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Sesquiterpene Lactones
This book addresses chemical and biological aspects related to sesquiterpene lactones (STLs). Experts in different fields have been invited to contribute on this class of compound's chemistry, isolation and identification, biological activities (antibacterial, antifungal, antiviral, antitrypanosomal, antileishmanial,antiplasmodial, antiproliferative and antiinflammatory), synthesis, biosynthesis, derivatization and QSAR analysis. Taxonomic and chemotaxonomic aspects related to the Asteraceae family are also contributed. The book begins by describing the chemical characteristics of STLs, their classification in different skeleton types, synthesis, distribution in nature and their most importa...
WHO Global Report on Traditional and Complementary Medicine 2019
This report is structured in five parts: national framework for traditional and complementary medicine (T&CM); product regulation; practices and practitioners; the challenges faced by countries; and finally the country profiles. Apart from the section on practices and practitioners the report is consistent with the format of the report of the first global survey in order to provide a useful comparison. The section on practices and practitioners which covers providers education and health insurance is a new section incorporated to reflect the emerging trends in T&CM and to gather new information regarding these topics at a national level. All new information received has been incorporated into individual country profiles and data graphs. The report captures the three phases of progress made by Member States; that is before and after the first WHO Traditional Medicine Strategy (1999?2005) from the first global survey to the second global survey (2005?2012) and from the second survey to the most recent timeline (2012?2018).
Discovery and Development of Therapeutics from Natural Products Against Neglected Tropical Diseases
Discovery and Development of Therapeutics from Natural Products against Neglected Tropical Diseases draws together research on medicinal agents from natural sources as starting points for the design of drugs against Neglected Tropical Diseases (NTDs). From the prediction of promising leads and identification of active agents, to the extraction of complex molecules, the book explores novel, economical and efficacious therapeutics for these diseases. It describes current research and the role of natural products, antimalarial compounds from marine natural products and sesquiterpene lactones, natural antileprotic agents, natural products with potential against Leishmaniasis, Trypanosomiasis and...
Food Biotechnology
This resource examines trends in modern biotechnology, covering all aspects of this interdisciplinary field.
Evidence-Based Cardiology
This second editionis a ground-breaking clinical text with a strong emphasis on rigorous evidence. Leaders in the field discuss best practice in the light of systematic reviews and randomised control trials, and how best to treat where the information is less clear. Case histories provide intriguing discussions on how to apply the evidence in real life situations. Evidence-based Cardiology also includes free access to the latest evidence, which is automatically posted on a companion website.
Helicobacter pylori in Human Diseases
This book gathers a wealth of contributions on the virulence factors and pathogenic mechanism of Helicobacter pylori, prepared by leading international experts. In addition, it explores the epidemiology, diagnosis, treatment with drugs and probiotics, and prophylaxis by vaccination, reflecting the latest advances. H. pylori is a Gram negative microaerophilic bacterium that can produce various gastric diseases including gastritis, gastroduodenal ulceration, gastric cancer and gastric MALT lymphoma. Although efforts to combat H. pylori using a combination of proton pump inhibitor and several antimicrobial drugs have significantly decreased the burden of these gastric diseases, the microbial epidemiology and gastric pathogenesis following H. pylori infection are still not fully understood. Given its scope, the book offers a valuable resource not only for basic microbiologists, but also for researchers in the fields of pathology, biochemistry and genomics, as well as medical students/scientists.
The Intertextual Knot
This book is a thorough analysis of Alfred Hitchcock's Rope (1948) and of its multiple connections with the Leopold and Loeb murder case and the adaptation of Patrick Hamilton’s eponymous play. As an all-encompassing portrait of the movie, the book discusses its aesthetics, style, role within cinema history, challenges in production, innovations introduced and of course Hitchcock’s signature features. However, as the analysis unfolds, the film reveals itself as an actual journey through the nightmares and the hopes that characterized the 20th century. Nazism and anti-Nazism, antisemitism, homophobia, democracy and totalitarianism, capital punishment and second chances, human rights, World War II, misogyny, tolerance and discrimination, Supermanism and humanism, artistic freedom and censorship. Subtly, often between the lines, and with Hitchcock's usual dark humor, Rope is nevertheless a much stronger social and political statement than it was ever given credit for. The Intertextual Knot is aimed at a varied readership, including film scholars, historians, philosophers and film enthusiasts.
The Jepson Manual
"More information is packed into one volume that will be useful to a wider audience than any other manual of this kind yet published in the history of botany."--David L. Magney, The California Native Plant Society "A single work . . . simultaneously accessible to dedicated beginners and indispensable to professional botanists. . . . For the first time in one volume a user-friendly flora of the exceedingly diverse higher plants of California."--Mildred E. Mathias, editor of Flowering Plants in the Landscape "Allows amateurs and professionals alike to easily and accurately identify plant species. . . . A product that will contribute in a major way to the preservation of California's unique floral resource. Our gratitude and congratulations for a job well done."--Phyllis Faber, Editor, Fremontia "Sets new standards for excellence . . . and picks up beautifully on the contemporary idea that botanical work should be fully accessible to the general public as well as to scientists."--Peter H. Raven, Missouri Botanical Garden "Precise and accurate, a masterpiece of clarity and succinctness."--G. Ledyard Stebbins, University of California, Davis
Cysticercosis of the Human Nervous System
Neurocysticercosis (neural infection by larvae of Taenia solium) occurs when humans become intermediate hosts of the tapeworm Taenia solium after ingesting its eggs. The disease is now the most common helminthic infection of the nervous system in humans, and its prevalence has risen significantly even in countries where it was formerly considered exotic. The introduction of modern neuroimaging and serologic techniques has improved the diagnosis of neurocysticercosis; furthermore, the development of potent cysticidal drugs has changed the prognosis of most affected patients. Nevertheless, much remains to be learned about this parasitic disease. This book provides a comprehensive and up-to-date review of the various aspects of cysticercosis of the nervous system that will be of interest to all who are involved in the care of patients with this disease. Epidemiology, neuropathology, immunopathogenesis, clinical manifestations, diagnosis, and management are all thoroughly discussed based on current evidence and practice.
Computer-Assisted Lead Finding and Optimization
Computer-assisted techniques are well-integrated in modern drug discovery and used for the finding of new leads, the optimization of receptor or enzyme affinity, as well as of pharmacokinetic and physicochemical properties. In this book an account is found of current strategies used in computer-assisted drug design. Important topics include progress in chemometrics, molecular modeling and three-dimensional QSAR approaches. Relatively new mathematical methods such as genetic algorithms or artificial neural networks and fuzzy logic have found their application in rational molecular design. As is amply illustrated, based on recent developments in these disciplines, important progress has been made in lead finding strategies. This is of great importance to the pharmaceutical industry. Thus, all scientists investigating quantitative structure-activity relationships in their broadest sense, in medicinal, agricultural, or environmental chemistry will benefit from this book.
