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Toxicity Assessment
This book collects protocols from different areas of knowledge to assist in the identification of toxic effects exerted by different xenobiotics. At the same time as classical techniques are presented, modern techniques with alternative models to the use of animals are also presented. Given the ever-increasing exposure to different compounds and their effects on population health, the assessment of multiple endpoints is of utmost importance for better risk assessment, and this collection addresses that need. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Toxicity Assessment: Methods and Protocols aims to serve researchers in this vast field of science as they seek to better understand the mechanisms of action of different xenobiotics.
Mitochondrial Bioenergetics
Increasing interest in mitochondrial bioenergetics is being driven by the impact of drug and environmental chemical-induced disturbances of mitochondrial function as well as hereditary deficiencies and the progressive deterioration of bioenergetic performance with age. These initiatives have fostered the investigation of genetic and environmental influences on bioenergetics. In Mitochondrial Bioenergetics: Methods and Protocols, researchers in the field detail the practical principles and assays designed to derive quantitative assessment of each set of parameters that reflect different aspects of mitochondrial bioenergetics. Written in the highly successful Methods in Molecular BiologyTM series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and key tips on troubleshooting and avoiding known pitfalls Authoritative and practical, Mitochondrial Bioenergetics: Methods and Protocols helps elevate the quality and rate of investigative discoveries regarding disease states associated with environmental or genetic influences on mitochondrial bioenergetics.
Nutraceuticals
Nutraceuticals: Efficacy, Safety and Toxicity, Second Edition, brings together everything that is currently known about nutraceuticals and their potential toxic effects. The book introduces readers to nutraceuticals, herbal medicines, Ayurvedic medicines, prebiotics, probiotics, adaptogens, and their uses and specific applications. This essential reference discusses the mechanism of action for the judicious use of these nutraceuticals and the best tools for their evaluation before detailing the safety and toxicity of nutraceuticals and interactions with other therapeutic drugs. Finally, and crucially, regulatory aspects from around the world are covered. Completely revised and updated, this ...
Anti-obesity Drug Discovery and Development
Obesity is a complex health problem, caused by a number of factors such as excessive food intake, lack of physical activity, genetic predisposition, endocrine disorders, medications and psychiatric illnesses. The incidence of obesity among populations in both the developing and the developed world has reached epidemic proportions. In response to this, efforts to control and treat obesity have also been vigorously pursued, ranging from activities focused on raising awareness about lifestyle changes to the discovery and development of safe and effective anti-obesity drugs. Anti-obesity Drug Discovery and Development is a book series focused on this very important area of healthcare research. E...
From Fundamentals to Applications in Geotechnics
The work of geotechnical engineers contributes to the creation of safe, economic and pleasant spaces to live, work and relax all over the world. Advances are constantly being made, and the expertise of the profession becomes ever more important with the increased pressure on space and resources. This book presents the proceedings of the 15th Pan-American Conference on Soil Mechanics and Geotechnical Engineering (XV PCSMGE), held in Buenos Aires, Argentina, in November 2015. This conference, held every four years, is an important opportunity for international experts, researchers, academics, professionals and geo-engineering companies to meet and exchange ideas and research findings in the ar...
Deformation Characteristics of Geomaterials
In November 2015, Buenos Aires, Argentina became the location of several important events for geo-professionals, with the simultaneous holding of the 6th International Symposium on Deformation Characteristics of Geomaterials, the 15th Pan-American Conference on Soil Mechanics and Geotechnical Engineering (XV PCSMGE), the 8th South American Congress on Rock Mechanics (SCRM), as well as the 22nd Argentinean Congress of Geotechnical Engineering (CAMSIGXXII). This synergy provided a unique opportunity to exchange ideas and discuss current and future practices in the areas of soil mechanics and rock mechanics, and their applications in civil, energy, environmental, and mining engineering. This bo...
The Atlantic Forest
The Atlantic Forest is one of the 36 hotspots for biodiversity conservation worldwide. It is a unique, large biome (more than 3000 km in latitude; 2500 in longitude), marked by high biodiversity, high degree of endemic species and, at the same time, extremely threatened. Approximately 70% of the Brazilian population lives in the area of this biome, which makes the conflict between biodiversity conservation and the sustainability of the human population a relevant issue. This book aims to cover: 1) the historical characterization and geographic variation of the biome; 2) the distribution of the diversity of some relevant taxa; 3) the main threats to biodiversity, and 4) possible opportunities to ensure the biodiversity conservation, and the economic and social sustainability. Also, it is hoped that this book can be useful for those involved in the development of public policies aimed at the conservation of this important global biome.
Geotechnical Synergy in Buenos Aires 2015
In November 2015, Buenos Aires, Argentina became the location of several important events for geo-professionals, with the simultaneous holding of the 15th Pan-American Conference on Soil Mechanics and Geotechnical Engineering (XV PCSMGE), the 8th South American Congress on Rock Mechanics (SCRM) and the 6th International Symposium on Deformation Characteristics of Geomaterials, as well as the 22nd Argentinean Congress of Geotechnical Engineering (CAMSIGXXII). This synergy brought together international experts, researchers, academics, professionals and geo-engineering companies in a unique opportunity to exchange ideas and discuss current and future practices in the areas of soil mechanics and rock mechanics, and their applications in civil, energy, environmental, and mining engineering. This book presents the invited lectures of the 15th Pan-American Conference on Soil Mechanics and Geotechnical Engineering (XV PCSMGE) and the 8th South American Congress on Rock Mechanics (SCRM). It includes the Casagrande Lecture delivered by Luis Valenzuela and 21 Plenary, Keynote and Panelist Lectures from these two Buenos Aires conferences.
