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This textbook provides a fresh, comprehensive and accessible introduction to the rapidly expanding field of molecular pharmacology. Adopting a drug target-based, rather than the traditional organ/system based, approach this innovative guide reflects the current advances and research trend towards molecular based drug design, derived from a detailed understanding of chemical responses in the body. Drugs are then tailored to fit a treatment profile, rather than the traditional method of ‘trial and error’ drug discovery which focuses on testing chemicals on animals or cell cultures and matching their effects to treatments. Providing an invaluable resource for advanced under-graduate and MSc...
A major work by a brilliant young biographer, Muckraker details the tenacity and verve of one of Victorian Britain's most compelling characters. Credited with pioneering investigative reporting, W. T. Stead made a career of 'muckraking': revealing horrific practices in the hope of shocking authorities into reform. As the editor of the Northern Echo, he won the admiration of the Liberal statesman William Gladstone for his fierce denunciation of the Conservative government; at the helm of London's most ininfuential evening paper, the Pall Mall Gazette, he launched the career-defining Maiden Tribute campaign. To expose the scandal of child prostitution, Stead abducted thirteen-year-old Eliza Armstrong (thought by many to be the inspiration behind Eliza Doolittle, from friend George Bernard Shaw's Pygmalion), thrusting him into a life of notoriety. Labelled a madman in later life for dabbling in the occult, W. T. Stead conducted his life with an invincible zeal right up until his tragic demise aboard the Titanic. Revealing a man full of curious eccentricities, W. Sydney Robinson charts the remarkable rise and fall of a true Fleet Street legend in this enthralling biography.
The past 30 years have witnessed a dramatic improvement in life expectancy and quality of life for patients with cystic fibrosis. As a consequence, cystic fibrosis is no longer a paediatric disease. In Western Europe and North America 20% of patients are adults. Some adult cystic fibrosis patients have graduated from universities, some have jobs, some are married, and have children. Consequently, the spectrum of symptoms and complications of the basic disease changes. It is important that clinicians recognize the specifically adult related problems and that this knowledge is conveyed to their colleagues. At the same time, the progress of basic science such as genetics, physiology of membranes and immunology have rapidly progressed, all making an impact towards the best possible care for patients. These Proceedings of the 17th Working Group for Cystic Fibrosis provide a wealth of new information in the basic science and clinical treatment of cystic fibrosis. Chapters written by internationally established scientists are provided, which should prove to be of value for paediatricians, chest physicians, microbiologists, and scientists working with cystic fibrosis patients.
Random Wisdom is a collection of thoughts and insights from some of the greatest minds of modern and ancient times, painstakingly collected and compiled by one man in his unquenchable thirst for knowledge. This collection of literary tidbits will educate, inspire, and entertain the reader with its wide range of subjects, wit, and timeless anecdotes. As the title suggests, the information presented is randomly organized and is meant to serve as an inspirational reference book. The thousands of entries are designed to inspire deeper thinking and inward reflection, with many offering a healthy dose of wit and humor as well.
Winner of the 2019 Broken Frontier Award for Best Book on Comics Today fans still remember and love the British girls’ comic Misty for its bold visuals and narrative complexities. Yet its unique history has drawn little critical attention. Bridging this scholarly gap, Julia Round presents a comprehensive cultural history and detailed discussion of the comic, preserving both the inception and development of this important publication as well as its stories. Misty ran for 101 issues as a stand-alone publication between 1978 and 1980 and then four more years as part of Tammy. It was a hugely successful anthology comic containing one-shot and serialized stories of supernatural horror and fanta...
Secret Darlington explores the lesser-known history of the town of Darlington through a fascinating selection of stories, unusual facts and attractive photographs.
Now in its 35th edition, this is the most authoritative, detailed trade directory available for the United Kingdom and the Republic of Ireland.
'A gripping murder mystery and a vivid recreation of Paris under German Occupation.' ANDREW TAYLOR *WINNER OF THE HWA GOLD CROWN AWARD FOR BEST HISTORICAL FICTION* *SHORTLISTED FOR THE CWA HISTORICAL DAGGER AWARD* 'Terrific' SUNDAY TIMES, Best Books of the Month 'A thoughtful, haunting thriller' MICK HERRON 'Sharp and compelling' THE SUN * * * * * Paris, Friday 14th June 1940. The day the Nazis march into Paris, making headlines around the globe. Paris police detective Eddie Giral - a survivor of the last World War - watches helplessly on as his world changes forever. But there is something he still has control over. Finding whoever is responsible for the murder of four refugees. The unwante...
Now in its 37th edition, and compiled in association with the Publishers Association, this is the most authoritative, detailed trade directory available for the United Kingdom and the Republic of Ireland, listing over 900 book publishers. Comprehensive entries include, where available: - full contact details including addresses and websites - details of distribution and sales and marketing agents - key personnel - listing of main fields of activity - information on annual turnover, numbers of new titles and numbers of employees - ISBN prefixes including those for imprints and series - details of trade association membership - information on overseas representation - details of associated and parent companies. In addition to the detailed entries on publishers, the Directory offers in-depth coverage of the wider UK book trade and lists organizations associated with the book trade: packagers, authors' agents, trade and allied associations and services. The directory is also available to purchase as an online resource, for more information and a free preview please visit www.continuumbooks.com/directoryofpublishing