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Reproductive aging is a natural and universal process. Women frequently overestimate the age at which a significant decline in fertility occurs as well as overestimate the success of assisted reproductive technologies to circumvent age-related infertility. Yet there is much that modern medicine can do to improve conception rates in women who delay childbearing and to manage subsequent pregnancies. This book offers guidance on winning strategies for maximizing the live-birth rate and limiting the risk for women trying to conceive later in life. It is intended to assist in navigating this challenging journey and lead to peace of mind that women have been seen, heard, and treated as individuals in the process. Written by leading experts addressing medical options of applying advanced reproductive technologies, psychological, nutritional, lifestyle, systematic approaches to optimizing fertility care for the most challenging demographic of women in a practical, clinically orientated, and most importantly, positive way.
A critical review by prominent experts of both the cutting-edge of stem cell biology and the application of stem cells to endocrine diseases, including diabetes, infertility, and liver-associated metabolic disorders. The authors discuss current research to modify stem cells, develop an endocrine-like cell, and use adult bone marrow stem cells to treat autoimmune diseases, including endocrine-based autoimmune diseases. Topics of interest include a review of all stem cell subtypes and their characteristics, approaches to promoting endocrine development from stem cells, and evidence for endocrine cell function from stem cells. The authors also outline how best to develop preclinical studies that will determine the safety and efficacy of stem cell therapies for endocrine disorders.
This study guide is designed to help readers master and assimilate the material in Speroff, Glass and Kase's Clinical Gynecologic Endocrinology and Infertility (sixth edition). Chapters in the study guide parallel those in the textbook and present learning objectives, pre-test questions, and post-test questions. These questions should help you focus on key concepts and assess your knowledge and should assist in preparing for board or recertification exams. The answer to each question includes a reference to the appropriate page number in the textbook.
In this issue of Endocrinology and Metabolism Clinics of North America, guest editors Drs. Sherita Hill Golden and Rana Malek bring their considerable expertise to the topic of Health Equity in Endocrinology. Top experts discuss health disparities present in endocrinology and metabolism care, with the goal of achieving more equitable patient care in the areas of diabetes, women's reproduction, obesity, and more. - Contains 12 practice-oriented topics including peer support to enhance type 2 diabetes prevention among African American and Latino adults; global disparities in rickets/pediatric bone disease; racial and ethnic disparities in infertility treatment and assisted reproductive technol...
During the past five to ten years, a variety of tools has been developed in the disciplines of both gene engineering, and molecular and structural biology. Some of these advances have permitted scientists not only to identify and characterize genes, but also to target these genes by disruption, thus eliminating their function in living animals, and to det- mine the biological responses to altered gene products. This has particular significance in endocrine systems, in which feedback mechanisms between the hypothalamus, pi- itary, and end organs are critical in normal physiology. Interpretation of the physiological significance, or the site of action of specific molecules in this context, has...
A cutting-edge review of how derangements in the hormonal and growth factor mechanisms controlling normal mammary development lead to breast cancer. Drawing on the multidisciplinary expertise of leading authorities, the book highlights the roles of oncogenes and tumor suppressor genes, spelling out the importance of autocrine/paracrine loops (e.g., stromal epithelial interactions) in supporting breast cancer cell proliferation and the progression to hormone independence. The book's many prominent contributors also illuminate significant recent advances in the biochemistry and physiology of hormone receptors and review the state-of -the-art in the endocrine therapy of breast cancer. Endocrinology of Breast Cancer provides a unique integrated overview of the most significant basic and clinical developments concerning the hormonal aspects of breast cancer.
This title was first published in 2003. The fulfilment of health care rights in a world where resources are scarce is a prominent issue. In this volume, Frances H. Miller introduces studies on a wide variety of aspects of this important yet complex process.
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Internationally recognized experts, pioneers, and opinion makers in evidence-based medicine (EBM) provocatively recast endocrine policy and practice in the light of EBM philosophy and principles. The authors explain the past, present, and future of EBM; consider its practical implications for endocrinology; demonstrate what the "evidence base" is in EBM; and present illustrative case studies by practicing evidence-based clinicians. Highlights include essays on why cost-effective analyses are problematic, the contrast between clinical investigations and large randomized trials, the role of Cochrane reviews and meta-analyses, and the curriculum requirements for training evidence-based endocrinologists.