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Environmental Stressors and OxInflammatory Tissues Responses
Environmental risk factors – noise, air pollution, chemical agents, and ultraviolet radiation – impact human health by contributing to the onset and progression of noncommunicable diseases. Accordingly, there is need for preclinical and clinical studies and comprehensive summary of major findings. This book is a state-of-the-art summary of these myriad severe life stressors. The chapters on the different pollutants focus on disease mechanisms (cardiovascular, neurological and metabolic disorders) and on oxidative stress and inflammation. The editors emphasize emerging mechanisms based on dysregulation of the circadian clock, the microbiome, epigenetic pathways, and cognitive function by environmental stressors, and introduce the exposome concept while highlighting existing research gaps. Key Features: Links various environmental stressors to the incidence of noncommunicable diseases Includes chapters on airborne toxins, chemical pollutants, noise, and ultraviolet radiation stressors Contributions from an international team of leading researchers Summarizes the impacts of stressors on disease mechanisms
The role of bile pigments in health and disease: effects on cell signaling, cytotoxicity and cytoprotection
Degradation of heme involves its conversion to biliverdin by heme oxygenase followed by reduction of biliverdin to bilirubin by biliverdin reductase. There is ample evidence for the pleiotropic functions of biliverdin reductase in cell signaling and regulation of gene expression. This enzyme plays a major role in glucose uptake and the stress response. Bilirubin has been shown to behave as a "double-edged sword". It can exert either cytotoxic or cytoprotective effects, depending on the blood and/or tissue concentration of its free fraction, the nature of the target cell or tissue, and the cellular redox state. Its antioxidant effect is the basis for the proposed cardioprotective effect of relatively low blood concentrations of bilirubin in humans with moderate hyperbilirubinemia. This Special Topic forum is intended to serve as a platform for updating information and presenting advances in basic and clinical research in the above and related subjects.
The Knight without Boundaries: Yiddish and German Arthurian Wigalois Adaptations
Explores a core medieval myth, the tale of an Arthurian knight called Wigalois, and the ways it connects the Yiddish-speaking Jews and the German-speaking non-Jews of the Holy Roman Empire.
The Dynamic Nature of Mitochondria
Mitochondrial research has exploded over the last ~150 years. This book gives an amazing view on a conceptual change in our understanding of mitochondrial biology. It becomes clear that mitochondria are extremely dynamic in nature, controlling life at multiple levels. Mitochondria rule energy conversion, adapt cells well to changing stress and nutrient conditions, and regulate many cellular processes including immunity. The dynamic nature of mitochondria occurs at an intramitochondrial level but also includes its ability to interact with other organelles and to modulate multiple signalling pathways. It is thus not surprising that alterations or inabilities to ensure this dynamic behaviour is...
The Vasculome
The Vasculome: From Many, One introduces the fundamental bases of the “unity in diversity of the Vasculome, from the coming together of various cell lineages during development, to its deceptively simple solution for architectural design: the efficient interplay of a few types of building blocks supporting key similar functions throughout the body and their highly specialized functional local variations. Specific examples are included to illustrate how the Vasculome is integral to the function and malfunction of different organs, such as the brain or the kidney. Each section is preceded by an introductory summary that will give a high level unified view of the key concepts illustrated in t...
Occupational and environmental health in middle-aged and older adults
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Mitochondrial Dysfunction in Ageing and Diseases
This book is a printed edition of the Special Issue "Mitochondrial Dysfunction in Ageing and Diseases" that was published in IJMS
Aging and Age-Related Disorders
Features that characterize the aging process include the gradual accumulation of cell damage after prolonged exposure to oxidative and inflammatory events over a lifetime. In addition to the accretion of lesions, the intrinsic levels of pro-oxidant and aberrant immune responses are elevated with age. These adverse events are often further enhanced by the chronic and slow progressing diseases that characterize the senescent brain and cardiovascular system. The incidence of some disorders such as Alzheimer's disease and vascular diseases are sufficiently prevalent in the extreme elderly that these disorders can arguably be considered "normal". Aging and Aging-Related Disorders examines the int...
Energy Transition
This book presents both the importance of energy transition and its associated difficulties. Energy Transition, Second Edition, provides an explanation of the physical concepts of energy and power and also reviews global energy consumption and our dependence on energy. The book discusses the links between the economy and energy. It explains the drawbacks and dangers of different energy sources and tries to compare them. By reviewing future energy resources, it evaluates several transition scenarios. The book shows that the laws of physics prevent the emergence of simple, pleasant solutions, but it proposes potential solutions and encourages readers to develop better processes from energy sou...
Citizens of Worlds
An unparalleled how-to guide to citizen-sensing practices that monitor air pollution Modern environments are awash with pollutants churning through the air, from toxic gases and intensifying carbon to carcinogenic particles and novel viruses. The effects on our bodies and our planet are perilous. Citizens of Worlds is the first thorough study of the increasingly widespread use of digital technologies to monitor and respond to air pollution. It presents practice-based research on working with communities and making sensor toolkits to detect pollution while examining the political subjects, relations, and worlds these technologies generate. Drawing on data from the Citizen Sense research group...
