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Protein Kinase-mediated Decisions Between Life and Death
Protein phosphorylation via protein kinases is an inevitable process that alters physiological and pathological functions of the cells. Thus, protein kinases play key roles in the regulation of cell life or death decisions. Protein kinases are frequently a driving factor in a variety of human diseases including aging and cellular senescence, immune system and endothelial dysfunctions, cancers, insulin resistance, cholestasis and neurodegenerative diseases, as well as bacterial resistance in persistent infections. Recent developments in quantitative proteomics provide important opinions on kinase inhibitor selectivity and their modes of action in the biological context. Protein Kinase-mediated Decisions Between Life and Death aims to have the reader catch insights about up-to-date opinions on “Protein Kinases” related pathways that threaten human health and life. As “Protein Kinases” are related to many health problems, clinicians, basic science researchers and students need this information. Chapter “Signal Transduction in Immune Cells and Protein Kinases” is available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.
Obesity and Lipotoxicity
This book is a comprehensive review of the recent research on the lipotoxicity-related mechanisms in obesity and the development of new treatment strategies. In this second edition, the possible molecular treatment methods and their recent clinical approaches are discussed in addition to the basic mechanisms that are available and thoroughly reviewed previously. Moreover, all chapters have been reviewed, according to the current concepts and seven new chapters are added, covering obesity-related epigenetic modifications, senescence, obesity-related cancer development, endocrine disruptors, as well as nanotechnology-based clinical approaches. This book is an essential resource for clinicians and basic science researchers, such as biochemists, toxicologists, immunologists, nutritionists, adult and pediatric endocrinologists, and cardiologists, as well as all researchers or students who want to learn the mysteries of obesity.
The Oxford Handbook of Ancient Anatolia
This title provides comprehensive overviews on archaeological philological, linguistic, and historical issues at the forefront of Anatolian scholarship in the 21st century.
Nanoneuroprotection and Nanoneurotoxicology
Nanoneuroprotection and Nanoneurotoxicology, Volume 245, deals with recent developments in the field of neurotoxicity and neuroprotection using nanobiotechnology for the first time. Chapters in this updated release include Sleep deprivation induced brain pathology and concussive head trauma-Neuroprotective effects of nanowired delivery of drugs and hormones, Nanomedicine in Alzheimer’s Disease: amyloid beta targeting strategy, How traumatic brain injury alters amino acids balance in the central nervous system-Neuroprotection by TiO2 nanowired delivery of drugs and antibodies, Nanowired delivery of DL-3-n-butylphthalide and neuroprotection in concussive head injury, Nanodelivery of drugs and antibodies for superior neuroprotection in Alzheimer’s disease, and more. Highlights recent development in nanopharmacetical research with reference to brain disease Provides new insights on the possible role of nanomaterials and their pronounced effects on CNS injury or repair
Hittite Landscape and Geography
Hittite Landscape and Geography provides a holistic geographical perspective on the study of the Late Bronze Age Hittite Civilization from Anatolia (Turkey) both as it is represented in Hittite texts and modern archaeology.
Endothelium
The function and life span of endothelial cells have a large impact upon the quality and expectancy of an individual's life. During low perfusion, the adaptation of different cells to hypoxia precipitate the aggressive progression of diseases. Although the clinical studies have convincingly shown that endothelial dysfunction occurs whenever the biological functions or bioavailability of nitric oxide are impaired, in all these scenarios, the role of endothelial cell-destructive process cross-talk is yet poorly understood. This book focuses on the contribution of molecular mechanisms to endothelial dysfunction in related metabolic disorders.
My Food My Health
Despite the dramatic developments in medical science, the health of the population worldwide has largely been on a decline and diseases have been found to be affecting people much earlier in life than before. This, in a large part, is affected by our dietary habits and patterns. My Food, My Health is an extremely accessible manual to healthy eating and healthful living through balanced nutrition, which compiles the wisdom of expert dieticians from the Apollo Group. Geared to cater to everyone-from toddlers and adolescents to mothers-to-be and senior citizens-this guide serves as a ready reckoner for healthcare professionals as well as the common man. It busts the myths and facts about various common diseases that pose serious public health challenges in India at the moment, such as obesity, diabetes, high blood cholesterol, high blood pressure, heart disease and cancer. Abundant in practical lifestyle changes and easy recipes to help you cook healthy food at home, this book will aid you in understanding and confidently managing your health better, so you can live a happy, healthy life!
The Note from Heaven
Githa Ben-David presents a method for liberating the natural voice using regressive cell singing - one of the most direct ways to get in contact with the subconscious mind. This liberation has a healing effect on body and soul and can be experienced by every speaking person. With inspiration from India, Githa has put together a program for self-study, along with a practice instruction program that can be downloaded. Utilising this method you will 'sing yourself free from traumas that have their origin in this life, the womb or previous lifetimes. In regressive cell singing, The Note from Heaven is used as a tuning fork to retune cells to their former harmony. Any notes, sounds or outbursts that genuinely express The Note from Heaven can release blocked energy imprisoned in the Singer?s body as trauma. The process starts a cell-dance, which reorganizes the body back to it's original balanced matrix. Transform your life through the power of sound. In the beginning there was sound. With sound everything was created. You are sound.
The Fountain of Woof
What is the Fountain of Woof? In this first-of-a-kind book for dogs and their people, Dr. Franklin Utchen, a small animal veterinarian with over 35 years of experience in daily practice, helps answer that question. Based on exhaustive research in dogs, humans, mice, and more, he details the leading-edge knowledge about the science of longevity as it applies to our dogs. Dr. Utchen explains in common terms why an animal ages and discusses the simple “longevity” meds that a pet caretaker can start giving today to help a dog live his or her life as long and healthy as possible. If you want to know the latest information about how to help an old dog live younger, and a young dog live younger longer, then this book is for you and your pup.
