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Sapporo, Otaru & Niseko Travel Guide
One of Japan’s most dynamic and newest cities, Sapporo is a spacious and laid-back place than you can imagine, with a number of fabulous parks, modern buildings, shopping malls, ski areas, dining and drinking options. It is a perfect place to explore if this is your first time in Hokkaido. As you leave the megacity of Sapporo, Central Hokkaido (simply called Dō-ō) is such a good distillation of all Hokkaido highlights that can be visited in a few days. It is an easily explored region on a short schedule and you can accessible a wide range of must-sees by public transport. The nostalgic port town of Otaru is the best destination from Sapporo if your time is limited. Japan’s most cosmo...
Drug Metabolism, Pharmacokinetics and Bioanalysis
Drug metabolism/pharmacokinetics and drug interaction studies have been extensively carried out in order to secure the druggability and safety of new chemical entities throughout the development of new drugs. Recently, drug metabolism and transport by phase II drug metabolizing enzymes and drug transporters, respectively, as well as phase I drug metabolizing enzymes, have been studied. A combination of biochemical advances in the function and regulation of drug metabolizing enzymes and automated analytical technologies are revolutionizing drug metabolism research. There are also potential drug–drug interactions with co-administered drugs due to inhibition and/or induction of drug metabolic enzymes and drug transporters. In addition, drug interaction studies have been actively performed to develop substrate cocktails that do not interfere with each other and a simultaneous analytical method of substrate drugs and their metabolites using a tandem mass spectrometer. This Special Issue has the aim of highlighting current progress in drug metabolism/pharmacokinetics, drug interactions, and bioanalysis.
Merde Actually
A year after arriving in France, Englishman Paul West is still struggling with some fundamental questions: _________________ What is the best way to scare a gendarme? Why are there no health warnings on French nudist beaches? And is it really polite to sleep with your boss's mistress? In his second comedy of errors, Paul West opens an English tearoom, and mutates (temporarily) into a Parisian waiter. Meanwhile, he continues his search for the perfect French mademoiselle. But will Paul find l'amour éternel, or will it all end in merde? Author's apology: 'I'd just like to say sorry to all the suppository fans out there, because in this book there are no suppositories. There are, however, lots of courgettes, and I see this as progress. Suppositories to courgettes - I think it proves that I'm developing as a writer.' Stephen Clarke
Occurrence, Distribution and Toxic Effects of Emerging Contaminantsx
Emerging contaminants include an extensive array of synthetic chemicals in global use, such as plastic additives, microplastics, water disinfection byproducts, pharmaceuticals, man-made nanomaterials, and UV-filters. Because of their extensive use in anthropogenic activities, these chemicals are entering the environment at alarming levels as hazardous wastes and non-biodegradable substances. This book emphasizes on the comprehensive information on emerging contaminants overview, environmental occurrence, analysis, risk assessment and toxicity assessment. Environmental, legal, health concerns of the ECs have also been covered in this book. The book also features an updated status from the industrial point of view.
Agent 49
Master thief is recruited by the government to spy on a plot to commit one of the greatest crimes in the 1940s. Billy Hathaway was just another thrill-seeking young man until he was involved in a drunken Saturday night brawl. After being thrown in jail, he is recruited by the government. His assignment is to keep an eye on a young scientist named Ted Hall who is working on the Manhattan Project. Eventually, Billy becomes a reluctant witness to the passing of the atomic bomb blueprint to Russia. Master thief is recruited by the government to spy on a plot to commit one of the greatest crimes in the 1940s. Billy Hathaway was just another thrill-seeking young man until he was involved in a drunken Saturday night brawl. After being thrown in jail, he is recruited by the government. His assignment is to keep an eye on a young scientist named Ted Hall who is working on the Manhattan Project. Eventually, Billy becomes a reluctant witness to the passing of the atomic bomb blueprint to Russia.
Programming Languages and Systems
This book constitutes the refereed proceedings of the 10th Asian Symposium on Programming Languages and Systems, APLAS 2012, held in Kyoto, Japan, in December 2012. The 24 revised full papers presented together with the abstracts of 3 invited talks were carefully reviewed and selected from 58 submissions. The papers are organized in topical sections on concurrency, security, static analysis, language design, dynamic analysis, complexity and semantics, and program logics and verification.
The Impossible State
The definitive account of North Korea - its veiled past and uncertain future - from former White House adviser and Korea expert Victor Cha ‘We killed Americans. We are killing Americans. We will kill Americans.’ North Korean schoolchildren conjugating verbs How did North Korea become The Impossible State, where citizens found humming South Korean pop songs risk being sent to a gulag, and yet a starving populace clings fiercely to its Dear Leader Kim Jong-un? What does the future hold for a regime with terrifying nuclear ambitions and an endless war with its southern counterpart? Former White House adviser and Director of Asian Studies at Georgetown University, Victor Cha, pulls back the ...
Combinatorial Optimization and Applications
The conference proceeding LNCS 11346 constitutes the refereed proceedings of the 12th International Conference on Combinatorial Optimization and Applications, COCOA 2018, held in Atlanta, GA, USA, in December 2018. The 50 full papers presented were carefully reviewed and selected from 106 submissions. The papers cover most aspects of t graph algorithms, routing and network design problems, scheduling algorithms, network optimization, combinatorial algorithms, approximation algorithms, paths and connectivity problems and much more.
Back Running
“It’s 2025, and a tech war between the U.S., Russia and China has culminated in the collapse of power grids across the world with technology becoming obsolete.” A young high school football coach and his family watch helplessly as their power grid goes down — with no warning. They can’t access their bank to get any money, they can’t call the police when they hear people breaking into houses in their neighborhood. They can’t buy gas for their generator and as they’re cleaning out what’s left to eat in the refrigerator, Coach comes up with a plan. His father had left him a cabin in the woods in South Carolina. They could go there and get away from the looting to survive by hunting and fishing. There were fruit trees on the property and they had planted blackberry bushes a couple years ago that should be producing by now. Little did they know how soon foreign powers would have them in their cross hairs and would do anything to steal their secret.”
Vector
Dr. Jack Stapleton and Dr. Laurie Montgomery must race against the clock to prevent an unthinkable catastrophe in this “frightening” (Publishers Weekly) novel from the #1 New York Times bestselling author hailed as “the master of the medical thriller” (The New York Times). Experts do not question whether a bio-terrorism event will occur in the United States, only when. . . . New York City cab driver Yuri Davydov is an angry, disillusioned Russian émigré poised to lash out at the adoptive nation he believes has denied him the American Dream. A former technician for the vast Soviet biological weapons system, Yuri possesses the technical knowledge to carry out his vengeance on a horri...
