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Glial cells are commonly viewed as subordinate players to the functional requirements of neighbouring neurons - in normal as well as pathological conditions. These neuron-glial interactions are crucial for the development, maintenance, plasticity and repair of the nervous system. They are also dependent upon and/or influenced by interactions between glial cells themselves.
Vertebrate sensory neurons occupy a unique place in the nervous system, conveying information from the periphery to the CNS. While sensory physiologists have long recognized differences in response properties among cells in dorsal root and cranial ganglia, the full extent of heterogeneity among these neurons has only recently become apparent. Phenotypic diversity is the underlying theme of this unique work, which summarizes our current understanding of the individual characteristics and development of sensory neurons. The chapters are arranged in three cohesive sections. The first describes heterogeneity in the function, biochemical make-up, ion channels, membrane properties, and central pro...
Spinal cord injuries typically strike young, previously healthy persons, and leaves the individual with a severe, life-lasting impairment affecting all organ systems. Without adequate management, the risk of severe morbidity and mortality is very high. In contrast state-of-the-art management makes it possible for most persons with SCI to lead long, fulfilling, and autonomous lives despite neurological impairment. This book covers all medical and surgical aspects of modern SCI management from the scene of the accident through rehabilitation to the life-long follow up.
In keeping with the broad objectives set for the serial publication of Advances in Structural Biology, Volume 6 contains exhaustive articles from experts in diverse areas of biomedical research. The common thread among the various articles is their relevance to the applications of cell biology to human health.
This book builds a novel bridge from molecular research to clinical therapy. This approach reveals the functional features of neurons and glia in the particular context of vulnerability and self-protection, intracellular properties and extracellular matrix. Arising from this platform, this volume unfolds the molecular and systemic processes underlying migration disorders, axonal injury, repair and regeneration.
Advances in Developmental Biology was launched as a series by JAI Press in 1992 with the appearance of Volume 1. This series is inextricably linked to the companion series, Advances in Developmental Biochemistry, that was launched at the same time. As stated in the Preface to Volume 1: "Together the two series will provide annual reviews of research topics in developmental biology/biochemistry, written from the perspectives of leading investigators in these fields. It is intended that each review draw heavily form the author's own research contributions and perspective. Thus, the presentations are not necessarily encyclopedic in coverage, nor do they necessarily reflect all opposing views of the subject." Volume 2 of the series follows these same guidelines.
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