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Immunological Challenges Around Pregnancy Complications Associated With Failures of Maternal Tolerance to the Fetus
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Current Challenges in Complement Diagnostics
The complement system is an important innate immune surveillance network that has a key role in protecting our bodies against pathogens and other threats. It is a highly complex system consisting of approximately 50 soluble and cell surface-bound proteins that interact to eliminate danger signals. These signals include factors such as invading microorganisms, necrotic cells, and immune complexes. Furthermore, complement can link innate and adaptive immune responses by regulating T cell and B cell responses. The complement system is tightly regulated to avoid uncontrolled activation. Dysregulation of the complement system has been linked to numerous diseases, both rare and common. Uncontrolle...
Effects of Endogenous and Exogenous Factors on Reproductive System Development
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Adverse pregnancy outcomes in systemic lupus erythematosus
Abstract: Systemic lupus erythematosus (SLE) is a chronic autoimmune disease of unknown etiology, characterized by a wide range of manifestations that can vary from mild to severe or even life-threatening multiple organ system involvement. SLE predominantly affects women and has a peak incidence during women’s reproductive age. Given the complexity of SLE, managing pregnancy in these women is particularly challenging, as the disease itself can impact pregnancy outcomes, and conversely, pregnancy can exacerbate SLE symptoms. This thesis aims to explore pregnancy complications among women with SLE and to assess the feasibility of utilizing specific biomarkers for evaluating the risk of adver...
Principles of Oocyte and Embryo Donation
The versatility of oocyte and embryo donation has proven to be extremely valuable to both patients and doctors engaged in reproductive medicine. Originally thought to be applicable only to a rather small subset of infertile women, today busy practices commonly recommend the procedure and it is estimated that nearly all of the 400 or more IVF programs in the United States provide these services. Oocyte and embryo donation has established itself as a mainstay procedure within assisted reproductive care, and the breadth, depth and complexity of practice is deserving of focused attention. Much has changed within the field of oocyte and embryo donation since the publication of the first edition o...
War and Cultural Heritage
This book explores the relationship between cultural heritage and conflict through the use of new empirical evidence and critical theory and by focusing on postconflict scenarios. It includes in-depth case studies and analytic reflections on the common threads and wider implications of the agency of cultural heritage in postconflict scenarios.
Dynastic Colonialism
Dynastic Colonialism analyses how women and men employed objects in particular places across the world during the early modern period in order to achieve the remarkable expansion of the House of Orange-Nassau. Susan Broomhall and Jacqueline Van Gent explore how the House emerged as a leading force during a period in which the Dutch accrued one of the greatest seaborne empires. Using the concept of dynastic colonialism, they explore strategic behaviours undertaken on behalf of the House of Orange-Nassau, through material culture in a variety of sites of interpretation from palaces and gardens to prints and teapots, in Europe and beyond. Using over 140 carefully selected images, the authors co...
