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Tumor microenvironment (TME) plays an important role in immunosuppressive mechanisms that result in immune editing and treatment resistance. Elucidating the diversity of stromal and immune cell distribution, polarization, and changes in their gene expression signatures will enable a better understanding of key events to improve treatment and prognosis. With the onset of immune checkpoint inhibitors (ICIs) in clinics for patients with solid tumors and hematologic malignancies, immunotherapy has taken a new direction in cancer management, especially as combination therapies. However, limitations encountered with the use of ICIs, including toxicity and immune-related adverse events (irAE) indic...
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We acknowledge the initiation and support of this Research Topic by the International Union of Immunological Societies (IUIS). We hereby state publicly that the IUIS has had no editorial input in articles included in this Research Topic, thus ensuring that all aspects of this Research Topic are evaluated objectively, unbiased by any specific policy or opinion of the IUIS.
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This book primarily fulfils the content needs of first-year B.Sc. nursing students but also helps the nurses in profession to hone their microbiology knowledge. Containing all the vital aspects of infection control practices and the details of various microorganisms suggested by the WHO, it serves as the best content resource for the nurses who need information on infection control. - Entire microbiology syllabus of the Indian Nursing Council covered. - All microbiology information needed for the undergraduate nursing students put in a systematic manner. - Concepts explained in lucid language for easy understanding by nursing students. - Content presented as bulleted lists for quick grasp of the subject matter. - Appropriate WHO guidelines and recommendations on infection control included. - Multicolour photographs, illustrations are used to explain complex microbiology concepts.
The Apc protein is a multifunctional participant in a diverse array of cellular functions. This book provides an overview of the functions performed by the Apc protein.
This text covers all aspects of the immunology of fungal infection. Beyond the basics, coverage includes recent developments in innate and adaptive immunological mechanisms involved in the host response to fungal infection. The volume’s topical sections provide an immunological perspective on the cells, soluble factors and receptors involved in recognising and combating fungal infections. Discussion includes descriptions of immunity to specific pathogens, immune-escape mechanisms used by fungi, and therapeutic strategies.
Gut Microbiome and Behavior, the latest volume in the International Review of Neurobiology series, provides a comprehensive overview of the gut microbiome on the brain and behavior, fully encapsulating the latest research in the field and defining the scope of this influence to outline potential mechanisms and possible implications. - Contains the expertise of contributors in the field who discuss the gut microbiome and its effect on the brain and behavior - Defines the scope of the influence of the gut microbiome and the potential mechanisms and implications - Charts the way forward in this frontier area of research