sociology of mental illness, the book examines the relationship between mental hygiene as a form of knowledge and the social institutions that fostered the use of psychiatric perspectives concerning child and family life. Significant topics covered in this regard include the history of early childhood and parent education, the origins of child psychiatry in treating juvenile delinquency, and the evolution of contemporary concepts of normal development.
Advanced State Space Methods for Neural and Clinical Data
An authoritative and in-depth treatment of state space methods, with a range of applications in neural and clinical data.
Intracranial Pressure and Brain Monitoring XV
This volume showcases recent high-quality work relating to the pathophysiology, biophysics, monitoring, and treatment of traumatic brain injury and hydrocephalus that was presented at the 15th International Symposium on Intracranial Pressure and Brain Monitoring (ICP), held in Singapore in November 2013. The included papers derive from experts in neurointensive care, physiology, physics, engineering, and neurosurgery who have made important contributions in this translational area of research. All were selected from among oral and oral-poster presentations following a rigorous peer-review process involving the ICP Board members, and their focus ranges from the latest research findings and developments to clinical trials and experimental studies. This collection of papers from ICP 2013 continues the proud tradition of publishing key work from the ICP symposia and will be of interest for all who wish to stay abreast of recent advances in the field.
