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Bad Bugs in the XXIst Century: Resistance Mediated by Multi-Drug Efflux Pumps in Gram-Negative Bacteria
The discovery of antibiotics represented a key milestone in the history of medicine. However, with the rise of these life-saving drugs came the awareness that bacteria deploy defence mechanisms to resist these antibiotics, and they are good at it. Today, we appear at a crossroads between discovery of new potent drugs and omni-resistant superbugs. Moreover, the misuse of antibiotics in different industries has increased the rate of resistance development by providing permanent selective pressure and, subsequently, enrichment of multidrug resistant pathogens. As a result, antimicrobial resistance has now become an urgent threat to public health worldwide (http://www.who.int/drugresistance/docu...
Chance in Evolution
This illuminating volume explores the effects of chance on evolution, covering diverse perspectives from scientists, philosophers, and historians. The evolution of species, from single-celled organisms to multicellular animals and plants, is the result of a long and highly chancy history. But how profoundly has chance shaped life on earth? And what, precisely, do we mean by chance? Bringing together biologists, philosophers of science, and historians of science, Chance in Evolution is the first book to untangle the far-reaching effects of chance, contingency, and randomness on the evolution of life. The book begins by placing chance in historical context, starting with the ancients and movin...
Membrane Transport Mechanism
This book provides a molecular view of membrane transport by means of numerous biochemical and biophysical techniques. The rapidly growing numbers of atomic structures of transporters in different conformations and the constant progress in bioinformatics have recently added deeper insights. The unifying mechanism of energized solute transport across membranes is assumed to consist of the conformational cycling of a carrier protein to provide access to substrate binding sites from either side of a cellular membrane. Due to the central role of active membrane transport there is considerable interest in deciphering the principles of one of the most fundamental processes in nature: the alternati...
Bacterial Mechanisms of Antibiotic Resistance: A Structural Perspective
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Current Ornithology Volume 17
Current Ornithology publishes authoritative, up-to-date, scholarly reviews of topics selected from the full range of current research in avian biology. Topics cover the spectrum from the molecular level of organization to population biology and community ecology. The series seeks especially to review (1) fields in which an abundant recent literature will benefit from synthesis and organization, or (2) newly emerging fields that are gaining recognition as the result of recent discoveries or shifts in perspective, or (3) fields in which students of vertebrates may benefit from comparisons of birds with other classes. All chapters are invited, and authors are chosen for their leadership in the subjects under review.
Reading the Book of Nature in the Dutch Golden Age, 1575-1715
The conviction that Nature was God's second revelation played a crucial role in early modern Dutch culture. This book offers a fascinating account on how Dutch intellectuals contemplated, investigated, represented and collected natural objects, and how the notion of the 'Book of Nature' was transformed.
Health Promotion Theory
This fully updated edition will help students and professionals develop an understanding of the core health promotion theories.
