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This book represents proceedings of the 19th American Peptide Symposium. It highlights many of the recent developments in peptide science, with a particular emphasis on how these advances are being applied to basic problems in biology and medicine. Specific topics covered include novel synthetic strategies, peptides in biological signaling, post-translational modifications of peptides and proteins, and peptide quaternary structure in material science and disease.
Frontiers in Medicinal Chemistry is an E-book series devoted to reviews on research topics relevant to medicinal chemistry and allied disciplines. Frontiers in Medicinal Chemistry covers developments in rational drug design, bioorganic chemistry, high-throughput screening, combinatorial chemistry, compound diversity measurements, drug absorption, drug distribution, metabolism, new and emerging drug targets, natural products, pharmacogenomics, chemoinformatics, and structure-activity relationships. This E-book series is essential for any medicinal chemist who wishes to be updated on the latest and the most important advances in the field. This volume features reviews on the following topics: • Purinergic receptors and pain • Cytochrome c – cardiolipin interactions in cells • Dipeptidyl peptidase-4 (CD26) functions and inhibition • Peptides regulating angiogenesis • Application of melanotropin ligands for the treatment of obesity and related disorders • Targeted drugs in the field of nanomedicine
“Have you tried peptides? Small proteins, the best in the land! Won’t you try peptides? Keep all your body processes in hand! For labor and lactation oxytocin you must buy! Enkephalin always gives a good runner’s high! So won’t you try peptides? Small proteins, the best in the land!” The above words [1], penned by Gary Gisselman to open Peptide Ångst: La Triviata, the opera which made its world premiere on July 1, 1999, also serve as a fitting charge to the th 16 American Peptide Symposium. This latest edition of a premier biennial series was held under the auspices of the American Peptide Society, June 26–July 1, 1999, at the Minneapolis Convention Center, Minneapolis,Minnesota...
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Presenting a wide array of information on chemical ligation – one of the more powerful tools for protein and peptide synthesis – this book helps readers understand key methodologies and applications that protein therapeutic synthesis, drug discovery, and molecular imaging. • Moves from fundamental to applied aspects, so that novice readers can follow the entire book and apply these reactions in the lab • Presents a wide array of information on chemical ligation reactions, otherwise scattered across the literature, into one source • Features comprehensive and multidisciplinary coverage that goes from basics to advanced topics • Helps researchers choose the right chemical ligation technique for their needs
The book covers all uncommon ulcers of the extremities which remain a difficult diagnosis for clinicians most of the times. A variety of causes like metabolic, infective, rheumatoid, drug induced or inflammation may lead to ulcerations. Diagnosis of these ulceration is difficult as these diseases are systemic, and treatment is carried out by physicians but ulcers are managed by the surgeons. Any lacunae or gap in assessment or work-up may lead to failure in diagnosis and increased morbidity. This book provides a systematic and step wise approach to the differential diagnosis of every possible uncommon ulcers in the extremities with detailed work-up, flow chart and summary. The book is system...
This book presents the current knowledge on the mechanisms by which exercise lowers blood pressure in hypertension and on its effects on the heart and arteries. In addition, it focuses on the optimal exercise protocols, the international consensus on clinical implementation, and the clinical indications for special populations (obese, diabetic etc). It also addresses possible drawbacks of exercise on left ventricular structure and function. Many experts in epidemiology, patophysiology and clinical research have contributed in preparing the chapters, with the main purpose of guiding clinicians in the optimal application of the present knowledge and to stimulate scientists to fill the gaps in knowledge by performing further research.The book is addressed not only to specialists in Hypertension, Internal Medicine, Cardiology, Metabolism, and Nephrology, but also to general practitioners and all healthcare professionals working in the field of rehabilitation medicine.