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Never-resting microglia: physiological roles in the healthy brain and pathological implications
Microglia are largely known as the major orchestrators of the brain inflammatory response. As such, they have been traditionally studied in various contexts of disease, where their activation has been assumed to induce a wide range of detrimental effects. In the last few years, a series of discoveries have challenged the current view of microglia, showing their active and positive contribution to normal brain function. This Research Topic reviewed the novel physiological roles of microglia in the developing, mature and aging brain, under non-pathological conditions. In particular, this Research Topic discussed the cellular and molecular mechanisms by which microglia contribute to the formati...
Microglia in Health and Disease
These past few years have witnessed a revolution in our understanding of microglia, especially since their roles in the healthy central nervous system (CNS) have started to unravel. These cells were shown to actively maintain health, in concert with neurons and other types of CNS cells, providing further insight into their involvement with diseases. Edited by two pioneers in the field, Marie-Ève Tremblay and Amanda Sierra, Microglia in health and disease aims to share with the broader scientific community some of the recent discoveries in microglia research, from a broad perspective, with a collection of 19 chapters from 52 specialists working in 11 countries across 5 continents. To set mic...
Phagocytosis: Molecular Mechanisms and Physiological Implications
This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact.
Generation of Neurons and Their Integration in Pre-Existing Circuits in the Postnatal Brain: Signalling in Physiological and Regenerative Contexts
This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact.
Understanding the Roles of Glia and Circulating Leukocytes in Neurodegenerative Diseases
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Everything Is Just Yesterday with Lots of Tomorrows
This is a fi ctional tale that contains slight spiritual messages and subtle social issues sprinkled into it. It is a love story between a young angry hateful shrimper who lives in the village of Edgewater which is located along the St. Johns River in northern Florida and a young Gullah woman who is from St. Helena Island off the Beaufort coast of South Carolina. A boating accident occurs out in the Atlantic Ocean in which Billie Barrett is washed ashore on Hunting Island, South Carolina. After medical attention is given to Billie he is taken in and cared for by a Gullah family living in St. Helena Island. It is in this household that he meets Bridgette Kamau who tends to him on a day to day basis. A connection is made between the two and Billie has a change of heart in his ignorance as he falls in love with her. You will read into it what you will and get out of it what you perceive.
The Role of Glia in Alzheimer's Disease
We believe that the role of glia is the next frontier to be explored in Alzheimer’s disease research. This eBook is an update on both the current knowledge of astrocytes and microglia involvement in Alzheimer’s disease pathophysiology, and some of the techniques available to study them.
Religion, Tradition, and Restorative Justice in Sierra Leone
In this groundbreaking study of post-conflict Sierra Leone, Lyn Graybill examines the ways in which both religion and local tradition supported restorative justice initiatives such as the national Truth and Reconciliation Commission (TRC) and village-level Fambul Tok ceremonies. Through her interviews with Christian and Muslim leaders of the Inter-Religious Council, Graybill uncovers a rich trove of perspectives about the meaning of reconciliation, the role of acknowledgment, and the significance of forgiveness. Through an abundance of polling data and her review of traditional practices among the various ethnic groups, Graybill also shows that these perspectives of religious leaders did not...
The Vagus-Immune Connection
This comprehensive guide delves into the intricate relationship between the vagus nerve and immune regulation, providing invaluable insights and practical strategies for understanding chronic illnesses like migraine, anxiety, BPD, cognitive dysfunction, stroke, hypertension, IBS, and more. Engineer, inventor, and vagus nerve expert J. P. Errico distills the latest scientific research and technological advancements to offer an easy-to-understand guide to bolstering your immune system and enhancing resilience against pathogens and diseases. With The Vagus-Immune Connection, you will: Gain a deep understanding of how the vagus nerve influences the immune system, from its role in controlling inflammation to its impact on autoimmune conditions; Discover practical techniques to effectively manage stress, a major contributor to immune dysregulation; Enhance immune resilience and disease prevention; Optimise cellular energy metabolism to improve neurodevelopment and cognitive function. Whethe
