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Mouse as a Model Organism
  • Language: en
  • Pages: 176

Mouse as a Model Organism

Cell culture based research is important for our understanding of biological processes at the cellular and molecular level. Using this approach, the previous decades have produced a wealth of mechanistic information in all areas of biomedical research. Such in vitro research, however, lacks the complexity of in vivo investigations, where many different cell types interact with each other in a normal, three-dimensional environment, with normal levels of cytokines and growth factors. Furthermore, complex human diseases, such as cancer, diabetes or chronic inflammation, can only be modeled in vivo. Due to its small size, its short reproduction time, and the possibility to introduce specific gen...

Lessing Yearbook / Jahrbuch XLVII, 2020
  • Language: en
  • Pages: 235

Lessing Yearbook / Jahrbuch XLVII, 2020

Das Lessing Yearbook/Jahrbuch 2020 enthält Beiträge zu Lessings Aristoteles-Lektüre, zum Drama "Philotas" im Kontext des Siebenjährigen Krieges, zum Spiel-Begriff und zur Toleranz-Thematik in "Nathan der Weise", zu Lessings nachgelassenen Blättern zu "Nathan" und zur Rezeption von Lessings Dramen in Amsterdam. Außerdem enthält der Band Aufsätze zur Gefühlsthematik in Joachim Wilhelm von Brawes Drama "Der Freygeist", zur Rolle des Apostels Thomas in Klopstocks "Messias" und zur kognitiven Narratologie in Karl Philipp Moritz "Reisen eines Deutschen in England". Abschließend bietet der Band einen Tagungsbericht zur digitalen Erarbeitung der Texte Lessings.

Encyclopedia of Molecular Mechanisms of Disease
  • Language: en
  • Pages: 2348

Encyclopedia of Molecular Mechanisms of Disease

This comprehensive encyclopedia supplies the reader with concise information on the molecular pathophysiology of disease. Entries include defined diseases (such as Parkinson's disease) as well as pathophysiological entities (such as tremor). The 1,200 essays are brilliantly structured to allow rapid retrieval of the desired information. For more detailed reading, each entry is followed by up to five references. Individual entries are written by leading experts in the respective area of research to ensure state-of-the-art descriptions of the mechanisms involved. It is an invaluable companion for clinicians and scientists in all medical disciplines.

Nanotechnology and the Brain
  • Language: en
  • Pages: 336

Nanotechnology and the Brain

Nanotechnology and the Brain, the latest edition in the International Review of Neurobiology series is well-known for its appeal to neuroscientists, clinicians, psychologists, physiologists, and pharmacologists. Written by an internationally renowned expert in the field, this volume focuses on the application of nanotechnology in the brain, covering blood brain barrier biology and how nanoparticles should be engineered to tackle this barrier. - Covers a wide range of nanoparticles in dedicated chapters - Focuses on the application of nanotechnology in the brain, shedding light on blood brain barrier biology and nanoparticles engineering - Contains the diverse expertise of renowned contributors

Neurobiology of Acupuncture
  • Language: en
  • Pages: 363

Neurobiology of Acupuncture

This book summarises the recent development in acupuncture research and in particular, the neurobiology of acupuncture. It provides a focus but a diverse range of subjects covering many body systems. The first a few chapters discuss the basic principles of acupuncture, then its modulatory effects on nervous system such as induction of neurotrophin and neurogenesis in the brain. Late chapters explore the clinical effects and potential mechanisms of acupuncture on different conditions ranging from neurological diseases such as Parkinson's, Alzheimer's, and stroke, to psychiatric illnesses, insomnia, hypertension, gastrointestinal diseases and drug addiction. We believe this will promote the understanding acupuncture treatment and enhance acupuncture research in the future. - This volume of International Review of Neurobiology brings together cutting-edge research on the neurobiology of acupuncture - It reviews current knowledge and understanding, provides a starting point for researchers and practitioners entering the field, and builds a platform for further research and discovery

Neuroacanthocytosis Syndromes
  • Language: en
  • Pages: 285

Neuroacanthocytosis Syndromes

Neuroacanthocytosis Syndromes is the first comprehensive review of a field that has not yet received the attention it deserves. Affecting the brain as well as the circulating red cells, these multi-system disorders in the past had often been mistaken for Huntington's disease. Recent breakthroughs have now identified the molecular basis of several of these. This volume grew out of the first international scientific meeting ever devoted to neuroacanthocytosis and provides in-depth information about the state of the art. Its thirty chapters were written by the leading authorities in the field to cover the clinical as well as the basic science perspective, including not only molecular genetics but also experimental pharmacology and cell membrane biology, among others. The book vehemently poses the question of how the membrane deformation of circulating red blood cells relates to degeneration of nerve cells in the brain, the basal ganglia, in particular. It provides a wealth of data that will help to solve an intriguing puzzle and ease the suffering of those affected by one of the neuroacanthocytosis syndromes.

Neurological Disorders
  • Language: en
  • Pages: 1606

Neurological Disorders

This single-volume reference covers the natural course, treatment, and management of all neurological diseases affecting the brain, spinal cord nerves and muscles. This comprehensive text reference seeks to assist physicians with treatment by providing an easy-to-use compendium covering the treatment and management of all neurological diseases along with details on the natural course of these diseases. Organized for ease of use and quick reference, each chapter presents a neurological disorder or key symptoms and systematically discusses the clinical syndrome and differential diagnosis, natural course, principles of therapy, and practical management of each. Covers wide range of neurological conditions and potential treatments, including the evidence for and against each treatment Describes the spontaneous course of neurological diseases along with discussion of the management of different stages and variants of a disorder Presents special situations and exceptional cases in which alternative therapies should be considered

Hereditary Optic Neuropathies: A New Perspective
  • Language: en
  • Pages: 118

Hereditary Optic Neuropathies: A New Perspective

Topic Editor Valerio Carelli received financial support from Stealth BioTherapeutics. The other Topic Editors declare no competing interests with regard to the Research Topic subject.

Genetics Meets Metabolomics
  • Language: en
  • Pages: 328

Genetics Meets Metabolomics

This book is written by leading researchers in the fields about the intersection of genetics and metabolomics which can lead to more comprehensive studies of inborn variation of metabolism.

Multimodal and Longitudinal Bioimaging Methods for Characterizing the Progressive Course of Dementia
  • Language: en
  • Pages: 168