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This expanded third edition provides an introduction to the conduct of clinical research as well as more comprehensive and expansive content about the infrastructure necessary for a successful clinical research organization or enterprise. With authors who are experts in clinical research in both the public and private sectors, this publication provides essential information to clinical investigators who wish to develop and conduct well designed patient-based research protocols that comply with rigorous study design, ethical, and regulatory requirements.
The second edition of this innovative work again provides a unique perspective on the clinical discovery process by providing input from experts within the NIH on the principles and practice of clinical research. Molecular medicine, genomics, and proteomics have opened vast opportunities for translation of basic science observations to the bedside through clinical research. As an introductory reference it gives clinical investigators in all fields an awareness of the tools required to ensure research protocols are well designed and comply with the rigorous regulatory requirements necessary to maximize the safety of research subjects. Complete with sections on the history of clinical research...
"A spirited spin through some of the most intriguing factoids in show business, offering up an unconventional history of the theatre in all its idosyncratic glory. From the cantakerous retorts of George Abbott to the literally show-stopping antics of Katherine Hepburn, you'll learn about the adventures and star turns of some of Broadway's biggest personalities, and discover little-known tidbits about beloved plays and musicals."--
Happiness is an everyday term in our lives, and most of us strive to be happy. But defining happiness can be difficult. In this Very Short Introduction, Dan Haybron considers the true nature of happiness. By examining what it is, assessing its importance in our lives, and how we can (and should) pursue it, he considers the current thinking on happiness, from psychology to philosophy. Illustrating the diverse routes to happiness, Haybron reflects on contemporary ideas about the pursuit of a good life and considers the influence of social context on our satisfaction and well-being. ABOUT THE SERIES: The Very Short Introductions series from Oxford University Press contains hundreds of titles in almost every subject area. These pocket-sized books are the perfect way to get ahead in a new subject quickly. Our expert authors combine facts, analysis, perspective, new ideas, and enthusiasm to make interesting and challenging topics highly readable.
New York magazine was born in 1968 after a run as an insert of the New York Herald Tribune and quickly made a place for itself as the trusted resource for readers across the country. With award-winning writing and photography covering everything from politics and food to theater and fashion, the magazine's consistent mission has been to reflect back to its audience the energy and excitement of the city itself, while celebrating New York as both a place and an idea.
The analysis of gene expression profile data from DNA micorarray studies are discussed in this book. It provides a review of available methods and presents it in a manner that is intelligible to biologists. It offers an understanding of the design and analysis of experiments utilizing microarrays to benefit scientists. It includes an Appendix tutorial on the use of BRB-ArrayTools and step by step analyses of several major datasets using this software which is available from the National Cancer Institute.
In this critical biography, Susan Lee Johnson braids together lives over time and space, telling tales of two white women who, in the 1960s, wrote books about the fabled frontiersman Christopher "Kit" Carson: Quantrille McClung, a Denver librarian who compiled the Carson-Bent-Boggs Genealogy, and Kansas-born but Washington, D.C.- and Chicago-based Bernice Blackwelder, a singer on stage and radio, a CIA employee, and the author of Great Westerner: The Story of Kit Carson. In the 1970s, as once-celebrated figures like Carson were falling headlong from grace, these two amateur historians kept weaving stories of western white men, including those who married American Indian and Spanish Mexican w...