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This book presents the latest advances concerning the regulation of chromosome segregation during cell division by means of centromeres and kinetochores. The authors cover both state-of-the-art techniques and a range of species and model systems, shedding new light on the molecular mechanisms controlling the transmission of genetic material between cell divisions and from parent to offspring. The chapters cover five major areas related to the current study of centromeres and kinetochores: 1) their genetic and epigenetic features, 2) key breakthroughs at the molecular, proteomic, imaging and biochemical level, 3) the constitutive centromere proteins, 4) the role of centromere proteins in the physical process of chromosome segregation and its careful orchestration through elaborate regulation, and 5) intersections with reproductive biology, human health and disease, as well as chromosome evolution. The book offers an informative and provocative guide for newcomers as well as those already acquainted with the field.
Although the Bene Israel community of western India, the Baghdadi Jews of Bombay and Calcutta, and the Cochin Jews of the Malabar Coast form a tiny segment of the Indian population, their long-term residence within a vastly different culture has always made them the subject of much curiosity. India is perhaps the one country in the world where Jews have never been exposed to anti-Semitism, but in the last century they have had to struggle to maintain their identity as they encountered two competing nationalisms: Indian nationalism and Zionism. Focusing primarily on the Bene Israel and Baghdadis in the late nineteenth and twentieth centuries, Joan Roland describes how identities begun under t...
Few of Dr. Ben's books are written with co-authors. The Black Man's North and East Africa is an exception. Written with one of his early colleagues, George E. Simmonds, this work attacks the racist manipulation of African and Black history by 'educators' and 'authorities on Africa'. Defenders of the Africans' right to tell their own story, the authors insist that Black people must take responsibility for their own history, "Until African (Black) people are willing, and do write their own experience, past, and present, we will continue being slaves, mentally, physically, and spiritually, to Caucasian and Semitic racism and religious bigotry."
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The centromere is a chromosomal region that enables the accurate segregation of chromosomes during mitosis and meiosis. It holds sister chromatids together, and through its centromere DNA–protein complex known as the kinetochore binds spindle microtubules to bring about accurate chromosome movements. Despite this conserved function, centromeres exhibit dramatic difference in structure, size, and complexity. Extensive studies on centromeric DNA revealed its rapid evolution resulting often in significant difference even among closely related species. Such a plasticity of centromeric DNA could be explained by epigenetic c- trol of centromere function, which does not depend absolutely on prima...
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Reprint of the original, first published in 1857. The publishing house Anatiposi publishes historical books as reprints. Due to their age, these books may have missing pages or inferior quality. Our aim is to preserve these books and make them available to the public so that they do not get lost.