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Ontogeny and Phylogeny of Brain Barrier Mechanisms
The brain functions within an internal environment that is determined and controlled by morphological structures and cellular mechanisms present at interfaces between the brain and the rest of the body. In vertebrates these interfaces are across cerebral blood vessels (blood-brain barrier) choroid plexuses (blood-cerebrospinal fluid barrier) and pia-arachnoid. There is a CSF-brain barrier in the neuroepithelium lining the ventricular system that is only present in embryos. There is now substantial evidence that many brain barrier mechanisms develop early and that in some cases they are functionally more active and even more specialized compared to adult barriers. Therefore barriers in develo...
10 Years of Neuropharmacology
I am delighted to write a preface for this Celebratory eBook published in the Specialty Section Neuropharmacology, within the journal Frontiers in Pharmacology. The eBook delivers a compendium of high impact papers published previously in the journal over the last ten years; at the time of writing this collection of 20 papers has been viewed 700k times with over 75k downloads. Clearly this Section is delivering a useful resource to the scientific and medical research community! The scope of the Specialty Section Neuropharmacology is deliberately broad. We encourage submission of high quality and impactful papers in the field of neuropharmacology along the full length of the translational esc...
Beyond the borders: The gates and fences of Neuroimmune interaction
Neuroimmunology is a rapidly growing emerging field at which two old sciences have converged to integrate two different types of responses into a single coherent response involving the coordinated action of both systems, neural and immune. During long time it was thought that both systems worked separately and in divergent pathways. The brain was considered an immunoprivileged site and the immune organs were deemed as independent of any neural influence and also of nervous innervation. Time has gone and has proven that the borders between both systems were merely artificial. Since the beginning of Neuroimmunology in the 1980s much work has been done to elucidate the gates and fences in neuro...
Neuro-Immune Interactions in Inflammation and Autoimmunity
The nervous system plays an important role in the regulation of immunity and inflammation. On the other hand unbalanced immune responses in inflammatory and autoimmune conditions may have a deleterious impact on neuronal integrity and brain function. Recent studies have characterized neural pathways communicating peripheral inflammatory signals to the CNS, and brain- and spinal cord-derived circuitries controlling various innate and adaptive immune responses and inflammation. A prototypical neural reflex circuit that regulates immunity and inflammation is the vagus nerve-based “inflammatory reflex”. Ongoing research has revealed cellular and molecular mechanisms underlying these neural c...
The Autobiography of a Transgender Scientist
A POIGNANT LGBT MEMOIR: A leading trans neuroscientist recounts his gender transition, his groundbreaking scientific work, and his advocacy for gender equality in STEM. “A portrait of a singular personality that was shaped by his status as an outsider.” —Science Ben Barres was known for his groundbreaking scientific work and advocacy for gender equality in science. In this autobiography, completed shortly before his death from pancreatic cancer in December 2017, Barres (born in 1954) describes a life full of remarkable accomplishments—from his childhood as a precocious math and science whiz to his experiences as a female student at MIT in the 1970s to his gender confusion and later t...
Neuroimmune System
The book explores the intricate connections between the nervous and immune systems in the context of neurodegenerative disorders, offering a comprehensive overview of the bidirectional communication between these systems and their implications for disease progression and therapeutic interventions. The book aims to understand the recent developments in the field of neuroimmune communication. Key Features: In-depth analysis of immunological biomarkers and therapeutic targets for neurodegenerative disorders. Exploration of the role of glial cells in neuroimmune interactions and their dual nature in disease pathology. Examination of short- and long-range interactions between the central nervous ...
Brain Fables
With no biological boundaries between neurodegenerative diseases as defined today, Brain Fables offers a blueprint for precision medicine.
Molecular Links Between Mitochondrial Damage and Parkinson's Disease and Related Disorders
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Transforming Higher Education Through Digitalization
Higher education is dynamic, constantly adapting to meet the requirements of students and industry. Transforming Higher Education Through Digitalization: Insights, Tools, and Techniques provides insights from experienced academicians on the digitalization of education and its appropriateness for enhancing the quality of teaching in institutions of higher education. The book also provides insights on technologies used in digital education, the competencies and skills required by teachers and students, managing quality of education through online modes, MOOCs (Massive, Open, Online Courses), and methods to support teachers and instructors in online education. The book also enables teachers and instructors to help students develop the knowledge and skills they need in a digital age and enable them to build collaborative learning that will bring them success. Written for educators, students, and policy makers of higher education, this book demonstrates how to transform traditional education to digital education and to continue their activities without the requirement of students and teachers meeting each other on campus.
