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ESMO Handbook on Principles of Translational Research
Using state-of-the-art and evidence-based literature references and reviews, the authors present an overview of translational research that is both reliable and easily understood. The book begins with principles of normal cell biology and normal immunology. It examines tumor biology and basic tumor immunology. It then discusses limitless replicativ
ESMO Handbook of Cancer Prevention
This handbook summarizes the fast-moving world of research into prevention of cancer. An international selection of experts here present the points of most relevance for oncologists and those involved professionally with prevention and screening programmes.
Cancer Immunology
This book explains the immunology of organ-specific malignancies and discusses novel immunotherapy strategies for their treatment. Since the first, very successful edition of the book was published in 2015, a number of entirely new chapters have been included. The range of cancers considered has accordingly been extended, with coverage of the latest immunotherapy approaches for cancers in different organs. In addition, the original chapters have been updated to document the latest advances in immunotherapy for pediatric solid tumors, hematologic malignancies, gastrointestinal tumors, bone tumors, central nervous tumors, lung cancer, genitourinary tract tumors, and breast cancer, among others. The book is published as part of the three-volume Springer series Cancer Immunology, which aims to provide an up-to-date, clinically relevant review of cancer immunology and immunotherapy. Other volumes in the series address the translational medicine context and bench to bedside immunotherapy. Cancer Immunology: Cancer Immunotherapy for Organ-Specific Tumors will be of special value to clinical immunologists, hematologists, and oncologists.
Advances in Cancer Research
The Advances in Cancer Research series provides invaluable information on the exciting and fast-moving field of cancer research. This volume presents outstanding and original reviews on a variety of topics including NY-ESO-1: review of an immunogenic tumor antigen; Order, disorder, death: lessons from a superorganism; Control of differentiation in progression of epithelial tumors; Cancer vaccines: preclinical studies and novel strategies; Clinical results of vaccine therapy for cancer: learning from history for improving the future; Immunodominance and immunodomination: critical factors in developing effective CD8+ T-cell based cancer vaccines; NK cell receptors as tools in cancer immunotherapy; Innate immune recognition and suppression of tumors; Inhibitors of the HSP90 molecular chaperone: current status.
NK Cells and Other Natural Effector Cells
NK Cells and Other Natural Effector Cells reviews the state of knowledge on NK cells and other natural effector mechanisms. The coverage of immune effector systems ranges from basic studies on their nature, regulation, and mechanisms of action to important practical issues such as their role in host resistance, their modulation by therapeutic intervention, and alterations of their activity in disease. The book is organized into 12 parts. Parts I and II examine the characteristics of NK cells and other natural effector cells, respectively. Part III focuses on the cell lineage of NK and related effector cells, providing evidence for or against T cell lineage, for or against macrophage lineage,...
Multiple Myeloma and Related Disorders
During the past decade there has been an enormous increase in knowledge of multiple myeloma and related disorders, reflected in the publication of more than 5000 articles on the subject in scientific journals. Much of this has come about as new technologies have made it possible to refine studies on chromosomes and genes and to gain information about gene expression. It is therefore highly appropriate that this new comprehensive reference should appear at this time. The book covers the whole field of multiple myeloma, and also related diseases such as Waldemstr&öm&’s macroglobulinaemia, and incorporates both the basic science underlying the diseases and their clinical management. Each chapter has been written to &’stand alone&’, allowing the reader to dip into a particular subject and find information quickly without the need to browse through multiple chapters. In addition to the developments described above, all of which are considered here, many other approaches to targeted therapy are reviewed.
Handbook of Anticancer Pharmacokinetics and Pharmacodynamics
Leading investigators synthesize the entire laboratory and clinical process of developing anticancer drugs to create a single indispensable reference that covers all the steps from the identification of cancer-specific targets to phase III clinical trials. These expert authors provide their best guidance on a wide variety of issues, including clinical trial design, preclinical screening, and the development and validation of bioanalytic methods. The chapters on identifying agents to test in phase III trials and on trial design for the approval of new anticancer agents offer a unique roadmap for moving an agent to NDA submission.
T Lymphocytes
This volume contains the proceedings of the NATO Advanced Study Institute held in Porto Conte (Alghero), Sardinia, September 15-27, 1991. The A. S. 1. was attended by 86 graduate and postgraduate students from 18 different countries, and was hosted by the newly founded International Laboratory of Molecular Genetics of Porto Conte, directed by Prof. Marcello Siniscalco. The A. S. I. was funded by NATO Scientific Affairs Division, the International Union of Immunological Societies, the European Community (Directorate General for Science, Research and Development), the Italian Research Council, and the San Raffaele Institute of Milano. In addition, a number of students who reside in the U. S. received travel funds from the U. S. National Science Foundation, and the Turkish National Fund provided financial assistance to several students from Turkey. When we decided to organize a course on T lymphocytes, our concern was to reach a balance between the teaching of both the hard core principles and the latest experimental findings of cellular immunology, and the recently expanded interfaces with the not-yet known: hypotheses, speCUlations, new projections to be born from the discussions.
Therapeutic Monoclonal Antibodies
A review of therapeutic antibodies which have commercial potential. It discusses PCR cloning of Igs, immortalization by gene transfer, scale up production, infectious diseases, viruses, bacteria, parisites, inflammation/immunology, blood grouping, cells, cytokines, tumours and MDR.
