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Src-like Adaptor Protein: A Molecule that Regulates TCR/CD3 Expression by Adapting the E3 Ubiquitin Ligasec-Cbl to the TCR/CD3 Complex
Src-Like Adaptor Protein (SLAP) downregulates expression of the T cell receptor (TCR)/CD3 complex during a specific stage of thymocyte development when the TCR repertoire is selected. Consequently, SLAP -/- thymocytes display alterations in thymocyte development. Interestingly, mice deficient in either SLAP or c-Cb1 have very similar thymic phenotypes. We have studied the mechanism of TCR/CD3 downregulation by SLAP and c-Cb1. Using mice deficient for SLAP and/or c-Cb1 we demonstrate that thymocytes deficient in SLAP and/or c-Cb1 have increased TCRZeta chain expression due to a defect in TCRZeta degradation. Failure to degrade TCRZeta leads to an increased pool of fully assembled TCR/CD3 comp...
Computer-Aided Drug Design
This book provides up-to-date information on bioinformatics tools for the discovery and development of new drug molecules. It discusses a range of computational applications, including three-dimensional modeling of protein structures, protein-ligand docking, and molecular dynamics simulation of protein-ligand complexes for identifying desirable drug candidates. It also explores computational approaches for identifying potential drug targets and for pharmacophore modeling. Moreover, it presents structure- and ligand-based drug design tools to optimize known drugs and guide the design of new molecules. The book also describes methods for identifying small-molecule binding pockets in proteins, and summarizes the databases used to explore the essential properties of drugs, drug-like small molecules and their targets. In addition, the book highlights various tools to predict the absorption, distribution, metabolism, excretion (ADME) and toxicity (T) of potential drug candidates. Lastly, it reviews in silico tools that can facilitate vaccine design and discusses their limitations.
Pursuit-Evasion Differential Games
Twenty papers are devoted to the treatment of a wide spectrum of problems in the theory and applications of dynamic games with the emphasis on pursuit-evasion differential games. The problem of capturability is thoroughly investigated, also the problem of noise-corrupted (state) measurements. Attention is given to aerial combat problems and their attendant modelling issues, such as variable speed of the combatants, the three-dimensionality of physical space, and the combat problem, i.e. problems related to 'role determination'.
Cooperative Networking
This book focuses on the latest trends and research results in Cooperative Networking This book discusses the issues involved in cooperative networking, namely, bottleneck resource management, resource utilization, servers and content, security, and so on. In addition, the authors address instances of cooperation in nature which actively encourage the development of cooperation in telecommunication networks. Following an introduction to the fundamentals and issues surrounding cooperative networking, the book addresses models of cooperation, inspirations of successful cooperation from nature and society, cooperation in networking (for e.g. Peer-to-Peer, wireless ad-hoc and sensor, client-serv...
Low Complexity MIMO Detection
Low Complexity MIMO Detection introduces the principle of MIMO systems and signal detection via MIMO channels. This book systematically introduces the symbol detection in MIMO systems. Includes the fundamental knowledge of MIMO detection and recent research outcomes for low complexity MIMO detection.
