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Written by internationally recognized experts, Pulmonary Hypertension bridges the gap between pulmonology and cardiology to provide clinicians in both disciplines with knowledge of the signs, symptoms, diagnosis, and pharmacologic and surgical treatments for pulmonary hypertension (PH). Through the use of clinical trials, this ground-breaking text supplies a comprehensive review of both the primary and secondary clinical and investigative aspects of this condition. Discussing controversies and concepts in PH diagnosis and management, this guide explores: classification and epidemiology, pathology, pathogenesis, genetics, and diagnosis of PH causes of the condition, such as idiopathic pulmonary arterial hypertension (IPAH) PAH-complicating connective tissue diseases (CTD), congenital heart diseases, human immunodeficiency virus (HIV), and other disorders the mechanisms, toxicities, and efficacy of therapeutic agents the role of combination therapies, novel agents, and future directions PH in specific patient populations such as pregnant and critically-ill patients in the ICU
This volume focuses on current evidence-based pharmacological treatments of various forms of pulmonary hypertension and provides a comprehensive review of the latest developments in this area. The first part of the book covers the definition, classification, pathophysiology, pathology, biomarkers and animal models of the disease, thus laying the conceptual basis for what follows. The middle section provides an overview of the established therapies, such as calcium channel blockers, prostanoids, endothelin receptor antagonists, phosphodiesterase-5 inhibitors and inhaled nitric oxide. The last section explores novel pathways and emerging therapeutic approaches including soluble guanylate cyclase stimulators, Rho-kinase inhibitors, inhibitors of serotonin receptors and transporters, peptide growth factors, vasoactive peptides, modulators of redox equilibrium and cyclic nucleotide homeostasis, as well as immunosuppressive and anti-proliferative agents. Particular attention is given to the clinical applications of these experimental therapies, that are on the horizon. The book thus spans the continuum from basic science to clinical applications.
The European Respiratory Society (ERS) Handbook of Respiratory Medicine, now in its third edition, is a concise, compact and easy-to-read guide to each of the key areas in respiratory medicine. Its 20 sections, written by clinicians and researchers at the forefront of the field, explain the structure and function of the respiratory system, its disorders and how to treat them. The Handbook is a must-have for anyone who intends to remain up to date in the field, and to have within arm's reach a reference that covers everything from the basics to the latest developments in respiratory medicine.
Authoritative, comprehensive and definitive, Pulmonary Circulation builds on the success of its previous two editions by providing practising respiratory physicians with a highly-ordered, unique reference work on the structure, function and pathophysiology of the pulmonary circulation. New for the third edition: Thoroughly revised with comprehensive coverage from diagnosis and clinical evaluation of pulmonary hypertension, to imaging techniques, disorders and treatment A new truly global team of expert editors, authors and key opinion leaders provide a wealth of detail on the latest developments and issues New chapters, such as: paediatrics, critical care, special environments including high altitude and underwater More quality chapters, authors, illustrations with thorough and thoughtful referencing make this book a contemporary essential reference text Pulmonary Circulation remains an essential resource for pulmonary hypertension specialists and should prove invaluable in all respiratory, cardiac and intensive care units.
Deals with a very important business in global communication of news -- the news agencies. The first news agencies started their business when the fastest technology was a combination of telegraph and carrier pigeon. They have survived several technological developments since then and have used these technologies for further diversification of services and revenues. The Internet, some thought, will make the news agencies extinct like dinosaurs. But, well run news agencies found a new opportunity in this threat. Though there have been some corporate biographies of news agencies, there has not been any comprehensive analytical work in the past 25 years on this business. This book is an attempt to fill this void in the global literature on journalism, media studies, international communication and business management studies. Besides, the students of these academic disciplines, diplomats, policymakers, and all types of communication professionals will find this book useful. It will also be a good read for lay persons who unconsciously consume the products of news agencies through all types of media -- from newspapers to mobile phones.
This volume explores the challenges of educating professionals to succeed in a complex, uncertain and global business world. The book contains intellectual concepts and practical advice from leaders in innovative education around the globe. It will help educators and the educational enterprise become more innovative, efficient, and effective in addressing the teaching/learning challenges associated with helping students prepare to face their own challenges.
Lewis E. Lehrman’s biography recounts a purposeful life of accomplishments. He was instrumental early on in building up the family business, Rite Aid. Later he formed a successful investment business, joined Morgan Stanley, and founded a hedge fund. To further his passion for study, he founded the Lehrman Institute and, with Richard Gilder, the Gilder Lehrman Institute of American History, receiving the National Humanities Medal in 2005 for their groundbreaking work in history. Lehrman endowed the Lincoln Prize, partnered with Monticello, and created the Gilder Lehrman Center for the Study of Slavery, Resistance, and Abolition at Yale. His significant collection of historical documents and...
This heavily revised second edition of this critical book details the structure, function and imaging of the normal right heart both at rest and under the stresses of high altitude and exercise. Extensively revised chapters cover the pathophysiology and pathobiology of right heart dysfunction, both in experimental models and human disease, including congenital heart disease and pulmonary hypertension. The Right Heart provides a concise up-to-date guide on the latest advances in our understanding of role of the right heart in the cardiopulmonary circuit and is an indispensable up-to-date resource for clinicians interested in this topic.
Critical Reflections draws together the multi-disciplinary research of scholars working in/on cities across Southeast Asia. The fourteen essays collected in the volume are organised into three thematic sections: (re)conceptualisation, competition and intervention. Collectively, these reflections contribute to and interrogate the expanding urban and regional studies literature. The volume constitutes a critical corrective to the existing literature which all-too-often seeks to diagnose contemporary urban trends everywhere from a small number of, mostly Western, "paradigmatic cases". Yet, while acknowledging the increasing interconnectedness and shared global orientation of most cities in Southeast Asia, the volume is wary of positing an equally generalising regional model. Individually, these essays attend to the diversity of contemporary urban experiences in Southeast Asia.
Drawing together recent changes in the debates with the history of the subject, The Process of Economic Development is a textbook with a story to tell. A discussion of recent events is integral to the book, with discussions ranging from * the environment * the debt crisis * export led industrialization * import substitution industrialization * growth theory and technological capability The book has an accessible style and format. Plentiful diagrams, boxed summaries, and end of chapter questions help the reader to grasp many-faceted topics. Coverage includes Latin America, Africa and Asia giving students a uniquely balanced world picture.