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Integrative Pharmacology-based Research on Traditional Medicine: Methodologies, Medical and Pharmacological Applications
ntegrative Pharmacology can be used to determine the multi-pharmacological effects of traditional medicines such as traditional Chinese medicine (TCM), Kampo, Sa-sang, Ayurveda, etc.). Through qualitative and quantitative pharmacokinetic-pharmacodynamic (PK-PD) correlations among multi-constituents and multi-targets, integrating chemical profiling, ADME/PK processes, molecular network calculation and resulting experimental validation, the use of Integrative Pharmacology has become widespread. The data has provided a novel paradigm to evaluate the druggability of bioactive ingredients of herbs or formulae, to decipher the pharmacological mechanisms of drug action and to screen potentially new indications for approved drugs and previously unidentified adverse events. On this basis, Integrative Pharmacology may offer an effective way to test the potential scientific basis for traditional medicines and to assess what roles of traditional medicine can and cannot play in pharmaceuticals.
Insights in Veterinary Pharmacology and Toxicology: 2023
We are now entering the third decade of the 21st Century, and, especially in the last years, the achievements made by scientists have been exceptional, leading to major advancements in the fast-growing field of Veterinary Pharmacology and Toxicology. Frontiers has organized a series of Research Topics to highlight the latest advancements in research across the specialty of Veterinary Pharmacology and Toxicology, with articles from the members of our accomplished Editorial Boards. This editorial initiative of particular relevance, led by Dr. Arturo Anadón, Specialty Chief Editor of the Veterinary Pharmacology and Toxicology section, is focused on new insights, novel developments, new tools f...
Proceedings of the 2023 International Conference on Economic Management, Financial Innovation and Public Service (EMFIPS 2023)
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Community Series in Antiviral Innate Immune Sensing, Regulation, and Viral Immune Evasion, volume II
This Research Topic is the second volume of the “Community Series in Antiviral Innate Immune Sensing, Regulation, and Viral Immune Evasion”. Please see the first volume here. The innate immune system is crucial to defend against viruses or other pathogenic microbes in the early phases of infection. The response starts with detecting evolutionarily conserved structures, termed pathogen-associated molecular patterns (PAMPs), by a set of germline-encoded pattern-recognition receptors (PRRs). Following the detection of specific viral PAMPs, PRRs trigger the activation of intracellular signaling cascades, ultimately leading to the induction of type I interferons (IFNs), pro-inflammatory cytok...
Chinese Archery
Chinese Archery is a broad view of traditional archery in China as seen through the eyes of historians, philosophers, poets, artists, novelists and strategists from 1500 BC until the present century. The book is written around parallel text translations of classical chinese sources some famous and some little known in which Chinese writers give vivid and detailed explanations of the techniques of bow-building, archery and crossbow technique over the centuries. The author is both a sinologist and practising archer; his translations make the original Chinese texts accessible to the non-specialist. Written for readers who may never have picked up a book about China, but still containing a wealth of detail for Chinese scholars, the book brings the fascinating history of Chinese archery back to life through the voices of its most renowned practitioners.
The Turquoise Monkey
On a rainy fall day when seven year old Jordan finds herself at home unable to play with her best friends, she daydreams of a cuddly constant companion to relieve her lonliness. She decides to draw her most desired companion in her favorite color, turquoise, and creates the turquoise monkey. This picture becomes her wish and obsession. Though Jordan never gives up hope, it seems unlikely her wish will ever come true.
Family Instructions for the Yan Clan and Other Works by Yan Zhitui (531–590s)
Yan Zhitui (531–590s) was a courtier and cultural luminary who lived a colourful life during one of the most chaotic periods, known as the Northern and Southern Dynasties, in Chinese history. Beginning his career in the southern Liang court, he was taken captive to the north after the Liang capital fell, and served several northern dynasties. Today he remains one of the best-known medieval writers for his book-length “family instructions” (jiaxun), the earliest surviving and the most influential of its kind. Completed in his last years, the work resembles a long letter addressed to his sons, in which he discusses a wide range of topics from family relations and remarriage to religious ...
His Majesty, Don't Offend Me
In order to protect the nine clans, her father had rebelled. In order to protect the world, she was willing to kill her father and kill her brothers! He applauded, "For love? You acted so well! " He fed her poison, he imprisoned her, he humiliated her, he held back his tears, she laughed! He grabbed her by the neck and shed bitter tears: Even if you abandoned my wife's remnants of flower, you could only die by my side ....
