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Induction of immune tolerance: Addressing unmet medical need in immune mediated diseases and immune responses to biologics
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Tolerating Factor VIII: Novel Strategies to Prevent and Reverse Anti-FVIII Inhibitors
The article processing charges (APCs) for some articles in this collection were partly financed by the Henry M. Jackson Foundation for the Advancement of Military Medicine, Maryland, USA (HJF), with funds which were originally granted by Grifols S.A, Barcelona, Spain (Grifols). Neither HJF nor Grifols influenced the content of any article in this collection.
A Guide to Human Gene Therapy
1. Non-viral gene therapy / Sean M. Sullivan -- 2. Adenoviral vectors / Stuart A. Nicklin and Andrew H. Baker -- 3. Retroviral vectors and integration analysis / Cynthia C. Bartholomae [und weitere] -- 4. Lentiviral vectors / Janka Matrai, Marinee K.L. Chuah and Thierry VandenDriessche -- 5. Herpes simplex virus vectors / William F. Goins [und weitere] -- 6. Adeno-Associated Viral (AAV) vectors / Nicholas Muzyczka -- 7. Regulatory RNA in gene therapy / Alfred. S. Lewin -- 8. DNA integrating vectors (Transposon, Integrase) / Lauren E. Woodard and Michele P. Calos -- 9. Homologous recombination and targeted gene modification for gene therapy / Matthew Porteus -- 10. Gene switches for pre-clini...
The Immunological Barriers to Regenerative Medicine
This volume offers an analysis of the scale and nature of the immunological issues facing regenerative medicine, drawing on the expertise of laboratories around the world who have taken up the challenge of applying their expertise in immunology to the vagaries of stem cell biology. In Part I, we explore the extent to which the principles of allograft rejection, learned over several decades from our experiences of whole organ transplantation, apply within the unique context of cell replacement therapy. Part II discusses various innovative ways of addressing the issues of immunogenicity, while, in Part III, we focus exclusively on the induction of immunological tolerance through a variety of novel approaches. It is our hope that this systematic analysis of the current state of the field will galvanise efforts to solve an issue which has so far remained intractable.
Gene Delivery Systems
This unique volume in our Drugs and Pharmaceutical Sciences series covers the development of gene therapy today, the technology involved, clinical applications of siRNA, non-viral vector-based mRNA delivery using nanotechnology, and RNA based vaccines for treating the infectious diseases. It also presents the current application of the CRISPR/Cas9 gene-editing technique which has revolutionized genome editing and which was awarded the 2020 Nobel Prize in Chemistry. Several new drug delivery systems are explored for the applications of gene therapy. These are found to be useful in treating chronic illnesses, including cancer and infectious diseases. Key Features: Overview of the development of gene therapy Provides the most up to date information on the development of gene therapy, from the technology involved to gene correction and genome editing Presents CRISPR gene therapy recent trends and applications Discusses siRNA, mRNA, and DNA plasmids
Memoirs of My Last Year of COVID-19
It is the author’s final documentary book on COVID-19, number Eight as it ended! A total series of Eight books covering, from author’s perspective, the entire journey, since the very beginning of SARS-COV-2 Late 2019. Memoirs are written as events had occurred and interpreted with the author’s personal views and experiences. The book contains much of the author’s philosophically and spiritual meditations as well. The last year of COVID Pandemic is an interesting transition to what is known as the “New Norm”. Many stories of daily events are shared, not only as a frontline Physician, Anesthesiologist and Neurosurgeon but also as a Christian believer with deep spiritual reflections...
Molecular Mechanisms of Dendritic Cell-Mediated Immune Tolerance and Autoimmunity
Dendritic cells (DCs) play a critical role in immune system, as they are necessary both for innate and adaptive immunity. According to their function, dendritic cells can be classified in immune tolerogenic or inflammatory DCs. DCs have been shown to regulate T cell-mediated immune responses and lead to immune tolerance and autoimmunity. For example, immune-tolerogenic DCs facilitate the development of regulatory T cells and inhibit T helper 17-mediated autoimmunity in mice with experimental autoimmune encephalomyelitis. Moreover, inflammatory DCs activate CD8+ and CD4+ T cells and elicit T cell-mediated inflammatory immune responses in vivo. However, the molecular and cellular mechanisms underlying DC-mediated immune tolerance and autoimmunity are still obscure.
AAV Gene Therapy: Immunology and Immunotherapeutics
Dr. Gao is the co-founder of Voyager Therapeutics, Adrenas Therapeutics and Aspa Therapeutics. His research laboratory receives financial support from sponsored research agreements with various companies including Merck and LuYe Pharma. The other Topic Editors declare no conflict of interest with regards to the Research Topic theme
HEALTH & SCIENCE 2023-I
THE EFFECT OF ARTIFICIAL INTELLIGENCE ON HEALTH TODAY Kubilay Ozgur OZTUTUNCU, Ahmet Necati SANLI, Samet YIGMAN APPLICATIONS AND HURDLES OF GENOME EDITING IN CLINICS Seher YAYLACI AN OVERVIEW OF THE BIOGENESIS, FUNCTIONS AND POTENTIAL ROLES OF CIRCULAR RNAS Ilknur ÇINAR AYAN POLYPHARMACY AND CARDIO-ONCOLOGY: TIME TO PONDER THE ROLE OF CYP450 MRNA Andleeb SHAHZADI BIOCHEMICAL TUMOR MARKERS Seyhan TURK GUT MICROBIOTA AND SCHIZOPHRENIA: EFFECTS OF CLINICAL TREATMENTS AND PROBIOTICS ON GUT MICROBIOTA Irem ALTUNTAŞ, Hatice TURAN PESTEL, Hamideh HAMMAMCHI OSTEITIS IN CHRONIC RHINOSINUSITIS Atılay YAYLACI DO STABILIZATION SPLINT AND BOTOX USED IN BRUXISM TREATMENT CONTRIBUTE TO THE CHANGE IN OCC...
Lentivirus Gene Engineering Protocols
Cell gene engineering is emerging as a field with outstanding impact, not only in medicine/biology, but also, and perhaps most importantly, in agriculture and in all those food sciences involved in the fight against world hunger. Lentivirus vector-based technologies represent the last frontier in the development of powerful and reliable methods for both in vitro and in vivo gene transfer in eukaryotic animal cells. Although the design of lentivirus vectors is closely reminiscent of those already successfully applied to the construction of oncoretroviral vectors, some unique features, e.g., the ef- ciency in transducing both postmitotic and stem cells, render the use of lentivirus vectors inv...
