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Protein Phosphorylation in Parasites
This is the first book to collect and summarize in one publication the efforts to use kinases or phosphatases for drug development against parasite infections. The editors and contributors comprise the Who is Who in the field, and they are comprehensive in covering every aspect of the topic, from basic research findings to translational approaches in drug development The result will be welcomed by everyone in academia and industry participating in the global effort to finally combat the major diseases caused by eukaryotic parasites. This is volume one of a two-volume treatise, the second being exclusively dedicated to efforts to combat malaria using the same approach.
Progress in Cell Cycle Research
The "Progress in Cell Cycle Research" series is dedicated to serve as a collection of reviews on various aspects of the cell division cycle, with special emphasis on less studied aspects. We hope this series will continue to be helpful to students, graduates and researchers interested in the cell cycle area and related fields. We hope that reading of these chapters will constitute a "point of entry" into specific aspects of this vast and fast moving field of research. As PCCR4 is being printed several other books on the cell cycle have appeared (ref. 1-3) which should complement our series. This fourth volume of PCCR starts with a review on RAS pathways and how they impinge on the cell cycle...
Kinomics
Authored by the world's leading kinase experts, this is a comprehensive introduction to current knowledge and practice within this emerging field. Following an overview of the major players and pathways that define the kinome, the major part of this work is devoted to current strategies of kinome investigation and manipulation. As such, kinase engineering, peptide substrate engineering, co-substrate design and kinase inhibitor design are discussed in detail, and their potential applications in kinome analysis and kinome-based pharmacotherapy are shown. The result is a toolbox for every kinase researcher: By addressing and comparing current approaches to the study of kinase action, both novice and established researchers will benefit from the practical knowledge contained in this invaluable reference.
The Backstreets of Purgatory
Finn Garvie’s life is one spectacular mess. He spends most of his time fannying around a makeshift Glasgow studio, failing to paint his degree portfolio, while his girlfriend Lizzi treats him like one of her psychology patients, and his best friend Rob is convinced that the tattoos he designs are the height of artistic achievement. To top it all, Finn is worried that some stinking bastard is hanging around, spying on him, laughing at his cock-ups and eating his leftover curry. Fortunately, he has plenty of techniques to distract him – tackling the church hall renovations with the help of his alcoholic neighbour; pining after Kassia, the splendidly stroppy au-pair; and re-reading that boo...
Malaria Parasites
The completion of the Plasmodium falciparum genome sequence in late 2002 heralded a new era in malaria research. The search began in earnest for new drugs and vaccines to combat malaria, a disease which afflicts up to 500 million people worldwide and is responsible for the deaths of more than one million people each year. The new genomic data is aiding a greater understanding of the living parasite and its interaction with the insect vector and human host. In this book internationally renowned experts provide up-to-date reviews of the most important aspects of post-genomic malaria research. Topics covered include: the P. falciparum genome and model parasites, bioinformatics and genome databases, microsatellite analysis, analysis of chromosome structure, cell cycle to RNA polymerase I and II mediated gene expression, role of the nuclear genome, the parasite surface and cell biology, and much more. The book is essential to all researchers working in this highly topical field and is recommended reading for scientists in other areas of biology and medicine.
Combatting Deadly Diseases
The global emergency caused by HIV / AIDS, malaria and tuberculosis requires new approaches to confront these three major poverty-related diseases. ln response to this emergency, the European Commission provides a broad comprehensive approach in a wide range of policy areas, including trade, development and research. For research, the overall strategy is to develop new drugs, vaccines and other effective interventions through two mechanisms: (i) support of research projects of promising new candidates through pre-clinical and early human testing and (ii) establishment of a programme to support phases Il and III clinical trials in Africa through the EDCTP (European & Developping Clinical Trials Partnership). The sixth Framework Programme - FP6 (2002-2006) allocates a total of € 400 million to HIV / AIDS, malaria and tuberculosis with around 200 million for each of the interlinked components.
PAKs, RAC/CDC42 (p21)-activated Kinases
This book covers a variety of cutting-edge basic and clinical PAK research ranging from laboratory benches to hospital beds. The goal of this book is to inspire not only biomedical research scientists and university students, but also a variety of patients who suffer from PAK-dependent diseases and clinical doctors who try to cure or delay these PAK-dependent diseases.This book consists of 9 chapters which deal with different aspects of this kinase. These chapters are written by more than two dozen world-leading PAK experts. Each of these will provide updated biomedical information as well as future insight to a wide range of readers who are interested in this unique kinase and both its path...
