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Structural and Functional Organization of the Synapse
This new Springer volume, which comes complete with a free DVD, is a comprehensive and detailed overview of the synapse with emphasis on the glutamatergic synapse. Most chapters relate the synapse’s functional aspects to its molecular mechanisms. This approach shows which mechanisms are characterized on both the functional and structural level and can thus be considered firmly established. It’s an important text for neuroscientists and disease-oriented clinicians in neurology.
The Future of Drug Discovery
The Future of Drug Discovery: Who decides which diseases to treat? provides a timely and detailed look at the efforts of the pharmaceutical industry and how they relate, or should relate, to societal needs. The authors posit that as a result of increasing risk aversion and accelerated savings in research and development, the industry is not developing drugs for increasingly prevalent diseases, such as Alzheimer's disease, untreatable pain, antibiotics and more. This book carefully exposes the gap between the medicines and therapies we need and the current business path. By analyzing the situation and discussing prospects for the next decade, the The Future of Drug Discovery is a timely book ...
The Spike
The story of a neural impulse and what it reveals about how our brains work We see the last cookie in the box and think, can I take that? We reach a hand out. In the 2.1 seconds that this impulse travels through our brain, billions of neurons communicate with one another, sending blips of voltage through our sensory and motor regions. Neuroscientists call these blips “spikes.” Spikes enable us to do everything: talk, eat, run, see, plan, and decide. In The Spike, Mark Humphries takes readers on the epic journey of a spike through a single, brief reaction. In vivid language, Humphries tells the story of what happens in our brain, what we know about spikes, and what we still have left to u...
Protein Trafficking in Neurons
The efficient delivery of cellular constituents to their proper location is of fundamental importance for all cells and is of particular interest to neuroscientists, because of the unique functions and complex architecture of neurons. Protein Trafficking in Neurons examines mechanisms of protein trafficking and the role of trafficking in neuronal functioning from development to plasticity to disease. The book is divided into seven sections that review mechanisms of protein transport, the role of protein trafficking in synapse formation, exo- and endocytosis, transport of receptors, trafficking of ion channels and transporters, comparison of trafficking mechanisms in neuronal vs. non-neuronal...
Research Funding in Neuroscience
The book is a history of the McKnight Endowment Fund for Neuroscience and an assessment of its effectiveness in advancing neuroscience. The book discusses the Fund's early and steady commitment to basic science as well as it's tradition of leveraging relatively modest dollars to make a big difference in careers and the field overall. The fund exists strictly to give awards and create a community of peers through an annual conference dedicated to research. In near unison, scientists who have received awards say they were able to test a risky idea, get their career off the ground, or make a significant change in their career because of McKnight's flexible dollars. The book consists of three parts: (1) origins--including both the funder and the scientists who shaped the program; (2) a review of the science to show how McKnight awardees have advanced the field; and (3) 10 keys to success. We also have an interview with Julius Axelrod (one of the early advisors, done shortly before his death in 2004) and stories of how awardees used their McKnight grants, plus other information.
The Boardgamer Volume 1
The Boardgamer magazine was a quarterly magazine devoted primarily, but not exclusively, to the coverage of Avalon Hill / Victory Games titles and to other aspects of the boardgaming hobby. Initially, The Boardgamer’s publication ran concurrently with Avalon Hill’s house magazine, The General, but instead of focusing on new releases, it devoted coverage to those classic, Avalon Hill games which no longer graced the pages of The General. Following the cessation of The General in June 1998, The Boardgamer was the primary periodical dedicated to the titles from AH/VG, until its final issue in 2004. In these issues, the articles include: De-Randomizing The Circus - CIRCUS MAXIMUS Setup Revis...
Killer Dad
A devoutly religious husband and father is revealed as a murderous sex addict in this true crime case featured on 48 Hours Mystery. In November of 2001, Colorado family man Michael Blagg called 911 in distress over his missing wife and six-year-old daughter, exclaiming “Oh my god . . . there’s blood all over!” But frantic search parties and Michael's anguished pleas on national television came up empty. Then the investigation stumbled across Blagg’s dark side. A devout born-again Christian, Blagg was addicted to Internet porn. He also reportedly abused his wife and indulged in the services of hired escorts. Then in June 2002, nearly a year after her disappearance, his wife's mummified remains were found in a local landfill. And Michael quickly left town. Extradited from Georgia, Blagg was charged with first-degree murder. But the explosive trial was rocked by even more bizarre revelations, stunning twists, and an unspeakable mystery that haunted the country: What made Blagg do it? And, even more disturbing, whatever happened to little Abby? Includes sixteen pages of shocking photos
