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Gliomas microenvironment: New drug entities, mechanisms of action, molecular biomarkers and drug delivery strategies
Gliomas are neoplasms originating in glial cells, the most malignant and frequent primary tumors of the Central Nervous System (CNS), representing approximately 40-50% of all intracranial tumors. Following the World Health Organization (WHO) guidelines, gliomas are classified into grades I-IV, regarding their malignancy degree. The latest report from WHO on CNS tumors considers that glioblastoma (GB), a grade IV adult-type diffuse glioma comprising isocitrate dehydrogenase (IDH)-wildtype tumors. Despite all efforts to improve patient survival and quality of life, the median survival remains lower due to the lack of effective diagnostic tools, poor prognosis, and limited therapeutic options. ...
New Insights into Glioblastoma
New Insights into Glioblastoma: Diagnosis, Therapeutics and Theranostics provides a compendium of recent diagnostic and therapeutic advances in GBM, encompassing a pipeline of compounds and (bio) nanotechnology strategies that have stood out with potential increased antitumoral activity and capability to cross the blood-brain barrier. Issues and challenges related to their translation into the clinical practice and their contribution to the increase in survival rates and well-being of patients are addressed. This is a valuable resource for graduate students, oncologists, cancer researchers and members of the biomedical field who need to learn more on recent developments on the management of ...
Design and Development of New Nanocarriers
Design and Development of New Nanocarriers focuses on the design and development of new nanocarriers used in pharmaceutical applications that have emerged in recent years. In particular, the pharmaceutical uses of microfluidic techniques, supramolecular design of nanocapsules, smart hydrogels, polymeric micelles, exosomes and metal nanoparticles are discussed in detail. Written by a diverse group of international researchers, this book is a valuable reference resource for those working in both biomaterials science and the pharmaceutical industry. - Shows how nanomanufacturing techniques can help to create more effective, cheaper pharmaceutical products - Explores how nanofabrication techniques developed in the lab have been translated to commercial applications in recent years - Explains safety and regulatory aspects of the use of nanomanufacturing processes in the pharmaceutical industry
Plug-Ins
This book’s central argument is that plug-ins, situated design outcomes that aim to enrich the complex system of the city and expand its potentialities, are a solid yet supple conceptual framework for rethinking how design can be a key agent in city making. This book showcases some of the projects developed by Elisava’s Design for City Making Research Lab, a research institute that investigates the role of design in the material and social construction of our habitats, focusing on spatiality, temporality, interactions, meaning, citizen engagement and social impact. Projects by students, professors and researchers, in collaboration with multiple partners including the public administratio...
Citizen Emperor
In the history of post-colonial Latin America no person has held power so firmly and for so long as did Pedro II as emperor of Brazil. This is the first full-length biography in 60 years, and the first in any language to make close use of Pedro II's diaries and family papers.
Advances in Pharmaceutical Biotechnology
This book explains both the basic science and the applications of biotechnology-derived pharmaceuticals, with special emphasis on their clinical uses. The foundations of pharmaceutical biotechnology lie mainly in the capability of plants, microorganism, and animals to produce low and high molecular weight compounds useful as therapeutics. Pharmaceutical biotechnology has flourished since the advent of recombinant DNA technology and metabolic engineering, supported by the well-developed bioprocess technology. A large number of monoclonal antibodies and therapeutic proteins have been approved, delivering meaningful contributions to patients’ lives, and the techniques of biotechnology are als...
Second Temple Pseudepigraphy
At this point of the scholarly debate on the nature of Second Temple pseudepigraphy, one may ask why another look at the problem is needed. This book is not the definitive answer to that problem but it proposes different paths - or better still, a two-fold path: on one hand to understand Second Temple pseudepigraphy as a mystical experience and on the other, for lack of a suitable ancient example, to compare it to modern-day automatic writing.
