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Fishing's Greatest Misadventures
Fishings Greatest Misadventures presents 25 larger-than-life true stories covering the spectrum of fish tales, from terrifying to comical to downright bizarre. Everyday fishermen, journalists, and pros tell their stories of freak accidents, fish attacks, sabotage, pranks, getting lost at sea, idiotic decisions, eerie incidents, and other jaw-dropping calamities. This book takes you from the freshwater to the sea with stories about every form of angling, from fly-casting for trout to noodling for catfish, and big game sport fishing to casting for the unknown.
Translational Stroke Research
This volume sets a basis for effective translational research. Authored by experts in the field of translational stroke research, each chapter specifically addresses one or more components of preclinical stroke research. The emphasis is placed on target identification and drug development using state-of-the-art in vitro and in vivo assays, in combination with in vitro toxicology assays, AMDE and clinical design.
Drug Discovery and Evaluation: Pharmacological Assays
Now expanded and updated to include molecular biology and genetic engineering techniques. The second edition of this successful reference book contains a comprehensive selection of the most frequently used assays for reliably detecting the pharmacological effects of potential drugs. Each of the more than 1000 assays comprises a detailed protocol outlining the purpose and rationale of the method, a critical assessment of the results and their pharmacological and clinical relevance. The enclosed and fully searchable CD ROM allows easy identification of specific tests. An appendix with up-to-date guidelines and legal regulations for animal experiments in various countries will help the reader to plan experiments more effectively.
Peptide Receptors
Peptide Receptors Part I was published in 2000 (as volume 16 of the Handbook of Chemical Neuroanatomy series). This volume summarized current knowledge on the discrete anatomical distribution of ten families of neuropeptide receptors expressed in the mammalian CNS. Part II is its natural complement with chapters covering six additional families of neuropeptide receptors for ligands ranging from well known peptides such as the opioids and neurotensin to recently isolated ones like the orexins. As in the case of Part I, this volume integrates photomontages and maps of quantitative receptor autoradiography, in situ hybridization histochemistry and immunocytochemistry. Data derived from transgenic and knock-out animals are also summarized, helping to decipher the possible physiological and Pathophysiological role(s) of a given peptide family. Some chapters also review current knowledge on the profile of internalization of the neuropeptide-receptor complex, an area of intense research activities that should help to better understand mechanisms involved in desensitization and tachyphylaxis.
Drug Discovery and Evaluation: Pharmacological Assays
The new edition of this successful reference offers both cutting-edge and classic pharmacological methods. Thoroughly revised and expanded to two volumes, it offers an updated selection of the most frequently used assays for reliably detecting the pharmacological effects of potential drugs. Every chapter has been updated, and numerous assays have been added. Each of the more than 1,000 assays comprises a detailed protocol outlining purpose and rationale, and a critical assessment of the results and their pharmacological and clinical relevance.
Sidewalk Dance
From the author of Glass Bottle Season comes a gritty new coming-of-age novel that examines what happens when one man’s desperate journey to become a New York Writer leaves him more “tortured” than “artist.” Sidewalk Dance is a portrait of the artist as a deluded self-saboteur. Haunted by his brother’s tragic death in the War in Afghanistan and unable to process this trauma, Fisher shuns his elitist pedigree by abruptly quitting Yale Law School, changing his name to Fish, and moving to New York City. Once there, he sets about reinventing himself as a doomed playwright. Unfortunately for Fish, he is more of an idealist than a talent; a dreamer more than a doer. His delusions of gr...
