Seems you have not registered as a member of localhost.saystem.shop!
You may have to register before you can download all our books and magazines, click the sign up button below to create a free account.
Solid-Phase Organic Syntheses, Volume 1
The rapid expansion of combinatorial chemistry has renewed interest in solid-phase organic synthesis, a method that lends itself well to creating and screening large numbers of lead compounds. Solid-Phase Organic Syntheses, Volume 1 is the first volume in a series that will be updated annually, filling a gap in the existing chemical literature. Providing information previously unavailable from a single resource, this series is dedicated to providing researchers in the field with validated and tested methods for the solid-phase synthesis of interesting and biologically relevant molecules. Solid-phase methods will virtually always be invented for application in combinatorial organic synthesis....
Combinatorial Chemistry
The new time-saving revolution in drug discovery. Combinatorial chemistry, a method for synthesizing millions of chemical compounds much faster than usual, is becoming one of the most useful technical tools available to chemists and researchers working today. Using current advances in computer and laboratory techniques, combinatorial chemistry has freed professionals from the drudgery of piecemeal experimental work and opened new creative possibilities for experimentation. Combinatorial Chemistry: Synthesis and Application details critical aspects of the technique, featuring the work of some of the world's leading chemists, many of whom played a key role in its development. Including example...
High Throughput Screening
Furnishing the latest interdisciplinary information on the most important and frequently the only investigational system available for discovery programs that address the effects of small molecules on newly discovered enzyme and receptor targets emanating from molecular biology, this timely resource facilitates the transition from classical to high throughput screening (HTS) systems and provides a solid foundation for the implementation and development of HTS in bio-based industries and associated academic environments.
Supramolecular Materials and Technologies
Perspectives in Supramolecular Chemistry relates recent developments and new exciting approaches in supramolecular chemistry. The series covers all areas from theoretical and modelling aspects through organic and inorganic chemistry and biochemistry to materials, solid-state and polymer sciences reflecting the many and varied applications of supramolecular structures in modern chemistry. From the early days of supramolecular chemistry the field has been associated with possible applications. This is not surprising as the design of new molecules, and later of assemblies of molecules, is often function-driven. Now, after three decades of supramolecular chemistry, David Reinhoudt has brought to...
More Than a Memoir
In this unusual autobiography you will find the full story of a life spanning much of the twentieth century. Selective reading will disclose How a teacher/scientist may develop The importance of focus and integrity The fascination of doing chemical and biochemical research with students and colleagues The excitement of discovery and of facing new challenges Personal details about family life and friendships Career choices and diversions Plus In the 23 (!) appendices, you will find details concerning Other activities attendant upon a career in science The influence of conferences, symposia, and international scientific connections The coworkers who built the reputation of the author
High-Throughput Analysis in the Pharmaceutical Industry
The introduction of combinatorial chemistry technology has increased the amount of compounds generated in a year from 50 to 2000. Conventional analytical approaches simply cannot keep up. These circumstances have caused drug discovery to take on the shape of a bottleneck, like traffic through a toll booth. In order to break the bottleneck, a corres
Fluorescent Chemosensors
Fluorescent chemosensors have been widely applied in many diverse fields such as biology, physiology, pharmacology, and environmental sciences. The interdisciplinary nature of chemosensor research has continued to grow over the last 25 years to meet the increasing needs of monitoring our environment and health. More recently, a large range of fluorescent chemosensors have been established for the detection of biologically and/or environmentally important species, and are increasingly being used to solve biological problems. The use of these molecules as imaging probes to diagnose and treat disease is gaining momentum with clear future applications. This book will bring together world-leading experts to describe the current state of play in the field and introduce the cutting-edge research and possible future directions into fluorescent chemosensors design. Chapters focus on the basic principles involved in the design of chemosensors for specific analytes, problems, and challenges in the field. Concentrating on advanced techniques and methods, the book will be of use for academics and researchers across a number of disciplines, with international appeal.
Topics in Fluorescence Spectroscopy
Time-resolved fluorescence spectroscopy is widely used as a research tool in bioch- istry and biophysics. These uses of fluorescence have resulted in extensive knowledge of the structure and dynamics of biological macromolecules. This information has been gained by studies of phenomena that affect the excited state, such as the local environment, quenching processes, and energy transfer. Topics in Fluorescence Spectroscopy, Volume 4: Probe Design and Chemical Sensing reflects a new trend, which is the use of time-resolved fluorescence in analytical and clinical chemistry. These emerging applications of time-resolved fluorescence are the result of continued advances in laser detector and computer technology. For instance, pho- multiplier tubes (PMT) were previously bulky devices. Miniature PMTs are now available, and the performance of simpler detectors is continually improving. There is also considerable effort to develop fluorophores that can be excited with the red/ne- infrared (NIR) output of laser diodes. Using such probes, one can readily imagine small time-resolved fluorometers, even hand-held devices, being used fordoctor’s office or home health care.
