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DNA Topoisomerases in Cancer Therapy
In the mid 80's type I and II enzymes were found to be the intracellular targets of a number of efficacious anticancer drugs such as doxorubicin, mitoxantrone, etoposide and camptothecin as a result of a continued efforts of many investigators, especially Leroy Liu and his collaborators at Johns Hopkins University. Readers will find a series of chapters written by researchers actively engaged in the expanding field of topoisomerase and their inhibitors. The series of chapters cover review articles on pharmacology and the molecular mechanism of topoisomerase I- and II-targeting anticancer drugs in mammals and in the yeast Saccharomyces cerevisiae, which has proved to be a superb model organism for studies of anticancer drugs. This volume compiles up-to-date information on the topoisomerase-targeting compounds in clinical and preclinical development as a useful and important reference book for students and researchers in the field of pharmacology, toxicology, oncology and molecular biology.
Advances in DNA Sequence-specific Agents
In this volume the entire focus is devoted to the macromolecule target specificity of DNA interactive developmental therapeutic agents of current interest. A brief introduction to DNA interactive anticancer agents is included for readers who may benefit from an overview surrounding the developments that have contributed to our general understanding of this field. The following nine chapters have been carefully chosen so that they describe topics which are at the forefront of development in DNA-targeted cancer chemotherapy. Issues that have been addressed include the mechanisms of selective DNA topoisomerase I and II poisoning by antitumor agents (Chapters 1 and 2), sequence-specific recognit...
Power in Language, Culture, Literature and Education
In one of the contributions to this edited volume an interviewee argues that "English is power". For researchers in the field of English Studies this raises the questions of where the power of English resides and which types and practices of power are implied in the uses of English. Linguists, scholars of literature and culture, and language educators address aspects of these questions in a wide range of contributions. The book shows that the power of English can oscillate between empowerment and subjection, on the one hand enabling humans to develop manifold capabilities and on the other constraining their scope of action and reflection. In this edited volume, a case is made for self-critical English Studies to be dialogic, empowering and power-critical in approach.
Forced Migration Research
In 2018, the United Nations High Commissioner for Refugees estimated 70.8 million people could be considered forced migrants, which is nearly double their estimation just one decade ago. This includes internally displaced persons, refugees, asylum seekers, and stateless people. This drastic increase in forced migrants exacerbates the already urgent need for a systematic policy-related review of the available data and analyses on forced migration and refugee movements. To explore the causes and impacts of forced migration and population displacement, the National Academies convened a two-day workshop on May 21-22, 2019. The workshop discussed new approaches in social demographic theory, metho...
Handbook on the Governance and Politics of Water Resources
This cutting-edge Handbook provides a global perspective on the current issues affecting water politics and governance. Focusing in particular on the policy-making process and the power dynamics that it involves, it showcases the emerging diversity of objectives, instruments and governance approaches in the field of water resources.
Use of Economic Instruments in Water Policy
This book assesses both the effectiveness and efficiency of implemented Economic Policy Instruments (EPIs) in order to achieve water policy goals and identifies the preconditions under which they outperform alternative (e.g. regulatory) policy instruments and/or can complement them as part of complex policy mixes. The development of a consolidated assessment framework helps clarify (and where possible, quantify) the effectiveness of each EPI on the basis of different criteria. Outcome-oriented criteria describe how the EPIs perform. They include intended and unintended economic and environmental outcomes and the distribution of benefits and costs among the affected parties. These steps consi...
The Civil Power of the News
This landmark book is concerned with the civil power of the news. This power can be seen in the ways the news engages with public sentiment through a focus on three invariant civil concerns: identity, legitimacy and risk. The book analyses how news stories engage with these concerns to make civil and anti-civil judgements, which influence public sentiment and determine the boundaries we place and maintain around the society we live in. Through historical and contemporary examples of this boundary shaping and maintenance, The Civil Power of the News presents a bold and original account of the architecture of news, the influence it has on our conceptions of civility, and, ultimately, the power it wields.
Toward a Better World
What has nursing to do with the good society--or indeed, with the earth's health? Toward a Better World argues that promoting equality, peace and respect, providing assistance and safety, and safeguarding the health of our planet are among the obligations of the nursing profession. The book explores how, by fulfilling these obligations on a global scale, nurses have the power to bring about a better world.
Implementing the Water-Energy-Food-Ecosystems Nexus and Achieving the Sustainable Development Goals
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