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CAR-T Cell Therapies for Non-Hematopoietic Malignancies: Taking Off The Training Wheels
Chimeric antigen receptor (CAR) T cell therapies for leukemia (e.g. tisagenlecleucel) and lymphoma (e.g. axicabtagene ciloleucel) have recently received regulatory approval in the United States. Phase I/II trials have demonstrated complete remission of refractory or relapsed tumors in 50% - 94% patients. However, the clinical successes of engineered T cells for the treatment of solid malignancies have thus far been few and far between. Furthermore, several instances of severe and lethal toxicities have arisen due to on-target, off-tumor recognition of antigen by T cell products. Recent advances in phase I trials for solid tumors, as well as in pre-clinical models, have revealed several varia...
Official Gazette of the United States Patent and Trademark Office
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Congressional Record
The Congressional Record is the official record of the proceedings and debates of the United States Congress. It is published daily when Congress is in session. The Congressional Record began publication in 1873. Debates for sessions prior to 1873 are recorded in The Debates and Proceedings in the Congress of the United States (1789-1824), the Register of Debates in Congress (1824-1837), and the Congressional Globe (1833-1873)
Guide to United States Naval Administrative Histories of World War II
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Who's who Among African Americans
Devoted to recording the scope of African American achievement, reference provides biographical and career details on more than 20,000 notable African American individuals, including leaders from sports, the arts, business, religion and more. An obituary section contains fully updated entries for listees who have died since the previous edition.
