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Nonlinear Analysis of Physiological Data
This book is more than a standard proceedings volume, although it is an almost direct result of the workshop on "Nonlinear Analysis of Physiologi cal Time Series" held in Freital near Dresden, Germany, in October 1995. The idea of the meeting was, as for previous meetings devoted to related topics, such as the conference on dynamical diseases held near Montreal in February 1994 (see CHAOS Vol. 5(1), 1995), to bring together experts on the techniques of nonlinear analysis and the theory of chaos and applicants from the most fascinating field where such methods could potentially be useful: the life sciences. The former group consisted mainly of physicists and mathe maticians, the latter was re...
The Molecular Mechanisms of Regulatory T cell Immunosuppression
Ever since Regulatory T cells (T-Regs) were first defined as peripheral CD4+ T cells that express the interleukin-2 (IL-2) receptor alpha chain (IL-2Ra), there have been intensive efforts to determine the molecular mechanisms whereby this minor subset of CD4+ T cells (~ 5-10%) nonspecifically suppresses all potential effector T cells, whether reactive to self or non-self antigens. Multiple possible molecular mechanisms have been implicated, including the scavenging of IL-2 via the expression of high densities of IL-2Rs, the inhibition of antigen presentation via CTLA-4 molecules leading to decreased IL-2 production, the activation of intracellular cAMP thereby suppressing both IL-2 productio...
Towards Tokyo 2020: What Will Contribute to Optimal Olympic Athlete Performance?
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Ontogeny and Phylogeny of Brain Barrier Mechanisms
The brain functions within an internal environment that is determined and controlled by morphological structures and cellular mechanisms present at interfaces between the brain and the rest of the body. In vertebrates these interfaces are across cerebral blood vessels (blood-brain barrier) choroid plexuses (blood-cerebrospinal fluid barrier) and pia-arachnoid. There is a CSF-brain barrier in the neuroepithelium lining the ventricular system that is only present in embryos. There is now substantial evidence that many brain barrier mechanisms develop early and that in some cases they are functionally more active and even more specialized compared to adult barriers. Therefore barriers in develo...
Information- and Communication Theory in Molecular Biology
This edited monograph presents the collected interdisciplinary research results of the priority program “Information- and Communication Theory in Molecular Biology (InKoMBio, SPP 1395)”, funded by the German Research Foundation DFG, 2010 until 2016. The topical spectrum is very broad and comprises, but is not limited to, aspects such as microRNA as part of cell communication, information flow in mammalian signal transduction pathway, cell-cell communication, semiotic structures in biological systems, as well as application of methods from information theory in protein interaction analysis. The target audience primarily comprises research experts in the field of biological signal processing, but the book is also beneficial for graduate students alike.
Complexity, Chaos, and Biological Evolution
From time to time, perhaps a few times each century, a revolution occurs that questions some of our basic beliefs and sweeps across otherwise well guarded disciplinary boundaries. These are the periods when science is fun, when new paradigms have to be formulated, and when young scientists can do serious work without first having to acquire all the knowledge of their teachers. The emergence of nonlinear science appears to be one such revolution. In a surprising manner, this new science has disclosed a number of misconceptions in our traditional understanding of determinism. In particular, it has been shown that the notion of predictability, according to which the trajectory of a system can b...
Data Management of Protein Interaction Networks
Current PPI databases do not offer sophisticated querying interfaces and especially do not integrate existing information about proteins. Current algorithms for PIN analysis use only topological information, while emerging approaches attempt to exploit the biological knowledge related to proteins and kinds of interaction, e.g. protein function, localization, structure, described in Gene Ontology or PDB. The book discusses technologies, standards and databases for, respectively, generating, representing and storing PPI data. It also describes main algorithms and tools for the analysis, comparison and knowledge extraction from PINs. Moreover, some case studies and applications of PINs are also discussed.
Modelling the Dynamics of Biological Systems
The development of a proper description of the living world today stands as one of the most significant challenges to physics. A variety of new experimental techniques in molecular biology, microbiol ogy, physiology and other fields of biological research constantly expand our knowledge and enable us to make increasingly more detailed functional and structural descriptions. Over the past decades, the amount and complexity of available information have multiplied dramatically, while at the same time our basic understanding of the nature of regulation, behavior, morphogenesis and evolution in the living world has made only modest progress. A key obstacle is clearly the proper handling of the a...
Music in Human Experience
Music plays an integral role in many facets of human life, from the biological and social to the spiritual and political. This book brings together interdisciplinary and cross-cultural studies on the functions, purposes, and meanings of music in human experience.
Handbook of Proteomic Methods
A compendium of thirty-four powerful techniques for identifying and analyzing the diversity of proteins expressed in cells. Thee readily reproducible proteomic methods range from general to specific techniques, and include methods for data analysis, posttranslational modification, and its variants and isoforms. Additional methods demonstrate the application of proteomics to the discovery of serological tumor markers, to identifying the determinants of sensitivity to antitumor drugs, and to specialized fields, such as endocrinology, plant biology, nephrology, and urology.
